Abstract OBJECTIVE: Selenium is an essential trace element and has a main role in cellular antioxidant defense system. In very preterm babies, low selenium is associated with an increased risk of complications such as chronic neonatal lung disease and retinopathy of prematurity. This study was designed to determine and compare maternal and umbilical cord blood selenium levels in term and preterm infants. METHODS: From February 2008 to April 2008, 30 term (gestational age >37 weeks) and 30 preterm infants (gestational age<34 weeks) and their mothers were enrolled. Selenium concentrations in umbilical cord and maternal venous blood were measured by atomic absorption spectrometry. RESULTS: The mean selenium concentration in term infants was higher than in preterm infants (124.80±13.72 μg/L vs 100.30±11.72 μg/L, P=0.0001). The mean selenium concentration in mothers of term and preterm infants was not significantly different (117.03±17.15 μg/L vs 110.56±17.49 μg/L, P=0.15). Cord selenium concentrations were strongly correlated with gestational age and birth weight (r=0.66, P<0.0001 and r=0.59, P<0.0001, respectively) when the data of all infants were analyzed together. None of the 60 women had a serum selenium level below the laboratory lower limit of normal (70.0 μg/L). Maternal selenium levels were correlated with cord selenium levels in their infants (r=0.40, P<0.001) when data of all newborn infants and mothers were considered together. CONCLUSIONS: Mothers have a relatively good selenium status and serum selenium is not a significant predictor of preterm delivery in Isfahan. The cord selenium concentration in term infants is significantly higher than in preterm infants, but the cord selenium concentrations in both groups are in a suggested normal range.[Chin J Contemp Pediatr, 2009, 11 (7):513-516]
Ramin IRANPOUR,Ali ZANDIAN,Majid MOHAMMADIZADEH et al. Comparison of maternal and umbilical cord blood selenium levels in term and preterm infants[J]. 中国当代儿科杂志, 2009, 11(07): 513-516.
Ramin IRANPOUR,Ali ZANDIAN,Majid MOHAMMADIZADEH et al. Comparison of maternal and umbilical cord blood selenium levels in term and preterm infants[J]. CJCP, 2009, 11(07): 513-516.
[1]Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, et al. Characterization of mammalian selenoproteomes[J]. Science, 2003, 300(5624):1439-1443.
[2]Arthur JR, Beckett GJ. New metabolic roles for selenium[J]. Proc Nutr Soc, 1994, 53(3):615-624.
[3]Rayman MP. The importance of selenium to human health[J]. Lancet, 2000, 356(9225):233-241.
[4]Keshan Disease Research Group. Observations on effect of sodium selenite in prevention of Keshan disease[J]. Chin Med J, 1979, 92(7):471-476.
[5]Thomson CD, Robinson MF. Selenium in human health and disease with emphasis on those aspects peculiar to New Zealand[J]. Am J Clin Nutr, 1980, 33(2):303-323.
[6]Lahermo P, Alfthan G, Wang D. Selenium and arsenic in the environment in Finland[J]. J Environ Pathol Toxicol Oncol, 1998, 17(3-4):205-216.
[7]Liu Y, Chiba M, Inaba Y, Kondo M. Keshan disease—a review from the aspect of history and etiology[J]. Nippon Eiseigaku Zasshi, 2002, 56(4):641-648.
[8]Trindade CE. Minerals in the nutrition of extremely low birth weight infants[J]. J Pediatr (Rio J), 2005, 81(1 Suppl):S43-S51.
[9]Gathwala G, Yadav OP. Selenium in the neonate[J]. Indian J Pediatr, 2002, 69(5):443-446.
[10]Makhoul IR, Sammour RN, Diamond E, Shohat I, Tamir A, Shamir R. Selenium concentrations in maternal and umbilical cord blood at 24-42 weeks of gestation: basis for optimization of selenium supplementation to premature infants[J]. Clin Nutr, 2004, 23(3):373-381.
[11]Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids[M]. Washington, DC: National Academy Press, 2000, 284-324, 428-429, 446-447.
[12]Gathwala G, Yadav OP, Sangwan K, Singh I, Yadav J. A study on plasma selenium level among pregnant women at Rohtak, Haryana[J]. Indian J Public Health, 2003, 47(2):45-48.
[13]Dobrzynski W, Trafikowska U, Trafikowska A, Pilicki A, Szymanski W, Zachara BA. Decreased selenium concentration in maternal and cord blood in preterm compared with term delivery[J]. Analyst, 1998, 123(1):93-97.
[14]Litov RE, Comb SGP. Selenium in pediatric nutrition[J]. Pediatrics, 1991, 87(3):339-351.
[15]Bogden JD, Kemp FW, Chen X, Stangnaro-Green A, Stein TP,Scholl TO. Low-normal serum selenium early in human pregnancy predicts lower birthweight[J]. Nutr Res, 2006, 26(10):497-502.
[16]Ozdemir HS, Karadas F, Pappas AC, Cassey P, Oto G, Tuncer O. The selenium levels of mothers and their neonates using hair, breast milk, meconium, and maternal and umbilical cord blood in Van Basin[J]. Biol Trace Elem Res, 2008,122(3):206-215.
[17]Kurtoglu S, Akcakus M, Gunes T, Muhtaroglu S, Kocaoglu C, Poyrazoglu H. Selenium content in maternal and umbilical cord blood in Kayseri province[J]. Cocuk Sagligi Hastalik Derg, 2002, 45(2):130-134.
[18]Micetic-Turk D, Rossipal E, Krachler M, Li F. Maternal selenium status in Slovenia and its impact on the selenium concentration of umbilical cord serum and colostrum[J]. Eur J Clin Nutr, 2000, 54(6):522-524.
[19]Lorenzo-Alonso MJ, Bermejo-Barrera A, Cocho de Juan JA, Fraga Bermudez JM, Bermejo-Barrera P. Selenium levels in related biological samples: human placenta, maternal and umbilical cord blood, hair and nails[J]. J Trace Elem Med Biol, 2005, 19(1):49-54.