Comparison of the impact of different fat emulsions on clinical outcomes in preterm infants with varying duration of parenteral nutrition: a randomized controlled multicenter study

LIN Rong, YANG Qing, WANG Ya-Sen, SHEN Wei, LIN Xin-Zhu, SONG Si-Yu, KONG Juan, WU Fan, YANG Dong, BAI Rui-Miao, LI Zhan-Kui, SONG Shi-Rong, YU Wen-Ting, MAO Jian, ZHANG Yi-Jia, ZHANG Juan, TONG Xiao-Mei

Chinese Journal of Contemporary Pediatrics ›› 2023, Vol. 25 ›› Issue (9) : 901-908.

PDF(651 KB)
PDF(651 KB)
Chinese Journal of Contemporary Pediatrics ›› 2023, Vol. 25 ›› Issue (9) : 901-908. DOI: 10.7499/j.issn.1008-8830.2303074
CLINICAL RESEARCH

Comparison of the impact of different fat emulsions on clinical outcomes in preterm infants with varying duration of parenteral nutrition: a randomized controlled multicenter study

  • LIN Rong1, YANG Qing1, WANG Ya-Sen1, SHEN Wei1, LIN Xin-Zhu1, SONG Si-Yu2, KONG Juan2, WU Fan2, YANG Dong3, BAI Rui-Miao3, LI Zhan-Kui3, SONG Shi-Rong4, YU Wen-Ting4, MAO Jian4, ZHANG Yi-Jia5, ZHANG Juan5, TONG Xiao-Mei5
Author information +
History +

Abstract

Objective To compare the impact of two types of fat emulsion on clinical outcomes in preterm infants with varying duration of parenteral nutrition (PN). Methods Preterm infants meeting the inclusion criteria were randomly assigned to two groups: medium/long-chain triglyceride fat emulsion (referred to as MCT/LCT) group or multi-oil fat emulsion (containing soybean oil, medium-chain triglycerides, olive oil, and fish oil; referred to as SMOF) group. The infants were stratified into groups based on the duration of PN (15-21 days, 22-28 days, and ≥29 days). Clinical characteristics, nutritional status, biochemical indicators, and clinical outcomes were compared between the two groups. Results Compared with the MCT/LCT group, the SMOF group had lower peak levels of triglyceride during the hospital stay in preterm infants with PN of 15-21 days, 22-28 days, and ≥29 days, respectively (P<0.05). Logistic regression trend analysis showed that with a longer duration of PN, the risk of parenteral nutrition-associated cholestasis (PNAC) and bronchopulmonary dysplasia (BPD) significantly increased in the MCT/LCT group (P<0.05), while the risk of brain injury did not significantly change (P>0.05). In the SMOF group, the risks of PNAC and BPD did not significantly change with a longer duration of PN (P>0.05), but the risk of brain injury significantly decreased (P=0.006). Conclusions Compared to MCT/LCT, SMOF have better lipid tolerance. With a longer duration of PN, SMOF does not increase the risks of PNAC and BPD and had a protective effect against brain injury. This suggests that in preterm infants requiring long-term PN, the use of SMOF is superior to MCT/LCT.

Key words

Parenteral nutrition-associated cholestasis / Fat emulsion / Nutrition / Randomized controlled trial / Preterm infant

Cite this article

Download Citations
LIN Rong, YANG Qing, WANG Ya-Sen, SHEN Wei, LIN Xin-Zhu, SONG Si-Yu, KONG Juan, WU Fan, YANG Dong, BAI Rui-Miao, LI Zhan-Kui, SONG Shi-Rong, YU Wen-Ting, MAO Jian, ZHANG Yi-Jia, ZHANG Juan, TONG Xiao-Mei. Comparison of the impact of different fat emulsions on clinical outcomes in preterm infants with varying duration of parenteral nutrition: a randomized controlled multicenter study[J]. Chinese Journal of Contemporary Pediatrics. 2023, 25(9): 901-908 https://doi.org/10.7499/j.issn.1008-8830.2303074
PDF(651 KB)

Accesses

Citation

Detail

Sections
Recommended

/