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CJCP  2023, Vol. 25 Issue (12): 1234-1238    DOI: 10.7499/j.issn.1008-8830.2308073
TOPIC OF KAWASAKI DISEASE Current Issue| Next Issue| Archive| Adv Search  | 
Research advances in genetic polymorphisms in Kawasaki disease
DONG Ming-Xing, WANG Xi-Xia, JIAO Fu-Yong, ZHANG Wei-Hua
Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712000, China/Xianyang Children's Hospital, Xianyang,Shaanxi 712000, China (Zhang W-H, Email: xiangyuelanda2006@126.com)
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Abstract  Kawasaki disease (KD) is a systemic inflammatory vascular disorder that predominantly affects children and is the leading cause of acquired heart disease in children. Although the etiology of this disease remains unclear, genome-wide association and genome-wide linkage studies have shown that some susceptible genes and chromosomal regions are associated with the development and progression of KD. With the advancement of high-throughput DNA sequencing techniques, more and more genomic information related to KD is being discovered. Understanding the genes involved in the pathogenesis of KD may provide novel insights into the diagnosis and treatment of KD. By analyzing related articles and summarizing related research advances, this article mainly discusses the T cell activation-enhancing genes that have been confirmed to be closely associated with the development and progression of KD and reveals their association with the pathogenesis of KD and coronary artery lesions.
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DONG Ming-Xing
WANG Xi-Xia
JIAO Fu-Yong
ZHANG Wei-Hua
Key wordsKawasaki disease      Genetic polymorphism      Susceptibility      Coronary artery lesion     
Received: 17 August 2023     
Cite this article:   
DONG Ming-Xing,WANG Xi-Xia,JIAO Fu-Yong et al. Research advances in genetic polymorphisms in Kawasaki disease[J]. CJCP, 2023, 25(12): 1234-1238.
DONG Ming-Xing,WANG Xi-Xia,JIAO Fu-Yong et al. Research advances in genetic polymorphisms in Kawasaki disease[J]. CJCP, 2023, 25(12): 1234-1238.
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