人类免疫缺陷病毒暴露未感染婴幼儿的神经心理发育状况

doi:10.7499/j.issn.1008-8830.2203037

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Abstract Objective To investigate the level of neuropsychological development in human immunodeficiency virus (HIV)-exposed uninfected (HEU) infants/young children and the influence of maternal HIV infection on the neuropsychological development of HEU infants/young children. Methods A total of 141 HEU infants/young children, aged 0-18 months and born to HIV-infected mothers, who were managed in four maternal and child health care hospitals in Yunnan Province of China from June 2019 to December 2020 and met the inclusion criteria were enrolled as the HEU group. A total of 141 HIV-unexposed uninfected (HUU) infants/young children who were born to healthy mothers and managed in the same hospitals, matched at a ratio of 1:1 based on sex, age, method of birth, birth weight, and gestational age, were enrolled as controls. Griffiths Development Scales-Chinese Edition was used to assess the development in the five domains of locomotion, personal-social, hearing and language, eye-hand co-ordination, and performance (visual perception and space integration ability). A questionnaire survey was performed to collect relevant information. The multivariate logistic regression analysis was used to assess the influence of maternal HIV infection on the neuropsychological development of HEU infants/young children. Results Compared with the HUU group, the HEU group had significantly higher detection rates of retardation in the domains of hearing and language and performance (P<0.05). The multivariate logistic regression analysis showed that maternal HIV infection increased the risk of retardation in the domains of hearing and language (OR=2.661, 95%CI: 1.171-6.047, P<0.05) and performance (OR=2.321, 95%CI: 1.156-4.658, P<0.05). Conclusions Maternal HIV infection can negatively affect the development of hearing and language and performance in HEU infants/young children, and further studies are needed to clarify related mechanisms. Citation:Chinese Journal of Contemporary Pediatrics, 2022, 24(9): 967-972

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	Articles by authors
	XIA Wei
	ZHENG Jia-Rui
	ZHENG Min
	LI Wen-Jia
	JIANG Cheng-Qin
	WU Ya-Ting
	HUANG Ze-Rong
	GUO Guang-Ping

Key words： Human immunodeficiency virus-exposure Neuropsychological development Child

Received: 06 March 2022

Cite this article:

XIA Wei,ZHENG Jia-Rui,ZHENG Min et al. Neuropsychological development of human immunodeficiency virus-exposed uninfected infants/young children[J]. CJCP, 2022, 24(9): 967-972.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2203037 OR http://www.zgddek.com/EN/Y2022/V24/I9/967

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