高海拔地区健康足月新生儿脑氧代谢及脑电活动差异的多中心临床研究方案

doi:10.7499/j.issn.1008-8830.2310102

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Abstract Further evidence is needed to explore the impact of high-altitude environments on the neurologic function of neonates. Non-invasive techniques such as cerebral near-infrared spectroscopy and amplitude-integrated electroencephalography can provide data on cerebral oxygenation and brain electrical activity. This study will conduct multiple cerebral near-infrared spectroscopy and amplitude-integrated electroencephalography monitoring sessions at various time points within the first 3 days postpartum for healthy full-term neonates at different altitudes. The obtained data on cerebral oxygenation and brain electrical activity will be compared between different altitudes, and corresponding reference ranges will be established. The study involves 6 participating centers in the Chinese High Altitude Neonatal Medicine Alliance, with altitude gradients divided into 4 categories: 800 m, 1 900 m, 2 400 m, and 3 500 m, with an anticipated sample size of 170 neonates per altitude gradient. This multicenter prospective cohort study aims to provide evidence supporting the impact of high-altitude environments on early brain function and metabolism in neonates.

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	Articles by authors
	ZE Bi
	GAO Jin
	ZHAO Xiao-Fen
	LI Yang-Fang
	ZHANG Tie-Song
	LIU Xiao-Mei
	MAO Hui
	QIN Ming-Cai
	ZHANG Yi
	YANG Yong-Li
	HE Chun-Ye
	ZHAO Yan
	DU Kun
	LIU Lin
	ZHOU Wen-Hao

Key words： Near-infrared spectroscopy Cerebral oxygenation Amplitude-integrated electroencephalography High altitude Neonate

Received: 23 October 2023

Corresponding Authors: Du K, Email: dukun@etyy.cn E-mail: dukun@etyy.cn

Cite this article:

ZE Bi,GAO Jin,ZHAO Xiao-Fen et al. Cerebral oxygen metabolism and brain electrical activity of healthy full-term neonates in high-altitude areas: a multicenter clinical research protocol[J]. CJCP, 2024, 26(4): 403-409.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2310102 OR http://www.zgddek.com/EN/Y2024/V26/I4/403

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