《美国肠外肠内营养学会早产儿肠外营养指南（2023）》解读

doi:10.7499/j.issn.1008-8830.2312083

Abstract
Figure/Table
References(41)
Related Citation (15)
Read Tracking
Download Tracking

Download: PDF (605 KB) HTML
Export: BibTeX | EndNote (RIS) Supporting Info

Abstract The "Guidelines for parenteral nutrition in preterm infants: the American Society for parenteral and enteral nutrition" were developed by the American Society for Parenteral and Enteral Nutrition and published in the Journal of Parenteral and Enteral Nutrition in September 2023. The guidelines provide recommendations on 12 key clinical questions regarding parenteral nutrition (PN) for preterm infants. In comparison to similar guidelines, this set offers more detailed perspectives on PN for preterm infants. It presents evidence-based recommendations for the commencement time, nutrient dosage, and composition of PN, considering primary outcomes such as growth and development, as well as secondary outcomes like sepsis, retinopathy of prematurity, parenteral nutrition-related liver disease, and jaundice. This article aims to interpret the guidelines to provide a reference for colleagues in the field.

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHANG Xin-Yu
	HE Yang
	TANG Jun
	YU Jia-Jie
	YING Jun-Jie
	MU De-Zhi

Key words： Parenteral nutrition Guideline Preterm infant

Received: 15 December 2023

Corresponding Authors: Tang J，E-mail：tj1234753@sina.com E-mail: tj1234753@sina.com

Cite this article:

ZHANG Xin-Yu,HE Yang,TANG Jun et al. Interpretation of the 2023 "Guidelines for parenteral nutrition in preterm infants: the American Society for Parenteral and Enteral Nutrition"[J]. CJCP, 2024, 26(8): 795-802.

URL:

http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2312083 OR http://www.zgddek.com/EN/Y2024/V26/I8/795

