血小板与淋巴细胞比值对中国川崎病患儿冠状动脉病变预测价值的Meta分析

doi:10.7499/j.issn.1008-8830.2306097

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Abstract Objective To systematically evaluate the value of the platelet-to-lymphocyte ratio (PLR) in predicting coronary artery lesions (CAL) in Chinese children with Kawasaki Disease (KD). Methods A comprehensive search was conducted in databases including PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang Data, China Biomedical Literature Database, and China Science and Technology Journal Database from inception to December 2022. The quality of the included literature was assessed using the Newcastle-Ottawa Scale, and a Meta analysis was performed using Stata 15.1. Results A total of ten published reports, involving 3 664 Chinese children with KD, were included in this Meta analysis, of whom 1 328 developed CAL. The Meta analysis revealed a sensitivity of 0.78 (95%CI: 0.71-0.83), specificity of 0.71 (95%CI: 0.61-0.80), overall diagnostic odds ratio of 8.69 (95%CI: 5.02-15.06), and an area under the curve of the summary receiver operating characteristic of 0.82 (95%CI: 0.78-0.85) for PLR in predicting CAL in the children with KD. The sensitivity, specificity, and area under the curve of summary receiver operating characteristic were lower for PLR alone compared to PLR in combination with other indicators. Sensitivity analysis demonstrated the stability of the Meta analysis results with no significant changes upon excluding individual studies. However, a significant publication bias was observed (P<0.001). Conclusions PLR demonstrates certain predictive value for CAL in Chinese children with KD.

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	LI Yan-Yu
	YUAN Chen-Chen
	CAI Ai-Yuan
	ZHOU Bo-Ju
	HUANG Teng

Key words： Kawasaki disease Platelet-to-lymphocyte ratio Coronary artery lesion Meta analysis Child

Received: 19 June 2023

Cite this article:

LI Yan-Yu,YUAN Chen-Chen,CAI Ai-Yuan et al. Platelet-to-lymphocyte ratio as a biomarker for predicting coronary artery lesions in Chinese children with Kawasaki disease: a Meta analysis[J]. CJCP, 2023, 25(12): 1219-1226.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2306097 OR http://www.zgddek.com/EN/Y2023/V25/I12/1219

