儿童急性红白血病临床特点及预后分析

doi:10.7499/j.issn.1008-8830.2405138

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Abstract Objective To investigate the clinical characteristics and prognosis of acute erythroleukemia (AEL) in children. Methods A retrospective analysis was conducted on the clinical data, treatment, and prognosis of 8 children with AEL treated at the First Affiliated Hospital of Zhengzhou University from January 2013 to December 2023. Results Among the 7 patients with complete bone marrow morphological analysis, 4 exhibited trilineage dysplasia, with a 100% incidence of erythroid dysplasia (7/7), a 71% incidence of myeloid dysplasia (5/7), and a 57% incidence of megakaryocytic dysplasia (4/7). Immunophenotyping revealed that myeloid antigens were primarily expressed as CD13, CD33, CD117, CD38, and CD123, with 4 cases expressing erythroid antigens CD71 and 2 cases expressing CD235a. Chromosomal analysis indicated that 2 cases presented with abnormal karyotypes, including +8 in one case and +4 accompanied by +6 in another; no complex karyotypes were observed. Genetic abnormalities were detected in 4 cases, with fusion genes including one case each of dup MLL positive and EVI1 positive, as well as mutations involving KRAS, NRAS, WT1, and UBTF. Seven patients received chemotherapy, with 6 achieving remission after one course of treatment; 2 underwent hematopoietic stem cell transplantation, and all had disease-free survival. Follow-up (median follow-up time of 6 months) showed that only 3 patients survived (2 cases after hematopoietic stem cell transplantation and 1 case during treatment). Conclusions Children with AEL have unique clinical and biological characteristics, exhibit poor treatment response, and have a poor prognosis; however, hematopoietic stem cell transplantation may improve overall survival rates.

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	ZHU Ping
	QI Wen-Jing
	TAO Ye-Qing
	CUI Ding-Ding
	SHENG Guang-Yao
	WANG Chun-Mei

Key words： Acute erythroleukemia Clinical characteristic Prognosis Child

Received: 31 May 2024

Corresponding Authors: Wang C-M,meichun123@126.com。 E-mail: meichun123@126.com

Cite this article:

ZHU Ping,QI Wen-Jing,TAO Ye-Qing et al. Clinical characteristics and prognosis of acute erythroleukemia in children[J]. CJCP, 2025, 27(1): 88-93.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2405138 OR http://www.zgddek.com/EN/Y2025/V27/I1/88

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