Incidence of extrauterine growth retardation and its risk factors in very preterm infants during hospitalization: a multicenter prospective study

SHEN Wei; ZHENG Zhi; LIN Xin-Zhu; WU Fan; TIAN Qian-Xin; CUI Qi-Liang; YUAN Yuan; REN Ling; MAO Jian; SHI Bi-Zhen; WANG Yu-Mei; LIU Ling; ZHANG Jing-Hui; CHANG Yan-Mei; TONG Xiao-Mei; ZHU Yan; ZHANG Rong; YE Xiu-Zhen; ZOU Jing-Jing; LI Huai-Yu; ZHAO Bao-Yin; QIU Yin-Ping; LIU Shu-Hua; MA Li; XU Ying; CHENG Rui; ZHOU Wen-Li; WU Hui; LIU Zhi-Yong; CHEN Dong-Mei; GAO Jin-Zhi; LIU Jing; CHEN Ling; LI Cong; YANG Chun-Yan; XU Ping; ZHANG Ya-Yu; HU Si-Le; MEI Hua; YANG Zu-Ming; FENG Zong-Tai; WANG San-Nan; MENG Er-Yan; SHANG Li-Hong; XU Fa-Lin; OU Shao-Ping; JU Rong

doi:10.7499/j.issn.1008-8830.2111143

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Chinese Journal of Contemporary Pediatrics ›› 2022, Vol. 24 ›› Issue (2) : 132-140. DOI: 10.7499/j.issn.1008-8830.2111143

CLINICAL RESEARCH

Incidence of extrauterine growth retardation and its risk factors in very preterm infants during hospitalization: a multicenter prospective study

SHEN Wei, ZHENG Zhi, LIN Xin-Zhu, WU Fan, TIAN Qian-Xin, CUI Qi-Liang, YUAN Yuan, REN Ling, MAO Jian, SHI Bi-Zhen, WANG Yu-Mei, LIU Ling, ZHANG Jing-Hui, CHANG Yan-Mei, TONG Xiao-Mei, ZHU Yan, ZHANG Rong, YE Xiu-Zhen, ZOU Jing-Jing, LI Huai-Yu, ZHAO Bao-Yin, QIU Yin-Ping, LIU Shu-Hua, MA Li, XU Ying, CHENG Rui, ZHOU Wen-Li, WU Hui, LIU Zhi-Yong, CHEN Dong-Mei, GAO Jin-Zhi, LIU Jing, CHEN Ling, LI Cong, YANG Chun-Yan, XU Ping, ZHANG Ya-Yu, HU Si-Le, MEI Hua, YANG Zu-Ming, FENG Zong-Tai, WANG San-Nan, MENG Er-Yan, SHANG Li-Hong, XU Fa-Lin, OU Shao-Ping, JU Rong

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Abstract

Objective To investigate the incidence of extrauterine growth retardation (EUGR) and its risk factors in very preterm infants (VPIs) during hospitalization in China. Methods A prospective multicenter study was performed on the medical data of 2 514 VPIs who were hospitalized in the department of neonatology in 28 hospitals from 7 areas of China between September 2019 and December 2020. According to the presence or absence of EUGR based on the evaluation of body weight at the corrected gestational age of 36 weeks or at discharge, the VPIs were classified to two groups: EUGR group (n=1 189) and non-EUGR (n=1 325). The clinical features were compared between the two groups, and the incidence of EUGR and risk factors for EUGR were examined. Results The incidence of EUGR was 47.30% (1 189/2 514) evaluated by weight. The multivariate logistic regression analysis showed that higher weight growth velocity after regaining birth weight and higher cumulative calorie intake during the first week of hospitalization were protective factors against EUGR (P<0.05), while small-for-gestational-age birth, prolonged time to the initiation of total enteral feeding, prolonged cumulative fasting time, lower breast milk intake before starting human milk fortifiers, prolonged time to the initiation of full fortified feeding, and moderate-to-severe bronchopulmonary dysplasia were risk factors for EUGR (P<0.05). Conclusions It is crucial to reduce the incidence of EUGR by achieving total enteral feeding as early as possible, strengthening breastfeeding, increasing calorie intake in the first week after birth, improving the velocity of weight gain, and preventing moderate-severe bronchopulmonary dysplasia in VPIs.

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Extrauterine growth retardation / Nutrition / Risk factor / Very preterm infant

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SHEN Wei, ZHENG Zhi, LIN Xin-Zhu, WU Fan, TIAN Qian-Xin, CUI Qi-Liang, YUAN Yuan, REN Ling, MAO Jian, SHI Bi-Zhen, WANG Yu-Mei, LIU Ling, ZHANG Jing-Hui, CHANG Yan-Mei, TONG Xiao-Mei, ZHU Yan, ZHANG Rong, YE Xiu-Zhen, ZOU Jing-Jing, LI Huai-Yu, ZHAO Bao-Yin, QIU Yin-Ping, LIU Shu-Hua, MA Li, XU Ying, CHENG Rui, ZHOU Wen-Li, WU Hui, LIU Zhi-Yong, CHEN Dong-Mei, GAO Jin-Zhi, LIU Jing, CHEN Ling, LI Cong, YANG Chun-Yan, XU Ping, ZHANG Ya-Yu, HU Si-Le, MEI Hua, YANG Zu-Ming, FENG Zong-Tai, WANG San-Nan, MENG Er-Yan, SHANG Li-Hong, XU Fa-Lin, OU Shao-Ping, JU Rong. Incidence of extrauterine growth retardation and its risk factors in very preterm infants during hospitalization: a multicenter prospective study[J]. Chinese Journal of Contemporary Pediatrics. 2022, 24(2): 132-140 https://doi.org/10.7499/j.issn.1008-8830.2111143

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