Abstract Objective To study the clinical features of children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant infection. Methods A retrospective analysis was performed on the medical data of 201 children with coronavirus disease 2019 (COVID-19) who were hospitalized and diagnosed with SARS-CoV-2 Omicron variant infection in Quanzhou First Hospital from March 14 to April 7, 2022. Among the 201 children, there were 34 children with asymptomatic infection and 167 with symptomatic infection. The two groups were compared in terms of clinical features, results of experimental examinations, and outcome. Results Of all the 201 children, 161 (80.1%) had a history of exposure to COVID-19 patients and 132 (65.7%) had a history of COVID-19 vaccination. Among the 167 children with symptomatic infections, 151 had mild COVID-19 and 16 had common COVID-19, with no severe infection or death. Among the 101 children who underwent chest CT examination, 16 had ground glass changes and 20 had nodular or linear opacities. The mean time to nucleic acid clearance was (14±4) days for the 201 children with Omicron variant infection, and the symptomatic infection group had a significantly longer time than the asymptomatic infection group [(15±4) days vs (11±4) days, P<0.05]. The group vaccinated with one or two doses of COVID-19 vaccine had a significantly higher positive rate of IgG than the group without vaccination (P<0.05). The proportions of children with increased blood lymphocyte count in the symptomatic infection group was significantly lower than that in the asymptomatic infection group (P<0.05). Compared with the asymptomatic infection group, the symptomatic infection group had significantly higher proportions of children with increased interleukin-6, increased fibrinogen, and increased D-dimer (P<0.05). Conclusions Most of the children with Omicron variant infection have clinical symptoms, which are generally mild. The children with symptomatic infection are often accompanied by decreased or normal blood lymphocyte count and increased levels of interleukin-6, fibrinogen, and D-dimer, with a relatively long time to nucleic acid clearance. Some of them had ground glass changes on chest CT.
ZHANG Yi-Fei,LIANG Shi-Shan,WU Pei-Lin et al. Clinical features of severe acute respiratory syndrome coronavirus 2 Omicron variant infection in children: an analysis of 201 cases[J]. CJCP, 2023, 25(1): 5-10.
ZHANG Yi-Fei,LIANG Shi-Shan,WU Pei-Lin et al. Clinical features of severe acute respiratory syndrome coronavirus 2 Omicron variant infection in children: an analysis of 201 cases[J]. CJCP, 2023, 25(1): 5-10.
Ai J, Zhang H, Zhang Y, et al. Omicron variant showed lower neutralizing sensitivity than other SARS-CoV-2 variants to immune sera elicited by vaccines after boost[J]. Emerg Microbes Infect, 2022, 11(1): 337-343. PMID: 34935594. PMCID: PMC8788341. DOI: 10.1080/22221751.2021.2022440.
Smith DJ, Hakim AJ, Leung GM, et al. COVID-19 mortality and vaccine coverage: Hong Kong Special Administrative Region, China, January 6, 2022 - March 21, 2022[J]. MMWR Morb Mortal Wkly Rep, 2022, 71(15): 545-548. PMID: 35421076. PMCID: PMC9020860. DOI: 10.15585/mmwr.mm7115e1.
Sughayer MA, Souan L, Abu Alhowr MM, et al. Comparison of the effectiveness and duration of anti-RBD SARS-CoV-2 IgG antibody response between different types of vaccines: Implications for vaccine strategies[J]. Vaccine, 2022, 40(20): 2841-2847. PMID: 35397946. PMCID: PMC8971065. DOI: 10.1016/j.vaccine.2022.03.069.
Boehme AK, Doyle K, Thakur KT, et al. Disorders of consciousness in hospitalized patients with COVID-19: the role of the systemic inflammatory response syndrome[J]. Neurocrit Care, 2022, 36(1): 89-96. PMID: 34184176. PMCID: PMC8238027. DOI: 10.1007/s12028-021-01256-7.