	McCrindle BW, Rowley AH, Newburger JW, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: a scientific statement for health professionals from the American Heart Association[J]. Circulation, 2017, 135(17): e927-e999. PMID: 28356445. DOI: 10.1161/CIR.0000000000000484.
	Fukazawa R, Kobayashi J, Ayusawa M, et al. JCS/JSCS 2020 guideline on diagnosis and management of cardiovascular sequelae in Kawasaki disease[J]. Circ J, 2020, 84(8): 1348-1407. PMID: 32641591. DOI: 10.1253/circj.CJ-19-1094.
	Muta H, Ishii M, Furui J, et al. Risk factors associated with the need for additional intravenous gamma-globulin therapy for Kawasaki disease[J]. Acta Paediatr, 2006, 95(2): 189-193. PMID: 16449025. DOI: 10.1080/08035250500327328.
	Li XT, Fang H, Li D, et al. Association of platelet to lymphocyte ratio with in-hospital major adverse cardiovascular events and the severity of coronary artery disease assessed by the Gensini score in patients with acute myocardial infarction[J]. Chin Med J (Engl), 2020, 133(4): 415-423. PMID: 31977557. PMCID: PMC7046248. DOI: 10.1097/CM9.0000000000000650.
	Gasparyan AY, Ayvazyan L, Mukanova U, et al. The platelet-to-lymphocyte ratio as an inflammatory marker in rheumatic diseases[J]. Ann Lab Med, 2019, 39(4): 345-357. PMID: 30809980. PMCID: PMC6400713. DOI: 10.3343/alm.2019.39.4.345.
	6 陈芃螈, 杨超, 李刚, 等. 系统性免疫-炎症指数对川崎病患儿冠脉扩张的预测价值[J]. 中国免疫学杂志, 2020, 36(16): 2003-2006. DOI: 10.3969/j.issn.1000-484X.2020.16.017.
	7 何雪婷. 外周血参数及血小板参数对川崎病冠状动脉损害的预测价值[D]. 乌鲁木齐: 新疆医科大学, 2022.
	8 李敏. 外周血细胞参数对不同年龄患儿完全川崎病冠状动脉损伤的预测意义[D]. 遵义: 遵义医科大学, 2022.
	9 石莉. ANCA, NLR及PLR在川崎病中的临床意义[D]. 南昌: 南昌大学, 2019.
	10 王晶晶. 外周血细胞比值NLR、PLR、SII在川崎病患儿中的水平变化及临床意义[D]. 沈阳: 沈阳医学院, 2022.
	11 王茜. 201例川崎病患儿临床特点及冠状动脉损害发生的危险因素分析[D]. 天津: 天津医科大学, 2019.
	12 张书婉, 黄君华, 吴文婧, 等. 外周血NLR与PLR对儿童完全型川崎病冠状动脉损伤的预测分析[J]. 现代检验医学杂志, 2020, 35(6): 38-41. DOI: 10.3969/j.issn.1671-7414.2020.06.010.
	13 王菲. 外周血细胞比值MPVLR、NLR、PLR在川崎病诊断中的价值[D]. 兰州: 兰州大学, 2019.
	14 李敏, 邵晓珊. 急性期外周血NLR、PLR及MPVLR对完全川崎病患儿冠状动脉扩张和丙种球蛋白抵抗的预测价值[J]. 贵州医科大学学报, 2022, 47(3): 318-323. DOI: 10.19367/j.cnki.2096-8388.2022.03.013.
	15 王思茹. 川崎病冠状动脉病变的预测分析[D]. 重庆: 重庆医科大学, 2022.
	Du ZD, Zhao D, Du J, et al. Epidemiologic study on Kawasaki disease in Beijing from 2000 through 2004[J]. Pediatr Infect Dis J, 2007, 26(5): 449-451. PMID: 17468660. DOI: 10.1097/01.inf.0000261196.79223.18.
	Xie LP, Yan WL, Huang M, et al. Epidemiologic features of Kawasaki disease in Shanghai from 2013 through 2017[J]. J Epidemiol, 2020, 30(10): 429-435. PMID: 31548437. PMCID: PMC7492704. DOI: 10.2188/jea.JE20190065.
	Chen S, Dong Y, Kiuchi MG, et al. Coronary artery complication in Kawasaki disease and the importance of early intervention: a systematic review and meta-analysis[J]. JAMA Pediatr, 2016, 170(12): 1156-1163. PMID: 27749951. DOI: 10.1001/jamapediatrics.2016.2055.
	Dionne A, Dahdah N. A decade of NT-proBNP in acute kawasaki disease, from physiological response to clinical relevance[J]. Children (Basel), 2018, 5(10): 141. PMID: 30322059. PMCID: PMC6210997. DOI: 10.3390/children5100141.
	Huang H, Dong J, Wang S, et al. Prediction model risk-of-bias assessment tool for coronary artery lesions in Kawasaki disease[J]. Front Cardiovasc Med, 2022, 9: 1014067. PMID: 36312287. PMCID: PMC9606216. DOI: 10.3389/fcvm.2022.1014067.
	Liu R, He B, Gao F, et al. Relationship between adipokines and coronary artery aneurysm in children with Kawasaki disease[J]. Transl Res, 2012, 160(2): 131-136. PMID: 22683371. DOI: 10.1016/j.trsl.2012.01.013.
	Harada K. Intravenous gamma-globulin treatment in Kawasaki disease[J]. Acta Paediatr Jpn, 1991, 33(6): 805-810. PMID: 1801561. DOI: 10.1111/j.1442-200x.1991.tb02612.x.
	Liu HH, Chen WX, Niu MM, et al. A new scoring system for coronary artery abnormalities in Kawasaki disease[J]. Pediatr Res, 2022, 92(1): 275-283. PMID: 34584222. PMCID: PMC8476714. DOI: 10.1038/s41390-021-01752-8.
	Sarejloo S, Shahri MM, Azami P, et al. Neutrophil to lymphocyte ratio as a biomarker for predicting the coronary artery abnormality in Kawasaki disease: a meta-analysis[J]. Dis Markers, 2022, 2022: 6421543. PMID: 36267460. PMCID: PMC9578863. DOI: 10.1155/2022/6421543.
	Nording HM, Seizer P, Langer HF. Platelets in inflammation and atherogenesis[J]. Front Immunol, 2015, 6: 98. PMID: 25798138. PMCID: PMC4351644. DOI: 10.3389/fimmu.2015.00098.
	Arora K, Guleria S, Jindal AK, et al. Platelets in Kawasaki disease: is this only a numbers game or something beyond?[J]. Genes Dis, 2020, 7(1): 62-66. PMID: 32181276. PMCID: PMC7063415. DOI: 10.1016/j.gendis.2019.09.003.
	Laurito M, Stazi A, Delogu AB, et al. Endothelial and platelet function in children with previous Kawasaki disease[J]. Angiology, 2014, 65(8): 716-722. PMID: 24019084. DOI: 10.1177/0003319713502392.
	Pietraforte D, Gambardella L, Marchesi A, et al. Platelets in Kawasaki patients: two different populations with different mitochondrial functions[J]. Int J Cardiol, 2014, 172(2): 526-528. PMID: 24491862. DOI: 10.1016/j.ijcard.2014.01.022.
	Jin J, Wang J, Lu Y, et al. Platelet-derived microparticles: a new index of monitoring platelet activation and inflammation in Kawasaki disease[J]. Indian J Pediatr, 2019, 86(3): 250-255. PMID: 30159809. DOI: 10.1007/s12098-018-2765-2.
	Yahata T, Suzuki C, Yoshioka A, et al. Platelet activation dynamics evaluated using platelet-derived microparticles in Kawasaki disease[J]. Circ J, 2014, 78(1): 188-193. PMID: 24152721. DOI: 10.1253/circj.cj-12-1037.
	Maric LS, Knezovic I, Papic N, et al. Risk factors for coronary artery abnormalities in children with Kawasaki disease: a 10-year experience[J]. Rheumatol Int, 2015, 35(6): 1053-1058. PMID: 25429794. DOI: 10.1007/s00296-014-3186-9.
	Urbanowicz T, Olasińska-Wi?niewska A, Michalak M, et al. The prognostic significance of neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR) and platelet to lymphocyte ratio (PLR) on long-term survival in off-pump coronary artery bypass grafting (OPCAB) procedures[J]. Biology (Basel), 2021, 11(1): 34. PMID: 35053032. PMCID: PMC8772913. DOI: 10.3390/biology11010034.
	Li W, Liu Q, Tang Y. Platelet to lymphocyte ratio in the prediction of adverse outcomes after acute coronary syndrome: a meta-analysis[J]. Sci Rep, 2017, 7: 40426. PMID: 28071752. PMCID: PMC5223131. DOI: 10.1038/srep40426.
	中华医学会儿科学分会心血管学组, 中华儿科杂志编辑委员会. 川崎病冠状动脉病变的临床处理建议（2020年修订版）[J]. 中华儿科杂志, 2020, 58(9): 718-724. PMID: 32872711. DOI: 10.3760/cma.j.cn112140-20200422-00421.