胎龄<34周早产儿一氧化氮吸入的研究进展

doi:10.7499/j.issn.1008-8830.2303146

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Abstract Nitric oxide is a messenger molecule for vasodilation of vascular smooth muscle cells, and inhaled nitric oxide (iNO) can dilate pulmonary blood vessels and reduce pulmonary vascular resistance, thereby reducing pulmonary artery pressure, but with no influence on systemic circulation pressure. Guidelines in China and overseas recommend the use of iNO in full-term infants and late preterm infants, and it has been proved that it has a marked effect on persistent pulmonary hypertension and hypoxic respiratory failure in such infants. However, recent studies have shown that there is an increase in the off-label use of iNO in preterm infants with a gestational age of <34 weeks. This article reviews the research progress on the efficacy, safety, timing, dose, and withdrawal mode of iNO and its combination with vasoactive drugs in the treatment of preterm infants with a gestational age of <34 weeks in China and overseas, so as to provide a reference for clinical application.

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	LIANG Guo-Bao
	LIN Xin-Zhu

Key words： Nitric oxide Pulmonary hypertension Hypoxic respiratory failure Efficacy Preterm infant

Received: 31 March 2023

Corresponding Authors: (Lin X-Z, Email:xinzhufj@163.com) E-mail: xinzhufj@163.com

Cite this article:

LIANG Guo-Bao,LIN Xin-Zhu. Recent research on inhaled nitric oxide in preterm infants with a gestational age of <34 weeks[J]. CJCP, 2023, 25(9): 982-988.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2303146 OR http://www.zgddek.com/EN/Y2023/V25/I9/982

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