单倍体造血干细胞移植治疗儿童重型再生障碍性贫血的研究进展

doi:10.7499/j.issn.1008-8830.2105073

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Abstract Haploidentical hematopoietic stem cell transplantation is a recommended alternative therapy for children with severe aplastic anemia who lack a human leukocyte antigen (HLA)-identical sibling donor and do not respond well to immunosuppressive therapy; however, due to non-identical HLA, the patients may have donor-specific anti-HLA antibody, which may lead to a relatively high incidence rate of poor graft function. Compared with HLA-identical transplantation, conditioning regimen for haploidentical transplantation still needs to be explored. This article reviews the detection and treatment of donor-specific anti-HLA antibody, the selection of conditioning regimen, and the mechanism and treatment of poor graft function in haploidentical hematopoietic stem cell transplantation.

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	GAO Yang-Yang
	CHEN Xiao-Juan
	LUO Rong-Mu

Key words： Severe aplastic anemia Haploidentical hematopoietic stem cell transplantation Donor-specific anti-HLA antibody Conditioning regimen Poor graft function Child

Received: 18 May 2021

Corresponding Authors: Chen X-J, Email: chenxiaojuan@ihcams.ac.cn E-mail: chenxiaojuan@ihcams.ac.cn

Cite this article:

GAO Yang-Yang,CHEN Xiao-Juan,LUO Rong-Mu. Research advances on haploidentical hematopoietic stem cell transplantation in the treatment of severe aplastic anemia in children[J]. CJCP, 2021, 23(8): 854-859.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2105073 OR http://www.zgddek.com/EN/Y2021/V23/I8/854

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