脐带挤压与延迟断脐对胎龄<34周早产儿早期预后影响的Meta分析

doi:10.7499/j.issn.1008-8830.2112088

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Abstract Objective To study the influence of umbilical cord milking versus delayed cord clamping on the early prognosis of preterm infants with a gestational age of <34 weeks. Methods PubMed, Web of Science, Embase, the Cochrane Library, CINAHL, China National Knowledge Infrastructure, Wanfang Data, Weipu Database, and SinoMed were searched for randomized controlled trials on umbilical cord milking versus delayed cord clamping in preterm infants with a gestational age of <34 weeks published up to November 2021. According to the inclusion and exclusion criteria, two researchers independently performed literature screening, quality evaluation, and data extraction. Review Manger 5.4 was used for Meta analysis. Results A total of 11 articles were included in the analysis, with 1 621 preterm infants in total, among whom there were 809 infants in the umbilical cord milking group and 812 in the delayed cord clamping group. The Meta analysis showed that compared with delayed cord clamping, umbilical cord milking increased the mean blood pressure after birth (weighted mean difference=3.61, 95%CI: 0.73-6.50, P=0.01), but it also increased the incidence rate of severe intraventricular hemorrhage (RR=1.83, 95%CI: 1.08-3.09, P=0.02). There were no significant differences between the two groups in hemoglobin, hematocrit, blood transfusion rate, proportion of infants undergoing phototherapy, bilirubin peak, and incidence rates of complications such as periventricular leukomalacia and necrotizing enterocolitis (P>0.05). Conclusions Compared with delayed cord clamping, umbilical cord milking may increase the risk of severe intraventricular hemorrhage in preterm infants with a gestational age of <34 weeks; however, more high-quality large-sample randomized controlled trials are needed for further confirmation. Citation:Chinese Journal of Contemporary Pediatrics, 2022, 24(5): 492-499

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	JIANG Wei-Wei
	FAN Xue-Mei
	ZHANG Jia-Hua
	FU Zi-Man
	PU Cong-Shan
	SHAN Chun-Jian

Key words： Umbilical cord milking Delayed cord clamping Intraventricular hemorrhage Placental transfusion Meta analysis Preterm infant

Received: 18 December 2021

Cite this article:

JIANG Wei-Wei,FAN Xue-Mei,ZHANG Jia-Hua et al. Influence of umbilical cord milking versus delayed cord clamping on the early prognosis of preterm infants with a gestational age of <34 weeks: a Meta analysis[J]. CJCP, 2022, 24(5): 492-499.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2112088 OR http://www.zgddek.com/EN/Y2022/V24/I5/492

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