新生儿嗜肺军团菌肺炎2例

doi:10.7499/j.issn.1008-8830.2405123

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Abstract Patient 1, a 12-day-old female infant, presented with fever, cough, dyspnea, and elevated infection markers, requiring respiratory support. Metagenomic next-generation sequencing (mNGS) of blood and bronchoalveolar lavage fluid revealed Legionella pneumophila (LP), leading to diagnoses of LP pneumonia and LP sepsis. The patient was treated with erythromycin for 15 days and azithromycin for 5 days, resulting in recovery and discharge. Patient 2, an 11-day-old female infant, presented with dyspnea, fever, elevated infection markers, and multiple organ dysfunction, requiring mechanical ventilation. mNGS of blood and cerebrospinal fluid indicated LP, leading to diagnoses of LP pneumonia, LP sepsis, and LP intracranial infection. The patient was treated with erythromycin for 19 days and was discharged after recovery. Neonatal LP pneumonia lacks specific clinical symptoms, and azithromycin is the preferred antimicrobial agent. The use of mNGS can provide early and definitive diagnosis for severe neonatal pneumonia of unknown origin.

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	Articles by authors
	LIU Yin-Zhi
	ZHANG Rong
	XIE Jing-Jing
	GUO Qiong
	ZHAN Cai-Xia
	CHEN Meng-Yu
	LI Jun-Shuai
	PENG Xiao-Ming

Key words： Pneumonia Legionella Metagenomic next-generation sequencing Neonate

Received: 28 May 2024

Corresponding Authors: liuyinzhi0837@163.com。 E-mail: liuyinzhi0837@163.com

Cite this article:

LIU Yin-Zhi,ZHANG Rong,XIE Jing-Jing et al. Two cases of neonatal Legionella pneumonia[J]. CJCP, 2024, 26(9): 986-988.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2405123 OR http://www.zgddek.com/EN/Y2024/V26/I9/986

	Allgaier J, Lagu T, Haessler S, et al. Risk factors, management, and outcomes of Legionella pneumonia in a large, nationally representative sample[J]. Chest, 2021, 159(5): 1782-1792. PMID: 33352192. DOI: 10.1016/j.chest.2020.12.013.
	Rapaka RR, Cross AS, McArthur MA. Using adjuvants to drive T cell responses for next-generation infectious disease vaccines[J]. Vaccines (Basel), 2021, 9(8): 820. PMID: 34451945. PMCID: PMC8402546. DOI: 10.3390/vaccines9080820.
	Viasus D, Gaia V, Manzur-Barbur C, et al. Legionnaires' disease: update on diagnosis and treatment[J]. Infect Dis Ther, 2022, 11(3): 973-986. PMID: 35505000. PMCID: PMC9124264. DOI: 10.1007/s40121-022-00635-7.
	Perez Ortiz A, Hahn C, Schaible T, et al. Severe pneumonia in neonates associated with Legionella pneumophila: case report and review of the literature[J]. Pathogens, 2021, 10(8): 1031. PMID: 34451495. PMCID: PMC8400773. DOI: 10.3390/pathogens10081031.
	Leruste A, Rambaud J, Picard C, et al. Successful pediatric ECMO in a rare case of septic shock due to a community-acquired Legionella infection[J]. Med Mal Infect, 2017, 47(1): 68-70. PMID: 27810124. DOI: 10.1016/j.medmal.2016.09.006.
	Barton M, McKelvie B, Campigotto A, et al. Legionellosis following water birth in a hot tub in a Canadian neonate[J]. CMAJ, 2017, 189(42): E1311-E1313. PMID: 29061856. PMCID: PMC5654988. DOI: 10.1503/cmaj.170711.
	Bell H, Chintalapati S, Patel P, et al. Legionella longbeachae pneumonia: case report and review of reported cases in non-endemic countries[J]. IDCases, 2021, 23: e01050. PMID: 33511033. PMCID: PMC7817369. DOI: 10.1016/j.idcr.2021.e01050.
	Rothberg MB, Imrey PB, Guo N, et al. A risk model to identify Legionella among patients admitted with community-acquired pneumonia: a retrospective cohort study[J]. J Hosp Med, 2022, 17(8): 624-632. PMID: 35880811. PMCID: PMC9531289. DOI: 10.1002/jhm.12919.
	Eidy H, Senger B, Steele J, et al. An atypical presentation of Legionnaires' disease[J]. Cureus, 2024, 16(5): e60856. PMID: 38910759. PMCID: PMC11192066. DOI: 10.7759/cureus.60856.
	Zhang XL, Zhang X, Hua W, et al. Expert consensus on the diagnosis, treatment, and prevention of respiratory syncytial virus infections in children[J]. World J Pediatr, 2024, 20(1): 11-25. PMID: 38064012. PMCID: PMC10828005. DOI: 10.1007/s12519-023-00777-9.
	Zhang R, Zhuang Y, Xiao ZH, et al. Diagnosis and surveillance of neonatal infections by metagenomic next-generation sequencing[J]. Front Microbiol, 2022, 13: 855988. PMID: 35401464. PMCID: PMC8989347. DOI: 10.3389/fmicb.2022.855988.
	Dunne WM, Picot N, van Belkum A. Laboratory tests for Legionnaire's disease[J]. Infect Dis Clin North Am, 2017, 31(1): 167-178. PMID: 27979684. DOI: 10.1016/j.idc.2016.10.012.
	Griffin AT, Peyrani P, Wiemken T, et al. Macrolides versus quinolones in Legionella pneumonia: results from the community-acquired pneumonia organization international study[J]. Int J Tuberc Lung Dis, 2010, 14(4): 495-499. PMID: 20202309.