孟德尔随机化研究在孤独症谱系障碍中的研究进展

doi:10.7499/j.issn.1008-8830.2311030

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Abstract Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder with onset in infancy or early childhood. Mendelian randomization (MR) is a statistical method used to infer causal relationships between exposures and outcomes. This article summarizes MR studies related to ASD. Existing research supports a causal relationship between maternal inflammatory bowel disease in children with ASD, parental education levels, screen time exposure, obesity, insomnia, serum transferrin, decreased blood selenium, abnormal signals in brain functional MRI, interleukin-6, phosphodiesterase 2A, mitogen-activated protein kinase kinase 3, mitochondrial ribosomal protein L33, serotonin, and ASD. However, it does not support a causal relationship between parental rheumatoid arthritis, systemic lupus erythematosus, neonatal jaundice in children with ASD, cytomegalovirus infection, asthma, oral ulcers, vitamin D levels, and ASD. This article reviews the etiological factors related to ASD and MR studies, aiming to explore and deepen the understanding of the pathophysiology of ASD. It provides strong statistical support for the prevention, diagnosis, and treatment of ASD, and offers new methods and strategies for the etiological analysis of complex traits.

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	Articles by authors
	HU Yun-Yang
	TIAN Geng-Chang
	LIU Meng
	WANG Hong

Key words： Autism spectrum disorder Mendelian randomization Research advance Child

Received: 07 November 2023

Cite this article:

HU Yun-Yang,TIAN Geng-Chang,LIU Meng et al. Advances in Mendelian randomization studies on autism spectrum disorder[J]. CJCP, 2024, 26(5): 535-540.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2311030 OR http://www.zgddek.com/EN/Y2024/V26/I5/535

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