不同维持剂量枸橼酸咖啡因对辅助通气早产儿的疗效评估：一项初步多中心研究

doi:10.7499/j.issn.1008-8830.2109144

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Abstract Objective To explore the optimal maintenance dose of caffeine citrate for preterm infants requiring assisted ventilation and caffeine citrate treatment. Methods A retrospective analysis was performed on the medical data of 566 preterm infants (gestational age ≤34 weeks) who were treated and required assisted ventilation and caffeine citrate treatment in the neonatal intensive care unit of 30 tertiary hospitals in Jiangsu Province of China between January 1 and December 31, 2019. The 405 preterm infants receiving high-dose (10 mg/kg per day) caffeine citrate after a loading dose of 20 mg/kg within 24 hours after birth were enrolled as the high-dose group. The 161 preterm infants receiving low-dose (5 mg/kg per day) caffeine citrate were enrolled as the low-dose group. Results Compared with the low-dose group, the high-dose group had significant reductions in the need for high-concentration oxygen during assisted ventilation (P=0.044), the duration of oxygen inhalation after weaning from noninvasive ventilation (P<0.01), total oxygen inhalation time during hospitalization (P<0.01), the proportion of preterm infants requiring noninvasive ventilation again (P<0.01), the rate of use of pulmonary surfactant and budesonide (P<0.05), and the incidence rates of apnea and bronchopulmonary dysplasia (P<0.01), but the high-dose group had a significantly increased incidence rate of feeding intolerance (P=0.032). There were no significant differences between the two groups in the body weight change, the incidence rates of retinopathy of prematurity, intraventricular hemorrhage or necrotizing enterocolitis, the mortality rate, and the duration of caffeine use (P>0.05). Conclusions This pilot multicenter study shows that the high maintenance dose (10 mg/kg per day) is generally beneficial to preterm infants in China and does not increase the incidence rate of common adverse reactions. For the risk of feeding intolerance, further research is needed to eliminate the interference of confounding factors as far as possible.

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	Articles by authors
	YANG Yang
	LU Ke-Yu
	CHENG Rui
	ZHOU Qin
	FANG Guang-Dong
	LI Hong
	SHAO Jie
	WANG Huai-Yan
	LI Zheng-Ying
	LIU Song-Lin
	LI Zhen-Guang
	CAI Jin-Lan
	XUE Mei
	CHEN Xiao-Qing
	PAN Zhao-Jun
	GAO Yan
	HUANG Li
	LI Hai-Ying
	SONG Lei
	WANG San-Nan
	SHU Gui-Hua
	WU Wei
	YU Meng-Zhu
	XU Zhun
	LI Hong-Xin
	XU Yan
	BAO Zhi-Dan
	WU Xin-Ping
	YE Li
	DONG Xue-Ping
	YIN Qi-Gai
	YIN Xiao-Ping
	ZHOU Jin-Jun

Key words： Caffeine Maintenance dose Respiration Preterm infant

Received: 26 September 2021

Cite this article:

YANG Yang,LU Ke-Yu,CHENG Rui et al. Clinical effect of different maintenance doses of caffeine citrate in the treatment of preterm infants requiring assisted ventilation: a pilot multicenter study[J]. CJCP, 2022, 24(3): 240-248.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2109144 OR http://www.zgddek.com/EN/Y2022/V24/I3/240

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