Research progress on the manifestations and prognosis of neonatal lupus erythematosus in various systems
SHAO Shu-Ming, ZHANG Yi-Min, ZHANG Xiao-Rui
Department of Pediatrics, Peking University People's Hospital, Beijing 100044, China (Zhang X-R, Email: icy.zhang@163.com)
Abstract Neonatal lupus erythematosus (NLE) is caused by the transmission of maternal anti-Ro/SSA antibodies, anti-La/SSB antibodies, and other autoantibodies to the fetus through the placenta. Usually, with the disappearance of autoantibodies in the children's body, abnormal changes in the mucocutaneous, blood system, and digestive system can spontaneously subside, but the damage to various systems caused by autoantibodies may persist for a long time. This article provides a comprehensive review of the manifestations and prognosis of NLE in various systems, including mucocutaneous, blood system, circulatory system, nervous system, digestive system, respiratory system, aiming to provide reference for clinical work.
Key words ：
Neonatal lupus erythematosus
Clinical manifestation
Prognosis
Received: 26 June 2023
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