Current clinical application of glomerular filtration rate assessment methods in pediatric populations

WANG Zi-Sai; WANG Sheng-Feng; ZHAO Ming-Yi; HE Qing-Nan

doi:10.7499/j.issn.1008-8830.2401011

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Chinese Journal of Contemporary Pediatrics ›› 2024, Vol. 26 ›› Issue (9) : 1002-1008. DOI: 10.7499/j.issn.1008-8830.2401011

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Current clinical application of glomerular filtration rate assessment methods in pediatric populations

WANG Zi-Sai, WANG Sheng-Feng, ZHAO Ming-Yi, HE Qing-Nan

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Abstract

Glomerular filtration rate (GFR) is a critical indicator of renal function assessment, which exhibits age-dependency in children and may differ from adults under various disease conditions. In recent years, there has been a growing focus on GFR among scholars, with an increasing number of clinical studies dedicated to refining and optimizing GFR estimation to span all pediatric age groups. However, the methods and assessment equations for estimating GFR may vary under different disease conditions, affecting the accuracy and applicability of assessments. This article reviews the peculiarities of renal function in children, explores GFR measurement methods, and evaluates the application of various GFR assessment equations in pediatric clinical practice, providing a reference for clinical assessment of renal function in children.

Key words

Glomerular filtration rate / Creatinine / Cystatin C / Renal function assessment / Child

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WANG Zi-Sai, WANG Sheng-Feng, ZHAO Ming-Yi, HE Qing-Nan. Current clinical application of glomerular filtration rate assessment methods in pediatric populations[J]. Chinese Journal of Contemporary Pediatrics. 2024, 26(9): 1002-1008 https://doi.org/10.7499/j.issn.1008-8830.2401011

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