急性淋巴细胞白血病儿童认知功能损害的临床研究进展

doi:10.7499/j.issn.1008-8830.2210063

Abstract
Figure/Table
References(55)
Related Citation (15)
Read Tracking
Download Tracking

Download: PDF (530 KB) HTML
Export: BibTeX | EndNote (RIS) Supporting Info

Abstract Acute lymphoblastic leukemia (ALL) is the most common malignant neoplastic disease in children. With the continuous improvement in diagnosis and treatment, there has been an increasing number of ALL children who achieve long-term survival after complete remission; however, a considerable proportion of these children have cognitive impairment, which has a serious adverse impact on their learning, employment, and social life. This article reviews the latest research on cognitive impairment in children with ALL from the aspects of the influencing factors, detection techniques, and prevention/treatment methods for cognitive impairment.

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	QIN Li-Jiao
	MAI Hui-Rong

Key words： Acute lymphoblastic leukemia Cognitive function Influencing factor Child

Received: 15 October 2022

Cite this article:

QIN Li-Jiao,MAI Hui-Rong. Recent research on cognitive impairment in children with acute lymphoblastic leukemia[J]. CJCP, 2023, 25(3): 315-320.

URL:

http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2210063 OR http://www.zgddek.com/EN/Y2023/V25/I3/315

