儿童原发性十二指肠胃反流与幽门螺杆菌感染对胃炎和抗生素耐药性的影响

doi:10.7499/j.issn.1008-8830.2311086

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Abstract Objective To investigate the risk factors for Helicobacter pylori (HP) infection in children with primary duodenogastric reflux (DGR) and its impact on gastritis and antibiotic resistance. Methods A retrospective analysis was performed on the clinical data of 2 190 children who underwent upper gastrointestinal endoscopy in Wuxi Children's Hospital from January 2019 to February 2022, among whom 308 children were diagnosed with primary DGR. According to the presence or absence of HP infection, the children were classified to HP infection group (53 children) and non-HP infection group (255 children). The risk factors for HP infection and its impact on the incidence rate and severity of gastritis were analyzed. According to the presence or absence of primary DGR, 331 children with HP infection were classified to primary DGR group (29 children) and non-primary DGR group (302 children), and then the impact of primary DGR with HP infection on antibiotic resistance was analyzed. Results The HP infection group had a significantly higher age than the non-HP infection group (P<0.05), and there was a significant difference in the age distribution between the two groups (P<0.05), while there were no significant differences in the incidence rate and severity of gastritis between the two groups (P>0.05). The multivariate logistic regression analysis showed that older age was a risk factor for HP infection in children with DGR (P<0.05). Drug sensitivity test showed that there were no significant differences in the single and combined resistance rates of metronidazole, clarithromycin, and levofloxacin between the primary DGR group and the non-primary DGR group (P>0.05). Conclusions Older age is closely associated with HP infection in children with DGR. Primary DGR with HP infection has no significant impact on gastritis and antibiotic resistance in children.

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	WANG Xu-Yang
	LIN Qiong

Key words： Primary duodenogastric reflux Gastritis Helicobacter pylori Drug resistance Child

Received: 17 November 2023

Cite this article:

WANG Xu-Yang,LIN Qiong. Impact of primary duodenogastric reflux and Helicobacter pylori infection on gastritis and antibiotic resistance in children[J]. CJCP, 2024, 26(5): 493-498.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2311086 OR http://www.zgddek.com/EN/Y2024/V26/I5/493

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