先天性纯红细胞再生障碍性贫血患儿肥胖发生情况及影响因素分析

doi:10.7499/j.issn.1008-8830.2206070

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Abstract Objective To investigate the distribution of body mass index (BMI) and risk factors for obesity in children with Diamond-Blackfan Anemia (DBA). Methods The children with DBA who attended National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, from January 2003 to December 2020 were enrolled as subjects. The related clinical data and treatment regimens were recorded. The height and weight data measured within 1 week before or after follow-up time points were collected to calculate BMI. The risk factors for obesity were determined by multivariate regression analysis in children with DBA. Results A total of 129 children with DBA were enrolled, among whom there were 80 boys (62.0%) and 49 girls (38.0%), with a median age of 49 months (range 3-189 months). The prevalence rate of obesity was 14.7% (19/129). The multivariate logistic regression analysis showed that the absence of ribosomal protein gene mutation was closely associated with obesity in children with DBA (adjusted OR=3.63, 95%CI: 1.16-11.38, adjusted P=0.027). In children with glucocorticoid-dependent DBA, obesity was not associated with age of initiation of glucocorticoid therapy, duration of glucocorticoid therapy, and maintenance dose of glucocorticoids (P>0.05). Conclusions There is a high prevalence rate of obesity in children with DBA, and the absence of ribosomal protein gene mutation is closely associated with obesity in children with DBA.

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	Articles by authors
	YI Mei-Hui
	WAN Yang
	CHENG Si-Qi
	GONG Xiao-Wen
	YIN Zi-Xi
	LI Jun
	GAO Yang-Yang
	WU Chao
	ZONG Su-Yu
	CHANG Li-Xian
	CHEN Yu-Mei
	ZHENG Rong-Xiu
	ZHU Xiao-Fan

Key words： Diamond-Blackfan anemia Body mass index Obesity Ribosomal protein gene Child

Received: 15 June 2022

Corresponding Authors: Zhu X-F, Email: xfzhu@ihcams.ac.cn E-mail: xfzhu@ihcams.ac.cn

Cite this article:

YI Mei-Hui,WAN Yang,CHENG Si-Qi et al. Prevalence and risk factors of obesity in children with Diamond-Blackfan anemia[J]. CJCP, 2022, 24(10): 1143-1148.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2206070 OR http://www.zgddek.com/EN/Y2022/V24/I10/1143

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