	1 汤静燕. 儿童常见肿瘤诊断治疗的进步[J]. 中国小儿血液与肿瘤杂志, 2020, 25(6): 313-315. DOI: 10.3969/j.issn.1673-5323.2020.06.001.
	傅晓燕, 谢晓恬, 赵焱. 长期无病生存急性淋巴细胞白血病儿童神经认知功能及影响因素的研究[J]. 中国当代儿科杂志, 2017, 19(8): 899-903. PMID: 28774365. PMCID: PMC7390049. DOI: 10.7499/j.issn.1008-8830.2017.08.010.
	Krull KR, Brinkman TM, Li C, et al. Neurocognitive outcomes decades after treatment for childhood acute lymphoblastic leukemia: a report from the St Jude lifetime cohort study[J]. J Clin Oncol, 2013, 31(35): 4407-4415. PMID: 24190124. PMCID: PMC3842908. DOI: 10.1200/JCO.2012.48.2315.
	An H, Lee S. Difficulty in returning to school among adolescent leukemia survivors: a qualitative descriptive study[J]. Eur J Oncol Nurs, 2019, 38: 70-75. PMID: 30717939. DOI: 10.1016/j.ejon.2018.12.008.
	Gogtay N, Giedd JN, Lusk L, et al. Dynamic mapping of human cortical development during childhood through early adulthood[J]. Proc Natl Acad Sci U S A, 2004, 101(21): 8174-8179. PMID: 15148381. PMCID: PMC419576. DOI: 10.1073/pnas.0402680101.
	Hardy KK, Embry L, Kairalla JA, et al. Neurocognitive functioning of children treated for high-risk B-acute lymphoblastic leukemia randomly assigned to different methotrexate and corticosteroid treatment strategies: a report from the children's oncology group[J]. J Clin Oncol, 2017, 35(23): 2700-2707. PMID: 28671857. PMCID: PMC5549456. DOI: 10.1200/JCO.2016.71.7587.
	Lofstad GE, Reinfjell T, Weider S, et al. Neurocognitive outcome and compensating possibilities in children and adolescents treated for acute lymphoblastic leukemia with chemotherapy only[J]. Front Psychol, 2019, 10: 1027. PMID: 31156497. PMCID: PMC6532365. DOI: 10.3389/fpsyg.2019.01027.
	Sherief LM, Sanad R, ElHaddad A, et al. A cross-sectional study of two chemotherapy protocols on long term neurocognitive functions in Egyptian children surviving acute lymphoblastic leukemia[J]. Curr Pediatr Rev, 2018, 14(4): 253-260. PMID: 30381081. PMCID: PMC6416189. DOI: 10.2174/1573396314666181031134919.
	Chiou SS, Lin PC, Liao YM, et al. A cross-sectional follow-up study of physical morbidities, neurocognitive function, and attention problems in post-treatment childhood acute lymphoblastic leukemia survivors[J]. Kaohsiung J Med Sci, 2019, 35(6): 373-378. PMID: 30913362. DOI: 10.1002/kjm2.12061.
	Partanen M, Phipps S, Russell K, et al. Longitudinal trajectories of neurocognitive functioning in childhood acute lymphoblastic leukemia[J]. J Pediatr Psychol, 2021, 46(2): 168-178. PMID: 33011782. PMCID: PMC7896273. DOI: 10.1093/jpepsy/jsaa086.
	Gandy K, Scoggins MA, Phillips N, et al. Sex-based differences in functional brain activity during working memory in survivors of pediatric acute lymphoblastic leukemia[J]. JNCI Cancer Spectr, 2022, 6(2): pkac026. PMID: 35603857 PMCID:PMC9041337. DOI: 10.1093/jncics/pkac026.
	van der Plas E, Qiu W, Nieman BJ, et al. Sex-specific associations between chemotherapy, chronic conditions, and neurocognitive impairment in acute lymphoblastic leukemia survivors: a report from the childhood cancer survivor study[J]. J Natl Cancer Inst, 2021, 113(5): 588-596. PMID: 32882041. PMCID: PMC8096369. DOI: 10.1093/jnci/djaa136.
	Pullen BJ, Oliver JL, Lloyd RS, et al. Relationships between athletic motor skill competencies and maturity, sex, physical performance, and psychological constructs in boys and girls[J]. Children (Basel), 2022, 9(3): 375. PMID: 35327747. PMCID: PMC8947559. DOI: 10.3390/children9030375.
	Frere PB, Vetter NC, Artiges E, et al. Sex effects on structural maturation of the limbic system and outcomes on emotional regulation during adolescence[J]. Neuroimage, 2020, 210: 116441. PMID: 31811901. DOI: 10.1016/j.neuroimage.2019.116441.
	Wengenroth L, Sommer G, Schindler M, et al. Income in adult survivors of childhood cancer[J]. PLoS One, 2016, 11(5): e0155546. PMID: 27213682. PMCID: PMC4877063. DOI: 10.1371/journal.pone.0155546.
	Dumas A, Berger C, Auquier P, et al. Educational and occupational outcomes of childhood cancer survivors 30 years after diagnosis: a French cohort study[J]. Br J Cancer, 2016, 114(9): 1060-1068. PMID: 27115571. PMCID: PMC4984908. DOI: 10.1038/bjc.2016.62.
	Jacola LM, Conklin HM, Krull KR, et al. The impact of intensified CNS-directed therapy on neurocognitive outcomes in survivors of childhood acute lymphoblastic leukemia treated without cranial irradiation[J]. J Clin Oncol, 2022, 40(36): 4218-4227. PMID: 36322880. DOI: 10.1200/JCO.22.00263.
	Jacola LM, Krull KR, Pui CH, et al. Longitudinal assessment of neurocognitive outcomes in survivors of childhood acute lymphoblastic leukemia treated on a contemporary chemotherapy protocol[J]. J Clin Oncol, 2016, 34(11): 1239-1247. PMID: 26858334. PMCID: PMC4872325. DOI: 10.1200/JCO.2015.64.3205.
