Recent research on cytokines associated with anti-N-methyl-D-aspartate receptor encephalitis
ZHENG Ya-Xin, JIANG Li
Department of Neurology, Children's Hospital of Chongqing Medical University/National Clinical Research Center for Child Health and Disorders/Ministry of Education Key Laboratory of Child Development and Disorders/Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China
Abstract Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune inflammatory disease of the central nervous system, and little is known about its immune mechanism at present. There is a lack of disease-related biomarkers in cerebrospinal fluid except anti-NMDAR antibody, which leads to delayed diagnosis and treatment in some patients. Therefore, there has been an increasing number of studies on related cytokines in recent years to assess whether they can be used as new biomarkers for evaluating disease conditions and assisting diagnosis and treatment. Current studies have shown that some cytokines may be associated with the progression of anti-NMDAR encephalitis, and this article reviews the research advances in such cytokines associated with anti-NMDAR encephalitis.
Dalmau J, Armangué T, Planagumà J, et al. An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models[J]. Lancet Neurol, 2019, 18(11): 1045-1057. PMID: 31326280. DOI: 10.1016/S1474-4422(19)30244-3.
Li X, Hou C, Wu WL, et al. Pediatric anti-N-methyl-d-aspartate receptor encephalitis in southern China: analysis of 111 cases[J]. J Neuroimmunol, 2021, 352: 577479. PMID: 33486307. DOI: 10.1016/j.jneuroim.2021.577479.
Bost C, Chanson E, Picard G, et al. Malignant tumors in autoimmune encephalitis with anti-NMDA receptor antibodies[J]. J Neurol, 2018, 265(10): 2190-2200. PMID: 30003358. DOI: 10.1007/s00415-018-8970-0.
Armangue T, Spatola M, Vlagea A, et al. Frequency, symptoms, risk factors, and outcomes of autoimmune encephalitis after herpes simplex encephalitis: a prospective observational study and retrospective analysis[J]. Lancet Neurol, 2018, 17(9): 760-772. PMID: 30049614. PMCID: PMC6128696. DOI: 10.1016/S1474-4422(18)30244-8.
Zrzavy T, Endmayr V, Bauer J, et al. Neuropathological variability within a spectrum of NMDAR-encephalitis[J]. Ann Neurol, 2021, 90(5): 725-737. PMID: 34562035. DOI: 10.1002/ana.26223.
Wagnon I, Hélie P, Bardou I, et al. Autoimmune encephalitis mediated by B-cell response against N-methyl-d-aspartate receptor[J]. Brain, 2020, 143(10): 2957-2972. PMID: 32893288. DOI: 10.1093/brain/awaa250.
Chetaille Nézondet AL, Poubelle PE, Pelletier M. The evaluation of cytokines to help establish diagnosis and guide treatment of autoinflammatory and autoimmune diseases[J]. J Leukoc Biol, 2020, 108(2): 647-657. PMID: 32040246. DOI: 10.1002/JLB.5MR0120-218RRR.
Alawdi SH, El-Denshary ES, Safar MM, et al. Neuroprotective effect of nanodiamond in Alzheimer's disease rat model: a pivotal role for modulating NF-κB and STAT3 signaling[J]. Mol Neurobiol, 2017, 54(3): 1906-1918. PMID: 26897372. DOI: 10.1007/s12035-016-9762-0.
Li Q, Chen J, Yin M, et al. High level of soluble CD146 in cerebrospinal fluid might be a biomarker of severity of anti-N-methyl-D-Aspartate receptor encephalitis[J]. Front Immunol, 2021, 12: 680424. PMID: 34220828. PMCID: PMC8245058. DOI: 10.3389/fimmu.2021.680424.
Wang X, Ma C, Liu CY, et al. Neuronal NMDAR currents of the hippocampus and learning performance in autoimmune anti-NMDAR encephalitis and involvement of TNF-α and IL-6[J]. Front Neurol, 2019, 10: 684. PMID: 31297084. PMCID: PMC6607466. DOI: 10.3389/fneur.2019.00684.
Regen T, Isaac S, Amorim A, et al. IL-17 controls central nervous system autoimmunity through the intestinal microbiome[J]. Sci Immunol, 2021, 6(56): eaaz6563. PMID: 33547052. DOI: 10.1126/sciimmunol.aaz6563.
Zeng C, Chen L, Chen B, et al. Th17 cells were recruited and accumulated in the cerebrospinal fluid and correlated with the poor prognosis of anti-NMDAR encephalitis[J]. Acta Biochim Biophys Sin (Shanghai), 2018, 50(12): 1266-1273. PMID: 30418472. DOI: 10.1093/abbs/gmy137.
