波生坦治疗新生儿持续性肺动脉高压有效性及安全性的Meta分析

doi:10.7499/j.issn.1008-8830.2109151

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Abstract Objective To systematically evaluate the efficacy and safety of bosentan in the treatment of persistent pulmonary hypertension of the newborn (PPHN). Methods Chinese Journal Full-text Database, Weipu Database, Wanfang Data, China Biology Medicine disc, PubMed, Web of Science, Embase, and Cochrane Library were searched for literature on bosentan in the treatment of PPHN published up to August 31, 2021. Results A total of 8 randomized controlled trials were included for Meta analysis. The results of the Meta analysis showed that compared with the control group, the bosentan treatment group had a significantly lower treatment failure rate (RR=0.23, P<0.001), a significantly greater reduction in pulmonary artery pressure [mean difference (MD)=-11.79, P<0.001)], significantly greater increases in oxygen partial pressure (MD=10.21, P=0.006) and blood oxygen saturation (MD=8.30, P<0.001), and a significantly shorter length of hospital stay (MD=-1.35, P<0.001). The descriptive analysis showed that the bosentan treatment group had a lower degree of tricuspid regurgitation than the control group after treatment. The main adverse reactions of bosentan treatment included abnormal liver function, anemia and edema. The results of subgroup analysis based on treatment regimen, research area, and drug dose were consistent with those before stratification. Conclusions Bosentan is effective in the treatment of PPHN. However, when using bosentan, attention should be paid to adverse reactions such as abnormal liver function.

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	LI Ling-Xue
	WEI Bing
	YANG Ming
	LI Mo
	JIA Jing-Jing

Key words： Persistent pulmonary hypertension Bosentan Meta analysis Neonate

Received: 27 September 2021

Cite this article:

LI Ling-Xue,WEI Bing,YANG Ming et al. Efficacy and safety of bosentan in the treatment of persistent pulmonary hypertension of the newborn: a Meta analysis[J]. CJCP, 2022, 24(3): 319-325.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2109151 OR http://www.zgddek.com/EN/Y2022/V24/I3/319

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