住院极早产儿宫外生长迟缓及相关因素的多中心前瞻性研究

doi:10.7499/j.issn.1008-8830.2111143

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Abstract Objective To investigate the incidence of extrauterine growth retardation (EUGR) and its risk factors in very preterm infants (VPIs) during hospitalization in China. Methods A prospective multicenter study was performed on the medical data of 2 514 VPIs who were hospitalized in the department of neonatology in 28 hospitals from 7 areas of China between September 2019 and December 2020. According to the presence or absence of EUGR based on the evaluation of body weight at the corrected gestational age of 36 weeks or at discharge, the VPIs were classified to two groups: EUGR group (n=1 189) and non-EUGR (n=1 325). The clinical features were compared between the two groups, and the incidence of EUGR and risk factors for EUGR were examined. Results The incidence of EUGR was 47.30% (1 189/2 514) evaluated by weight. The multivariate logistic regression analysis showed that higher weight growth velocity after regaining birth weight and higher cumulative calorie intake during the first week of hospitalization were protective factors against EUGR (P<0.05), while small-for-gestational-age birth, prolonged time to the initiation of total enteral feeding, prolonged cumulative fasting time, lower breast milk intake before starting human milk fortifiers, prolonged time to the initiation of full fortified feeding, and moderate-to-severe bronchopulmonary dysplasia were risk factors for EUGR (P<0.05). Conclusions It is crucial to reduce the incidence of EUGR by achieving total enteral feeding as early as possible, strengthening breastfeeding, increasing calorie intake in the first week after birth, improving the velocity of weight gain, and preventing moderate-severe bronchopulmonary dysplasia in VPIs.

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	SHEN Wei
	ZHENG Zhi
	LIN Xin-Zhu
	WU Fan
	TIAN Qian-Xin
	CUI Qi-Liang
	YUAN Yuan
	REN Ling
	MAO Jian
	SHI Bi-Zhen
	WANG Yu-Mei
	LIU Ling
	ZHANG Jing-Hui
	CHANG Yan-Mei
	TONG Xiao-Mei
	ZHU Yan
	ZHANG Rong
	YE Xiu-Zhen
	ZOU Jing-Jing
	LI Huai-Yu
	ZHAO Bao-Yin
	QIU Yin-Ping
	LIU Shu-Hua
	MA Li
	XU Ying
	CHENG Rui
	ZHOU Wen-Li
	WU Hui
	LIU Zhi-Yong
	CHEN Dong-Mei
	GAO Jin-Zhi
	LIU Jing
	CHEN Ling
	LI Cong
	YANG Chun-Yan
	XU Ping
	ZHANG Ya-Yu
	HU Si-Le
	MEI Hua
	YANG Zu-Ming
	FENG Zong-Tai
	WANG San-Nan
	MENG Er-Yan
	SHANG Li-Hong
	XU Fa-Lin
	OU Shao-Ping
	JU Rong

Key words： Extrauterine growth retardation Nutrition Risk factor Very preterm infant

Received: 24 November 2021

Cite this article:

SHEN Wei,ZHENG Zhi,LIN Xin-Zhu et al. Incidence of extrauterine growth retardation and its risk factors in very preterm infants during hospitalization: a multicenter prospective study[J]. CJCP, 2022, 24(2): 132-140.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2111143 OR http://www.zgddek.com/EN/Y2022/V24/I2/132

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