俯卧位在新生儿呼吸窘迫综合征有创呼吸支持中的临床研究

doi:10.7499/j.issn.1008-8830.2312126

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Abstract Objective To assess the effectiveness and safety of prone positioning in the treatment of neonatal respiratory distress syndrome (NRDS) using invasive respiratory support. Methods A prospective study was conducted from June 2020 to September 2023 at Suining County People's Hospital, involving 77 preterm infants with gestational ages less than 35 weeks requiring invasive respiratory support for NRDS. The infants were randomly divided into a supine group (37 infants) and a prone group (40 infants). Infants in the prone group were ventilated in the prone position for 6 hours followed by 2 hours in the supine position, continuing in this cycle until weaning from the ventilator. The effectiveness and safety of the two approaches were compared. Results At 6 hours after enrollment, the prone group showed lower arterial blood carbon dioxide levels, inspired oxygen concentration, oxygenation index, rates of tracheal intubation bacterial colonization, and Neonatal Pain, Agitation and Sedation Scale scores compared to the supine group (P<0.05). There were no significant differences between the groups in terms of pH, arterial oxygen pressure, positive end-expiratory pressure, duration of mechanical ventilation, accidental extubation, ventilator-associated pneumonia, air leak syndrome, skin pressure sores, feeding intolerance, and grades II-IV intraventricular hemorrhage (P>0.05). Conclusions Compared to supine positioning, prone ventilation effectively improves oxygenation, increases comfort, and reduces tracheal intubation bacterial colonization in neonates requiring mechanical ventilation for NRDS, without significantly increasing adverse reactions.

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	CHAI Feng-Yun
	TONG Shi
	HAN Mei
	HU Xiao
	ZHU Chun-Xue
	GAO Xiang-Yu

Key words： Prone ventilation Mechanical ventilation Neonatal respiratory distress syndrome Neonate

Received: 25 December 2023

Corresponding Authors: Tong S，E-mail：15862185137@163.com E-mail: 15862185137@163.com

Cite this article:

CHAI Feng-Yun,TONG Shi,HAN Mei et al. Clinical study of prone positioning in invasive respiratory support for neonatal respiratory distress syndrome[J]. CJCP, 2024, 26(6): 619-624.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2312126 OR http://www.zgddek.com/EN/Y2024/V26/I6/619

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