Research advances on haploidentical hematopoietic stem cell transplantation in the treatment of severe aplastic anemia in children
GAO Yang-Yang, CHEN Xiao-Juan, LUO Rong-Mu
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China
Abstract Haploidentical hematopoietic stem cell transplantation is a recommended alternative therapy for children with severe aplastic anemia who lack a human leukocyte antigen (HLA)-identical sibling donor and do not respond well to immunosuppressive therapy; however, due to non-identical HLA, the patients may have donor-specific anti-HLA antibody, which may lead to a relatively high incidence rate of poor graft function. Compared with HLA-identical transplantation, conditioning regimen for haploidentical transplantation still needs to be explored. This article reviews the detection and treatment of donor-specific anti-HLA antibody, the selection of conditioning regimen, and the mechanism and treatment of poor graft function in haploidentical hematopoietic stem cell transplantation.
GAO Yang-Yang,CHEN Xiao-Juan,LUO Rong-Mu. Research advances on haploidentical hematopoietic stem cell transplantation in the treatment of severe aplastic anemia in children[J]. CJCP, 2021, 23(8): 854-859.
GAO Yang-Yang,CHEN Xiao-Juan,LUO Rong-Mu. Research advances on haploidentical hematopoietic stem cell transplantation in the treatment of severe aplastic anemia in children[J]. CJCP, 2021, 23(8): 854-859.
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