	Mulrooney DA, Hyun G, Ness KK, et al. The changing burden of long-term health outcomes in survivors of childhood acute lymphoblastic leukaemia: a retrospective analysis of the St Jude lifetime cohort study[J]. Lancet Haematol, 2019, 6(6): e306-e316. PMID: 31078468. PMCID: PMC6756152. DOI: 10.1016/S2352-3026(19)30050-X.
	Schroyen G, Meylaers M, Deprez S, et al. Prevalence of leukoencephalopathy and its potential cognitive sequelae in cancer patients[J]. J Chemother, 2020, 32(7): 327-343. PMID: 32799637. DOI: 10.1080/1120009X.2020.1805239.
	Fellah S, Cheung YT, Scoggins MA, et al. Brain activity associated with attention deficits following chemotherapy for childhood acute lymphoblastic leukemia[J]. J Natl Cancer Inst, 2019, 111(2): 201-209. PMID: 29790971. PMCID: PMC6376909. DOI: 10.1093/jnci/djy089.
	Daetwyler E, Bargetzi M, Otth M, et al. Late effects of high-dose methotrexate treatment in childhood cancer survivors: a systematic review[J]. BMC Cancer, 2022, 22(1): 267. PMID: 35287628. PMCID: PMC8919635. DOI: 10.1186/s12885-021-09145-0.
	Osborne DM, Pearson-Leary J, McNay EC. The neuroenergetics of stress hormones in the hippocampus and implications for memory[J]. Front Neurosci, 2015, 9: 164. PMID: 25999811. PMCID: PMC4422005. DOI: 10.3389/fnins.2015.00164.
	Phillips NS, Cheung YT, Glass JO, et al. Neuroanatomical abnormalities related to dexamethasone exposure in survivors of childhood acute lymphoblastic leukemia[J]. Pediatr Blood Cancer, 2020, 67(3): e27968. PMID: 31407461. PMCID: PMC6980878. DOI: 10.1002/pbc.27968.
	Phillips NS, Kesler SR, Scoggins MA, et al. Connectivity of the cerebello-thalamo-cortical pathway in survivors of childhood leukemia treated with chemotherapy only[J]. JAMA Netw Open, 2020, 3(11): e2025839. PMID: 33216140. PMCID: PMC7679952. DOI: 10.1001/jamanetworkopen.2020.25839.
	Lenfant C, Greiner N, Duprez T. Cytarabine-induced encephalitis[J]. J Belg Soc Radiol, 2021, 105(1): 46. PMID: 34611580. PMCID: PMC8447975. DOI: 10.5334/jbsr.2492.
	Millan NC, Pastrana A, Guitter MR, et al. Acute and sub-acute neurological toxicity in children treated for acute lymphoblastic leukemia[J]. Leuk Res, 2018, 65: 86-93. PMID: 29328996. DOI: 10.1016/j.leukres.2017.12.010.
	Adil MK, Ali Z, Arshad U, et al. Vincristine induced neurotoxicity in children who underwent chemotherapy for acute lymphoblastic leukemia and Wilms tumor[J]. Pak J Med Sci, 2021, 37(5): 1331-1334. PMID: 34475907. PMCID: PMC8377900. DOI: 10.12669/pjms.37.5.4169.
	Yang QY, Hu YH, Guo HL, et al. Vincristine-induced peripheral neuropathy in childhood acute lymphoblastic leukemia: genetic variation as a potential risk factor[J]. Front Pharmacol, 2021, 12: 771487. PMID: 34955843. PMCID: PMC8696478. DOI: 10.3389/fphar.2021.771487.
	Peng L, Yang LS, Yam P, et al. Neurocognitive and behavioral outcomes of Chinese survivors of childhood lymphoblastic leukemia[J]. Front Oncol, 2021, 11: 655669. PMID: 33959507. PMCID: PMC8093634. DOI: 10.3389/fonc.2021.655669.
	Gandy K, Scoggins MA, Jacola LM, et al. Structural and functional brain imaging in long-term survivors of childhood acute lymphoblastic leukemia treated with chemotherapy: a systematic review[J]. JNCI Cancer Spectr, 2021, 5(5): pkab069. PMID: 34514328. PMCID: PMC8421809. DOI: 10.1093/jncics/pkab069.
	Follin C, Sv?rd D, van Westen D, et al. Microstructural white matter alterations associated to neurocognitive deficits in childhood leukemia survivors treated with cranial radiotherapy: a diffusional kurtosis study[J]. Acta Oncol, 2019, 58(7): 1021-1028. PMID: 30747019. DOI: 10.1080/0284186X.2019.1571279.
	Wei K, Liang Y, Yang B, et al. An observational MRI study of methotrexate-treated children with acute lymphoblastic leukemia in remission and subtle cognitive decline[J]. Quant Imaging Med Surg, 2022, 12(4): 2474-2486. PMID: 35371933. PMCID: PMC8923847. DOI: 10.21037/qims-21-748.
	Follin C, Erfurth EM, Johansson A, et al. Impaired brain metabolism and neurocognitive function in childhood leukemia survivors despite complete hormone supplementation in adulthood[J]. Psychoneuroendocrinology, 2016, 73: 157-165. PMID: 27498291. DOI: 10.1016/j.psyneuen.2016.07.222.
	Stefancin P, Cahaney C, Parker RI, et al. Neural correlates of working memory function in pediatric cancer survivors treated with chemotherapy: an fMRI study[J]. NMR Biomed, 2020, 33(6): e4296. PMID: 32215994. DOI: 10.1002/nbm.4296.
	Kesler SR, Ogg R, Reddick WE, et al. Brain network connectivity and executive function in long-term survivors of childhood acute lymphoblastic leukemia[J]. Brain Connect, 2018, 8(6): 333-342. PMID: 29936880. PMCID: PMC6103246. DOI: 10.1089/brain.2017.0574.
