Urinary protein and renal pathological features in children with immunoglobulin A vasculitis with nephritis and hypercoagulability
BAI Meng-Ke, YANG Xiao-Qing, MEI Xiao-Feng, LI Jin-Gang, YANG Yue-Li, HUANG Yan-Jie
Pediatrics Hospital, First Affiliated Hospital of Henan University of Chinese Medicine/College of Pediatrics, Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China (Huang Y-J, Email: huangyanjie69@163.com)
Abstract Objective To study the association of hypercoagulability with urinary protein and renal pathological damage in children with immunoglobulin A vasculitis with nephritis (IgAVN). Methods Based on the results of coagulation function, 349 children with IgAVN were divided into a hypercoagulability group consisting of 52 children and a non-hypercoagulability group consisting of 297 children. Urinary protein and renal pathological features were compared between the two groups, and the factors influencing the formation of hypercoagulability in children with IgAVN were analyzed. Results Compared with the non-hypercoagulability group, the hypercoagulability group had significantly higher levels of urinary erythrocyte count, 24-hour urinary protein, urinary protein/creatinine, urinary immunoglobulin G/creatinine, and urinary N-acetyl-β-D-glucosaminidase (P<0.05). The hypercoagulability group also had a significantly higher proportion of children with a renal pathological grade of III-IV, diffuse mesangial proliferation, capillary endothelial cell proliferation, or >25% crescent formation (P<0.05). The multivariate logistic regression analysis showed that capillary endothelial cell proliferation and glomerular crescent formation >25% were associated with the formation of hypercoagulability in children with IgAVN (P<0.05). Conclusions The renal injury in IgAVN children with hypercoagulability is more severe, with greater than 25% crescent formation and increased proliferation of glomerular endothelial cells being important contributing factors that exacerbate the hypercoagulable state in IgAVN.
BAI Meng-Ke,YANG Xiao-Qing,MEI Xiao-Feng et al. Urinary protein and renal pathological features in children with immunoglobulin A vasculitis with nephritis and hypercoagulability[J]. CJCP, 2024, 26(2): 164-168.
BAI Meng-Ke,YANG Xiao-Qing,MEI Xiao-Feng et al. Urinary protein and renal pathological features in children with immunoglobulin A vasculitis with nephritis and hypercoagulability[J]. CJCP, 2024, 26(2): 164-168.
WANG Cai-Yun, XU Hong-Mei, LIU Gang, LIU Jing, YU Hui, CHEN Bi-Quan, ZHENG Guo, SHU Min, DU Li-Jun, XU Zhi-Wei, HUANG Li-Su, LI Hai-Bo, WANG Dong, BAI Song-Ting, SHAN Qing-Wen, ZHU Chun-Hui, TIAN Jian-Mei, HAO Jian-Hua, LIN Ai-Wei, LIN Dao-Jiong, WU Jin-Zhun, ZHANG Xin-Hua, CAO Qing, TAO Zhong-Bin, CHEN Yuan, ZHU Guo-Long, XUE Ping, TANG Zheng-Zhen, SU Xue-Wen, QU Zheng-Hai, ZHAO Shi-Yong, PANG Lin, DENG Hui-Ling, SHU Sai-Nan, CHEN Ying-Hu. A multi-center epidemiological study on pneumococcal meningitis in children from 2019 to 2020[J]. CJCP, 2024, 26(2): 131-138.
Branch of Pediatric Critical Care Physicians, Chinese Medical Association; Neonatologists Branch of Chinese Medical Association; Gansu Provincial Maternal and Child Health Hospital/Gansu Provincial Central Hospital/Gansu Pediatric Clinical Medical Research Center; Center for Evidence-Based Medicine, School of Basic Medicine, Lanzhou University/WHO Guidelines for Practice and Knowledge Transformation Cooperation Center/Gansu Province Medical Guideline Technology Center. Clinical practice guidelines for bronchoalveolar lavage in Chinese children (2024)[J]. CJCP, 2024, 26(1): 1-13.
