嵌合抗原受体T细胞在儿童复发难治性急性淋巴细胞白血病中的研究进展

doi:10.7499/j.issn.1008-8830.2210056

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Abstract At present, the treatment of refractory/relapsed acute lymphoblastic leukemia is still in a difficult situation, and even if the intensity of chemotherapy is increased or it is combined with hematopoietic stem cell transplantation, some children may have a poor prognosis and a short survival time. Chimeric antigen receptor T-cell (CAR-T) immunotherapy uses genetically engineered T cells and does not rely on the human leukocyte antigen pathway to recognize tumor-specific antigens, and then CAR-T cells bind to target antigen cells to trigger immune response, thereby exerting a sustained anti-leukemia effect. As the most rapidly developed tumor immunotherapy, major breakthroughs have been made for CAR-T cells in the treatment of various hematological tumors, but there still lacks a comprehensive system for the research, development, and production of CAR-T cells and standardized diagnosis and treatment protocols in China. This article reviews the recent research on CAR-T cells in children with refractory/relapsed acute lymphoblastic leukemia.

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	WEI Nan
	CHEN Tian-Ping

Key words： Acute lymphoblastic leukemia Chimeric antigen receptor T cell Immunotherapy Child

Received: 12 October 2022

Cite this article:

WEI Nan,CHEN Tian-Ping. Recent research on chimeric antigen receptor T cells in children with refractory/relapsed acute lymphoblastic leukemia[J]. CJCP, 2023, 25(2): 210-216.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2210056 OR http://www.zgddek.com/EN/Y2023/V25/I2/210

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