	Ikonomidou C. Cerebrospinal fluid biomarkers in childhood leukemias[J]. Cancers (Basel), 2021, 13(3): 438. PMID: 33498882. PMCID: PMC7866046. DOI: 10.3390/cancers13030438.
	Schraw JM, Woodhouse JP, Bernhardt MB, et al. Comparison of the blood, bone marrow, and cerebrospinal fluid metabolomes in children with b-cell acute lymphoblastic leukemia[J]. Sci Rep, 2021, 11(1): 19613. PMID: 34608220. PMCID: PMC8490393. DOI: 10.1038/s41598-021-99147-6.
	Cheung YT, Khan RB, Liu W, et al. Association of cerebrospinal fluid biomarkers of central nervous system injury with neurocognitive and brain imaging outcomes in children receiving chemotherapy for acute lymphoblastic leukemia[J]. JAMA Oncol, 2018, 4(7): e180089. PMID: 29596541. PMCID: PMC5885182. DOI: 10.1001/jamaoncol.2018.0089.
	Elens I, Deprez S, Danckaerts M, et al. Neurocognitive sequelae in adult childhood leukemia survivors related to levels of phosphorylated Tau[J]. J Natl Cancer Inst, 2017, 109(7): djw321. PMID: 29982754. DOI: 10.1093/jnci/djw321.
	Godoy PBG, Simionato NM, de Mello CB, et al. Assessment of executive functions after treatment of childhood acute lymphoid leukemia: a systematic review[J]. Neuropsychol Rev, 2020, 30(3): 386-406. PMID: 32720195. DOI: 10.1007/s11065-020-09446-4.
	42 Kautiainen R, Aleksonis H, King TZ. A systematic review of host genomic variation and neuropsychological outcomes for pediatric cancer survivors[J]. Neuropsychol Rev, 2022. PMID: 35305234. Epub ahead of print. DOI: 10.1007/s11065-022-09539-2.
	Elens I, Deprez S, Billiet T, et al. Methylene tetrahydrofolate reductase A1298C polymorphisms influence the adult sequelae of chemotherapy in childhood-leukemia survivors[J]. PLoS One, 2021, 16(4): e0250228. PMID: 33930029. PMCID: PMC8087097. DOI: 10.1371/journal.pone.0250228.
	Kamdar KY, Krull KR, El-Zein RA, et al. Folate pathway polymorphisms predict deficits in attention and processing speed after childhood leukemia therapy[J]. Pediatr Blood Cancer, 2011, 57(3): 454-460. PMID: 21618410. PMCID: PMC3134130. DOI: 10.1002/pbc.23162.
	Al-Mahayri ZN, Patrinos GP, Ali BR. Pharmacogenomics in pediatric acute lymphoblastic leukemia: promises and limitations[J]. Pharmacogenomics, 2017, 18(7): 687-699. PMID: 28468529. DOI: 10.2217/pgs-2017-0005.
	Hagan AJ, Verity SJ. The influence of methylphenidate on sustained attention in paediatric acquired brain injury: a meta-analytical review[J]. Child Neuropsychol, 2022. Epub ahead of print. PMID: 36000579. DOI: 10.1080/09297049.2022.2112559.
	Conklin HM, Helton S, Ashford J, et al. Predicting methylphenidate response in long-term survivors of childhood cancer: a randomized, double-blind, placebo-controlled, crossover trial[J]. J Pediatr Psychol, 2010, 35(2): 144-155. PMID: 19465537. PMCID: PMC2902831. DOI: 10.1093/jpepsy/jsp044.
	Greenhill LL, Swanson JM, Vitiello B, et al. Impairment and deportment responses to different methylphenidate doses in children with ADHD: the MTA titration trial[J]. J Am Acad Child Adolesc Psychiatry, 2001, 40(2): 180-187. PMID: 11211366. DOI: 10.1097/00004583-200102000-00012.
	Verity SJ, Bell L, Ryles J, et al. "I feel happy again": methylphenidate supports health-related quality of life in survivors of pediatric brain tumor[J]. Children (Basel), 2022, 9(7): 1058. PMID: 35884042. PMCID: PMC9322883. DOI: 10.3390/children9071058.
	Bai L, Yu E. A narrative review of risk factors and interventions for cancer-related cognitive impairment[J]. Ann Transl Med, 2021, 9(1): 72. PMID: 33553365. PMCID: PMC7859819. DOI: 10.21037/atm-20-6443.
	Lawrence JA, Griffin L, Balcueva EP, et al. A study of donepezil in female breast cancer survivors with self-reported cognitive dysfunction 1 to 5 years following adjuvant chemotherapy[J]. J Cancer Surviv, 2016, 10(1): 176-184. PMID: 26130292. PMCID: PMC4930878. DOI: 10.1007/s11764-015-0463-x.
	Wong TY, Chang YT, Wang MY, et al. The effectiveness of child-centered play therapy for executive functions in children with attention-deficit/hyperactivity disorder[J]. Clin Child Psychol Psychiatry, 2022. Epub ahead of print. PMID: 36125333. DOI: 10.1177/13591045221128399.
	53 柯晓燕, 徐秀, 陈立, 等. 学龄前注意缺陷多动障碍儿童实施行为管理的专家共识[J]. 中国循证儿科杂志, 2022, 17(4): 274-280. DOI: 10.3969/j.issn.1673-5501.2022.04.003.
	Coelho LF, Barbosa DL, Rizzutti S, et al. Use of cognitive behavioral therapy and token economy to alleviate dysfunctional behavior in children with attention-deficit hyperactivity disorder[J]. Front Psychiatry, 2015, 6: 167. PMID: 26635642. PMCID: PMC4659172. DOI: 10.3389/fpsyt.2015.00167.
	Wogksch MD, Goodenough CG, Finch ER, et al. Physical activity and fitness in childhood cancer survivors: a scoping review[J]. Aging Cancer, 2021, 2(4): 112-128. PMID: 35098147. PMCID: PMC8794406. DOI: 10.1002/aac2.12042.