	Moon K, Mckinnon E, Patole S, et al. Current parenteral nutrition practice and clinical outcomes of term and late preterm infants: a retrospective study[J]. Clin Nutr ESPEN, 2023, 55: 178-184. PMID: 37202043. DOI: 10.1016/j.clnesp.2023.03.010.
	中华医学会肠外肠内营养学分会儿科协作组, 中华医学会儿科学分会新生儿学组, 中华医学会小儿外科学分会新生儿学组. 中国新生儿营养支持临床应用指南[J]. 中华儿科杂志, 2006, 44(9): 711-714. PMID: 17217674. DOI: 10.3760/j.issn:0578-1310.2006.09.023.
	3 中华医学会肠外肠内营养学分会儿科学组, 中华医学会儿科学分会新生儿学组, 中华医学会小儿外科学分会新生儿外科学组, 等. 中国新生儿营养支持临床应用指南[J]. 中华小儿外科杂志, 2013, 34(10): 782-787. DOI: 10.3760/cma.j.issn.0253-3006.2013.10.016.
	4 NICE. Neonatal parenteral nutrition[EB/OL]. (2020-02-26)[2023-11-15]. https://www.nice.org.uk/guidance/NG154.
	Robinson DT, Calkins KL, Chen Y, et al. Guidelines for parenteral nutrition in preterm infants: the American Society for Parenteral and Enteral Nutrition[J]. JPEN J Parenter Enteral Nutr, 2023, 47(7): 830-858. PMID: 37610837. DOI: 10.1002/jpen.2550.
	6 周奇, 邢丹, 李沁原, 等. 指南解读类文献报告规范的制订指南（RIGHT for INT）[J]. 中国循证医学杂志, 2022, 22(5): 497-507. DOI: 10.7507/1672-2531.202201137.
	Schünemann HJ, Brennan S, Akl EA, et al. The development methods of official GRADE articles and requirements for claiming the use of GRADE: a statement by the GRADE guidance group[J]. J Clin Epidemiol, 2023, 159: 79-84. PMID: 37211327. DOI: 10.1016/j.jclinepi.2023.05.010.
	Heimler R, Bamberger JM, Sasidharan P. The effects of early parenteral amino acids on sick premature infants[J]. Indian J Pediatr, 2010, 77(12): 1395-1399. PMID: 20830534. DOI: 10.1007/s12098-010-0187-x.
	te Braake FW, van den Akker CH, Wattimena DJ, et al. Amino acid administration to premature infants directly after birth[J]. J Pediatr, 2005, 147(4): 457-461. PMID: 16227030. DOI: 10.1016/j.jpeds.2005.05.038.
	Dongming L, Fengran Z, Zhaojun Z. The study of early intravenous nutrition therapy in very low birth weight infants[J]. Pak J Pharm Sci, 2016, 29(6 Suppl): 2293-2295. PMID: 28167468.
	Balakrishnan M, Jennings A, Przystac L, et al. Growth and neurodevelopmental outcomes of early, high-dose parenteral amino acid intake in very low birth weight infants: a randomized controlled trial[J]. JPEN J Parenter Enteral Nutr, 2018, 42(3): 597-606. PMID: 29187120. DOI: 10.1177/0148607117696330.
	Bellagamba MP, Carmenati E, D'Ascenzo R, et al. One extra gram of protein to preterm infants from birth to 1800 g: a single-blinded randomized clinical trial[J]. J Pediatr Gastroenterol Nutr, 2016, 62(6): 879-884. PMID: 26418211. DOI: 10.1097/MPG.0000000000000989.
	Bloomfield FH, Jiang Y, Harding JE, et al. Early amino acids in extremely preterm infants and neurodisability at 2 years[J]. N Engl J Med, 2022, 387(18): 1661-1672. PMID: 36322845. DOI: 10.1056/NEJMoa2204886.
	Burattini I, Bellagamba MP, Spagnoli C, et al. Targeting 2.5 versus 4 g/kg/day of amino acids for extremely low birth weight infants: a randomized clinical trial[J]. J Pediatr, 2013, 163(5): 1278-1282.e1. PMID: 23941670. DOI: 10.1016/j.jpeds.2013.06.075.
	Li Y, Sun Z, Hu Y, et al. Early administration of amino acids with different doses in low birth weight premature infants[J]. J Res Med Sci, 2020, 25: 49. PMID: 32765619. PMCID: PMC7377119. DOI: 10.4103/jrms.JRMS_213_19.
	Balasubramanian H, Nanavati RN, Kabra NS. Effect of two different doses of parenteral amino acid supplementation on postnatal growth of very low birth weight neonates, a randomized controlled trial[J]. Indian Pediatr, 2013, 50(12): 1131-1136. PMID: 23999674. DOI: 10.1007/s13312-013-0307-6.
	Scattolin S, Gaio P, Betto M, et al. Parenteral amino acid intakes: possible influences of higher intakes on growth and bone status in preterm infants[J]. J Perinatol, 2013, 33(1): 33-39. PMID: 22517036. DOI: 10.1038/jp.2012.44.
	Str?mmen K, Haag A, Moltu SJ, et al. Enhanced nutrient supply to very low birth weight infants is associated with higher blood amino acid concentrations and improved growth[J]. Clin Nutr ESPEN, 2017, 18: 16-22. PMID: 29132733. DOI: 10.1016/j.clnesp.2017.01.003.
	Tan MJ, Cooke RW. Improving head growth in very preterm infants—a randomised controlled trial I: neonatal outcomes[J]. Arch Dis Child Fetal Neonatal Ed, 2008, 93(5): F337-F341. PMID: 18252814. DOI: 10.1136/adc.2007.124230.
	Moltu SJ, Str?mmen K, Blakstad EW, et al. Enhanced feeding in very-low-birth-weight infants may cause electrolyte disturbances and septicemia: a randomized, controlled trial[J]. Clin Nutr, 2013, 32(2): 207-212. PMID: 23043722. DOI: 10.1016/j.clnu.2012.09.004.
	D'Ascenzo R, Savini S, Biagetti C, et al. Higher docosahexaenoic acid, lower arachidonic acid and reduced lipid tolerance with high doses of a lipid emulsion containing 15% fish oil: a randomized clinical trial[J]. Clin Nutr, 2014, 33(6): 1002-1009. PMID: 24525115. DOI: 10.1016/j.clnu.2014.01.009.
