基于限制性立方样条模型分析青少年三酰甘油-葡萄糖指数及其衍生指数与血压异常的关系

doi:10.7499/j.issn.1008-8830.2306049

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Abstract Objective To explore the relationship of triglyceride-glucose index (TyG), triglyceride-glucose-body mass index (TyG-BMI), and triglyceride-glucose-waist circumference index (TyG-WC) with blood pressure abnormalities in adolescents, providing theoretical basis for the prevention and control of hypertension in adolescents. Methods A stratified cluster sampling method was used to select 1 572 adolescents aged 12 to 18 years in Yinchuan City for questionnaire surveys, physical measurements, and laboratory tests. Logistic regression analysis and restricted cubic spline analysis were employed to examine the relationship of TyG, TyG-BMI, and TyG-WC with blood pressure abnormalities in adolescents. Results Multivariable logistic regression analysis revealed that after adjusting for confounding factors, the groups with the highest quartile of TyG, TyG-BMI, and TyG-WC had 1.48 times (95%CI: 1.07-2.04), 3.71 times (95%CI: 2.67-5.15), and 4.07 times (95%CI: 2.89-5.73) higher risks of blood pressure abnormalities compared to the groups with the lowest quartile, respectively. Moreover, as the levels of TyG, TyG-BMI, and TyG-WC increased, the risk of blood pressure abnormalities gradually increased (P<0.05). A non-linear dose-response relationship was observed between TyG-BMI and the risk of blood pressure abnormalities (Poverall trend<0.001, Pnon-linearity=0.002). Linear dose-response relationships were found between TyG and the risk of blood pressure abnormalities (Poverall trend<0.001, Pnon-linearit =0.232), and between TyG-WC and the risk of blood pressure abnormalities (Poverall trend<0.001, Pnon-linearity=0.224). Conclusions Higher levels of TyG and its derivatives are associated with an increased risk of blood pressure abnormalities in adolescents, with linear or non-linear dose-response relationships.

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	TIAN Mei
	MA Xiao-Yan
	TONG Ling-Ling
	JIA Lei-Na
	DING Wen-Qing

Key words： Triglyceride-glucose index Triglyceride-glucose-body mass index Triglyceride-glucose-waist circumference index Blood pressure Adolescent

Received: 12 June 2023

Cite this article:

TIAN Mei,MA Xiao-Yan,TONG Ling-Ling et al. Relationship of triglyceride-glucose index and its derivatives with blood pressure abnormalities in adolescents: an analysis based on a restricted cubic spline model[J]. CJCP, 2024, 26(1): 54-61.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2306049 OR http://www.zgddek.com/EN/Y2024/V26/I1/54

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