Kawasaki disease-a new manifestation of COVID-19 in children
JIAO Fu-Yong
Center of Diagnosis and Treatment of Kawasaki Disease in Shaanxi Province/Children's Hospital, Shaanxi Provincial People's Hospital, Xi'an 710068, China
Abstract Since the outbreak of coronavirus disease 2019 (COVID-19) in Europe and America, the incidence of Kawasaki disease has significantly increased, which has aroused concern among pediatricians and parents. COVID-19 can cause inflammation reactions of multiple organs, which is similar to the systemic vasculitis of Kawasaki disease, and even COVID-19 can cause skin rash on the extremities of the limbs, which is also similar to Kawasaki disease. The cause of Kawasaki disease is currently unclear, and it cannot be ruled out that COVID-19 is associated with an increased incidence of Kawasaki disease. Therefore, during the epidemic of COVID-19, if children have symptoms similar to Kawasaki disease, intravenous immunoglobulin is recommended as early as possible to reduce the incidence of coronary artery lesions.
Jiao F, Yan X, Wu X. The Xi'an experience of Kawasaki disease-lessons learnt over 5 years[J]. Indian J Pediatr, 2016, 83(10):1195-1196.
[3]
Elakabawi K, Lin J, Jiao F, et al. Kawasaki disease:global burden and genetic background[J]. Cardiol Res, 2020, 11(1):9-14.
[4]
McCrindle BW, Rowley AH, Newburger JW, et al. Diagnosis, treatment, and long-term management of Kawasaki disease:a scientific statement for health professionals from the American Heart Association[J]. Circulation, 2017, 135(17):e927-e999.
[5]
Kuo HC, Li SC, Guo MM, et al. Genome-wide association study identifies novel susceptibility genes associated with coronary artery aneurysm formation in Kawasaki disease[J]. PLoS One, 2016, 11(5):e0154943.
[6]
Guo MM, Tseng WN, Ko CH, et al. Th17-and Treg-related cytokine and mRNA expression are associated with acute and resolving Kawasaki disease[J]. Allergy, 2015, 70(3):310-318.
[7]
Shi Z, Hu Z. A review of studies on animal reservoirs of the SARS coronavirus[J]. Virus Res, 2008, 133(1):74-87.
[8]
Woodyatt A, Howard J. Coronavirus could be tied to a rare but serious illness in children, UK doctors say[EB/OL]. (2020-04-27)[2020-05-16]. https:/edition.cnn.com/2020/04/27/health/children-covid-19-illness-intl-scli-gbr.
[9]
Odom John AR. New York announces deaths of children from illness linked to COVID-19[EB/OL]. (2020-05-11)[2020-05-16]. https://www.healio.com/news/pediatrics/20200511/new-york-announces-deaths-of-children-from-illness-linked-to-covid19.
[10]
Riphagen S, Gomez X, Gonzalez-Martinez C, et al. Hyperinflammatory shock in children during COVID-19 pandemic[J]. Lancet, 2020, 395(10237):1607-1608.