Balasa R, Bianca C, Septimiu V, et al. The matrix metalloproteinases panel in multiple sclerosis patients treated with natalizumab: a possible answer to natalizumab non- responders[J]. CNS Neurol Disord Drug Targets, 2018, 17(6): 464-472. PMID: 29968546. DOI: 10.2174/1871527317666180703102536.
Reich K, Warren RB, Lebwohl M, et al. Bimekizumab versus secukinumab in Plaque Psoriasis[J]. N Engl J Med, 2021, 385(2): 142-152. PMID: 33891380. DOI: 10.1056/NEJMoa2102383.
Murray PJ. Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response[J]. Curr Opin Pharmacol, 2006, 6(4): 379-386. PMID: 16713356. DOI: 10.1016/j.coph.2006.01.010.
Eckman EA, Clausen DM, Herdt AR, et al. Specificity and diagnostic utility of cerebrospinal fluid CXCL13 in Lyme neuroborreliosis[J]. Clin Infect Dis, 2021, 72(10): 1719-1726. PMID: 32221538. DOI: 10.1093/cid/ciaa335.
Barstad B, Henningsson AJ, Tveitnes D, et al. Cerebrospinal fluid cytokines and chemokines in children with Lyme neuroborreliosis; pattern and diagnostic utility[J]. Cytokine, 2020, 130: 155023. PMID: 32199247. DOI: 10.1016/j.cyto.2020.155023.
Li Y, Yang K, Zhang F, et al. Identification of cerebrospinal fluid biomarker candidates for anti-N-methyl-D-aspartate receptor encephalitis: high-throughput proteomic investigation[J]. Front Immunol, 2022, 13: 971659. PMID: 36389787. PMCID: PMC9643472. DOI: 10.3389/fimmu.2022.971659.
Kothur K, Wienholt L, Mohammad SS, et al. Utility of CSF cytokine/chemokines as markers of active intrathecal inflammation: comparison of demyelinating, anti-NMDAR and enteroviral encephalitis[J]. PLoS One, 2016, 11(8): e0161656. PMID: 27575749. PMCID: PMC5004915. DOI: 10.1371/journal.pone.0161656.
Liu B, Liu J, Sun H, et al. Autoimmune encephalitis after Japanese encephalitis in children: a prospective study[J]. J Neurol Sci, 2021, 424: 117394. PMID: 33773410. DOI: 10.1016/j.jns.2021.117394.
Dai S, Liu F, Qin Z, et al. Kupffer cells promote T-cell hepatitis by producing CXCL10 and limiting liver sinusoidal endothelial cell permeability[J]. Theranostics, 2020, 10(16): 7163-7177. PMID: 32641985. PMCID: PMC7330839. DOI: 10.7150/thno.44960.
Nohejlova H, Kayserova J, Capek V, et al. Paediatric onset of multiple sclerosis: analysis of chemokine and cytokine levels in the context of the early clinical course[J]. Mult Scler Relat Disord, 2020, 46: 102467. PMID: 32889374. DOI: 10.1016/j.msard.2020.102467.
Shaul ME, Zlotnik A, Tidhar E, et al. Tumor-associated neutrophils drive B-cell recruitment and their differentiation to plasma cells[J]. Cancer Immunol Res, 2021, 9(7): 811-824. PMID: 33906865. DOI: 10.1158/2326-6066.CIR-20-0839.
Smulski CR, Zhang L, Burek M, et al. Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells[J]. Cell Rep, 2022, 38(13): 110583. PMID: 35354034. DOI: 10.1016/j.celrep.2022.110583.
Baert L, Benkhoucha M, Popa N, et al. A proliferation-inducing ligand-mediated anti-inflammatory response of astrocytes in multiple sclerosis[J]. Ann Neurol, 2019, 85(3): 406-420. PMID: 30635946. DOI: 10.1002/ana.25415.
Deng B, Liu XN, Li X, et al. Raised cerebrospinal fluid BAFF and APRIL levels in anti-N-methyl-d-aspartate receptor encephalitis: correlation with clinical outcome[J]. J Neuroimmunol, 2017, 305: 84-91. PMID: 28284352. DOI: 10.1016/j.jneuroim.2017.01.012.
Furie R, Rovin BH, Houssiau F, et al. Two-year, randomized, controlled trial of belimumab in lupus nephritis[J]. N Engl J Med, 2020, 383(12): 1117-1128. PMID: 32937045. DOI: 10.1056/NEJMoa2001180.