Abstract Objective To systematically assess the risk factors for the colonization or infection of carbapenem-resistant Enterobacteriaceae in children. Methods PubMed, Web of Science, China National Knowledge Infrastructure Database, Wanfang Data, China Biology Medicine disc were searched to obtain the articles on risk factors for the colonization or infection of carbapenem-resistant Enterobacteriaceae in children published up to May 31, 2021. RevMan 5.3 software was used to perform the Meta analysis. Results A total of 13 articles were included, with 1 501 samples in total. The Meta analysis showed that indwelling gastric tube (OR=4.91), tracheal intubation (OR=5.03), central venous catheterization (OR=3.75), indwelling urinary catheterization (OR=4.11), mechanical ventilation (OR=3.09), history of hospitalization in the intensive care unit (OR=2.39), history of surgical operation (OR=3.22), previous use of third-generation cephalosporins (OR=2.62), previous use of carbapenem antibiotics (OR=3.82), previous use of glycopeptide antibiotics (OR=3.48), previous use of β-lactamase inhibitors (OR=2.87), previous use of antifungal drugs (OR=2.48), previous use of aminoglycoside antibiotics (OR=2.54), and Apgar score ≤7 at 1 minute after birth (OR=2.10) were risk factors for the colonization or infection of carbapenem-resistant Enterobacteriaceae in children (P<0.05). Conclusions Invasive operations, history of hospitalization in the intensive care unit, previous use of antibiotics such as carbapenem antibiotics, and Apgar score ≤7 at 1 minute after birth are risk factors for the colonization or infection of carbapenem-resistant Enterobacteriaceae in children.
LIN Bi-Yu,LIU Jing-Ting,JIN Feng-Ling. Risk factors for the colonization or infection of carbapenem-resistant Enterobacteriaceae in children: a Meta analysis[J]. CJCP, 2022, 24(1): 96-101.
LIN Bi-Yu,LIU Jing-Ting,JIN Feng-Ling. Risk factors for the colonization or infection of carbapenem-resistant Enterobacteriaceae in children: a Meta analysis[J]. CJCP, 2022, 24(1): 96-101.
Zhang YW, Wang Q, Yin YY, et al. Epidemiology of carbapenem-resistant Enterobacteriaceae infections: report from the China CRE Network[J]. Antimicrob Agents Chemother, 2018, 62(2): e01882-17. PMID: 29203488. PMCID: PMC5786810. DOI: 10.1128/AAC.01882-17.
Logan LK. Carbapenem-resistant Enterobacteriaceae: an emerging problem in children[J]. Clin Infect Dis, 2012, 55(6): 852-859. PMID: 22700827. DOI: 10.1093/cid/cis543.
Magiorakos AP, Burns K, Rodríguez Ba?o J, et al. Infection prevention and control measures and tools for the prevention of entry of carbapenem-resistant Enterobacteriaceae into healthcare settings: guidance from the European Centre for Disease Prevention and Control[J]. Antimicrob Resist Infect Control, 2017, 6: 113. PMID: 29163939. PMCID: PMC5686856. DOI: 10.1186/s13756-017-0259-z.
Senchyna F, Gaur RL, Sandlund J, et al. Diversity of resistance mechanisms in carbapenem-resistant Enterobacteriaceae at a health care system in Northern California, from 2013 to 2016[J]. Diagn Microbiol Infect Dis, 2019, 93(3): 250-257. PMID: 30482638. PMCID: PMC7155946. DOI: 10.1016/j.diagmicrobio.2018.10.004.
7 Ottawa Hospital Research Institute. Newcastle-Ottawa quality assessment scale case control studies[EB/OL]. [2021-08-20].
Alzomor OA, Alfawaz TS, Abu-Shaheen A, et al. A matched case-control study to assess the carbapenem-resistant Enterobacteriaceae infections among hospitalized children at King Fahad Medical City, Riyadh, Saudi Arabia[J]. Saudi Med J, 2019, 40(11): 1105-1110. PMID: 31707406. PMCID: PMC6901765. DOI: 10.15537/smj.2019.11.24586.
Chiotos K, Tamma PD, Flett KB, et al. Multicenter study of the risk factors for colonization or infection with carbapenem-resistant Enterobacteriaceae in children[J]. Antimicrob Agents Chemother, 2017, 61(12): e01440-17. PMID: 28971864. PMCID: PMC5700345. DOI: 10.1128/AAC.01440-17.
Logan LK, Nguyen DC, Scaggs Huang FA, et al. A multi-centered case-case-control study of factors associated with Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae infections in children and young adults[J]. Pediatr Infect Dis J, 2019, 38(5): 490-495. PMID: 30169484. PMCID: PMC6395555. DOI: 10.1097/INF.0000000000002176.
Singh NP, Choudhury DD, Gupta K, et al. Predictors for gut colonization of carbapenem-resistant Enterobacteriaceae in neonates in a neonatal intensive care unit[J]. Am J Infect Control, 2018, 46(6): e31-e35. PMID: 29803234. DOI: 10.1016/j.ajic.2018.01.007.
Zhang Y, Guo LY, Song WQ, et al. Risk factors for carbapenem-resistant K. pneumoniae bloodstream infection and predictors of mortality in Chinese paediatric patients[J]. BMC Infect Dis, 2018, 18(1): 248. PMID: 29855274. PMCID: PMC5984460. DOI: 10.1186/s12879-018-3160-3.
The American College of Obstetricians and Gynecologists Women's Health Care Physicians. Committee opinion No. 644: the Apgar score[J]. Obstet Gynecol, 2015, 126(4): e52-e55. PMID: 26393460. DOI: 10.1097/AOG.0000000000001108.
Rozaidi SW, Sukro J, Dan A. The incidence of nosocomial infection in the intensive care unit, Hospital Universiti Kebangsaan Malaysia: ICU-acquired nosocomial infection surveillance program 1998-1999[J]. Med J Malaysia, 2001, 56(2): 207-222. PMID: 11771082.
WANG Hui-Min, LIU Chuan-He, LIU Chang-Shan, WANG Ying, HAN Zhi-Ying, SUN Xin, CHEN Xing, AN Shu-Hua, DUOLIKUN Muzhapaer, LU Ai-Ping, WANG Min, CHENG Yan, YIN Xiao-Mei, LIU Han-Min, WANG Hong, HUA Shan, DONG Li, HUANG Ying, JIANG Yi, XIONG Jian-Xin, DING Sheng-Gang, ZHAO Shun-Ying, WANG Jin-Rong, HUANG Gui-Min, MU Jing-Hui, CHEN Yu-Zhi. Efficacy of Huaiqihuang granules as adjuvant therapy for bronchial asthma in children: a real-world study[J]. CJCP, 2021, 23(9): 877-881.