	Blanco CL, Gong AK, Schoolfield J, et al. Impact of early and high amino acid supplementation on ELBW infants at 2 years[J]. J Pediatr Gastroenterol Nutr, 2012, 54(5): 601-607. PMID: 22228000. DOI: 10.1097/MPG.0b013e31824887a0.
	Morris EE, Miller NC, Marka NA, et al. Randomized trial of early enhanced parenteral nutrition and later neurodevelopment in preterm infants[J]. Nutrients, 2022, 14(19): 3890. PMID: 36235546. PMCID: PMC9570539. DOI: 10.3390/nu14193890.
	Alburaki W, Yusuf K, Dobry J, et al. High early parenteral lipid in very preterm infants: a randomized-controlled trial[J]. J Pediatr, 2021, 228: 16-23.e1. PMID: 32798567. DOI: 10.1016/j.jpeds.2020.08.024.
	Drenckpohl D, McConnell C, Gaffney S, et al. Randomized trial of very low birth weight infants receiving higher rates of infusion of intravenous fat emulsions during the first week of life[J]. Pediatrics, 2008, 122(4): 743-751. PMID: 18829797. DOI: 10.1542/peds.2007-2282.
	Can E, Bülbül A, Uslu S, et al. Effects of aggressive parenteral nutrition on growth and clinical outcome in preterm infants[J]. Pediatr Int, 2012, 54(6): 869-874. PMID: 22882288. DOI: 10.1111/j.1442-200X.2012.03713.x.
	Morgan C, McGowan P, Herwitker S, et al. Postnatal head growth in preterm infants: a randomized controlled parenteral nutrition study[J]. Pediatrics, 2014, 133(1): e120-e128. PMID: 24379229. DOI: 10.1542/peds.2013-2207.
	Tagare A, Walawalkar M, Vaidya U. Aggressive parenteral nutrition in sick very low birth weight babies: a randomized controlled trial[J]. Indian Pediatr, 2013, 50(10): 954-956. PMID: 23798635. DOI: 10.1007/s13312-013-0258-y.
	Vlaardingerbroek H, Vermeulen MJ, Rook D, et al. Safety and efficacy of early parenteral lipid and high-dose amino acid administration to very low birth weight infants[J]. J Pediatr, 2013, 163(3): 638-644.e5. PMID: 23660378. DOI: 10.1016/j.jpeds.2013.03.059.
	Costa S, Cocca C, Barone G, et al. Growth of head circumference and body length in preterm infants receiving a multicomponent vs a soybean-based lipid emulsion: a randomized controlled trial[J]. JPEN J Parenter Enteral Nutr, 2021, 45(1): 94-101. PMID: 33211326. DOI: 10.1002/jpen.1968.
	Levit OL, Calkins KL, Gibson LC, et al. Low-dose intravenous soybean oil emulsion for prevention of cholestasis in preterm neonates[J]. JPEN J Parenter Enteral Nutr, 2016, 40(3): 374-382. PMID: 24963025. PMCID: PMC4537394. DOI: 10.1177/0148607114540005.
	Kapoor V, Malviya MN, Soll R. Lipid emulsions for parenterally fed term and late preterm infants[J]. Cochrane Database Syst Rev, 2019, 6(6): CD013171. PMID: 31158920. PMCID: PMC6953354. DOI: 10.1002/14651858.CD013171.pub2.
	Alsweiler JM, Harding JE, Bloomfield FH. Tight glycemic control with insulin in hyperglycemic preterm babies: a randomized controlled trial[J]. Pediatrics, 2012, 129(4): 639-647. PMID: 22430450. DOI: 10.1542/peds.2011-2470.
	Arsenault D, Brenn M, Kim S, et al. A.S.P.E.N. clinical guidelines: hyperglycemia and hypoglycemia in the neonate receiving parenteral nutrition[J]. JPEN J Parenter Enteral Nutr, 2012, 36(1): 81-95. PMID: 22179520. DOI: 10.1177/0148607111418980.
	Chen Y, Yang K, Maru?ic A, et al. A reporting tool for practice guidelines in health care: the RIGHT statement[J]. Ann Intern Med, 2017, 166(2): 128-132. PMID: 27893062. DOI: 10.7326/M16-1565.
	Türky?lmaz C, Bilgen H, Kültürsay N. Turkish Neonatal Society guideline on parenteral nutrition in preterm infants[J]. Turk Pediatri Ars, 2018, 53(Suppl 1): S119-S127. PMID: 31236025. PMCID: PMC6568298. DOI: 10.5152/TurkPediatriArs.2018.01812.
	Mihatsch WA, Braegger C, Bronsky J, et al. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition[J]. Clin Nutr, 2018, 37(6 Pt B): 2303-2305. PMID: 30471662. DOI: 10.1016/j.clnu.2018.05.029.
	38 ASPEN. Appropriate dosing for parenteral nutrition: ASPEN recommendations[EB/OL]. (2020-11-17)[2023-11-15]. https://www.nutritioncare.org/uploadedFiles/Documents/Guidelines_and_Clinical_Resources/PN%20Dosing%201-Sheet-Nov%202020-FINAL.pdf.
	Bolisetty S, Osborn D, Schindler T, et al. Standardised neonatal parenteral nutrition formulations: Australasian neonatal parenteral nutrition consensus update 2017[J]. BMC Pediatr, 2020, 20(1): 59. PMID: 32035481. PMCID: PMC7007668. DOI: 10.1186/s12887-020-1958-9.
	Zhang ZX, Yang Q, Shen W, et al. Effect of SMOF lipid emulsion on physical growth and extrauterine growth retardation in very preterm infants: insights from a multicenter retrospective cohort study[J]. Nutrition, 2023, 116: 112221. PMID: 37832169. DOI: 10.1016/j.nut.2023.112221.
	Wang YS, Shen W, Yang Q, et al. Analysis of risk factors for parenteral nutrition-associated cholestasis in preterm infants: a multicenter observational study[J]. BMC Pediatr, 2023, 23(1): 250. PMID: 37210514. PMCID: PMC10199576. DOI: 10.1186/s12887-023-04068-0.