Abstract Objective To examine the expression of serum thyroglobulin antibody (TGAb) and thyroid peroxidase antibody (TPOAb) in children with immune thrombocytopenia (ITP). Methods A total of 120 children with ITP who were admitted from October 2019 to October 2021 were enrolled as the ITP group. A total of 60 children without ITP were enrolled as the non-ITP group. According to the clinical classification of ITP, the children in the ITP group were further divided into a newly diagnosed ITP group, a persistent ITP group, and a chronic ITP group. The clinical data were compared between the ITP group and the non-ITP group and between the children with different clinical classifications of ITP. The expression levels of serum TGAb and TPOAb in children with ITP were measured and their association with the clinical classification of ITP was analyzed. Results Compared with the non-ITP group, the ITP group had significantly lower levels of CD3+, CD4+, and platelet count (PLT) and significantly higher levels of CD8+, TGAb, and TPOAb (P<0.05). The children with chronic ITP had significantly lower levels of CD3+, CD4+, and PLT and significantly higher levels of CD8+, TGAb, and TPOAb than those with newly diagnosed ITP or persistent ITP (P<0.05). The logistic regression analysis showed that CD3+, CD4+, CD8+, TGAb, and TPOAb were the influencing factors for chronic ITP (P<0.05). A decision curve was plotted, and the results showed that TGAb combined with TPOAb within the high-risk threshold range of 0.0-1.0 had a net benefit rate of >0 in evaluating the clinical classification of ITP in children. Conclusions TGAb and TPOAb are abnormally expressed in children with ITP and are associated with the clinical classification of ITP in children.
WANG Xue-Mei,NURIDDIN Hailigulli,LIU Yu et al. Expression of thyroglobulin antibody and thyroid peroxidase antibody in children with immune thrombocytopenia[J]. CJCP, 2022, 24(6): 687-692.
WANG Xue-Mei,NURIDDIN Hailigulli,LIU Yu et al. Expression of thyroglobulin antibody and thyroid peroxidase antibody in children with immune thrombocytopenia[J]. CJCP, 2022, 24(6): 687-692.
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Shaanxi Province Diagnosis and Treatment Center of Kawasaki Disease/Children's Hospital of Shaanxi Provincial
People's Hospital, Children's Hospital of Shanghai Jiao Tong University, Beijing Children's Hospital of Capital Medical
University, Shengjing Hospital of China Medical University, Affiliated Hospital of Yan'an University, Expert Committee
of Advanced Training for Pediatrician, China Maternal and Children's Health Association, General Pediatric Group of
Pediatrician Branch of Chinese Medical Doctor Association, Pediatric International Exchange and Cooperation Center,
Shanghai Cooperation Organization Hospital Cooperation Alliance, Editorial Board of Chinese Journal of
Contemporary Pediatrics. Pediatric expert consensus on the application of aspirin in Kawasaki disease[J]. CJCP, 2022, 24(6): 597-603.
