PDF(1566 KB)
PDF(1566 KB)
PDF(1566 KB)
儿童良性癫痫伴中央颞区棘波认知障碍的多模态磁共振研究进展
Research advances in multimodal magnetic resonance for cognitive impairment in children with benign childhood epilepsy with centrotemporal spikes
儿童良性癫痫伴中央颞区棘波（BECT）患儿的认知障碍病因复杂，与异常的神经网络密切相关。脑结构和脑功能的多模态磁共振影像技术是研究癫痫认知障碍异常神经网络的强有力工具，可通过分析脑结构和脑功能相关的影像学特征，探索癫痫认知障碍的发生机制。该文就BECT患儿认知障碍在多模态磁共振方面的研究进展进行综述。
Cognitive impairment in children with benign childhood epilepsy with centrotemporal spikes (BECT) has complex etiologies and is closely associated abnormal neural networks. Multimodal magnetic resonance imaging of brain structure and function is a powerful tool for studying abnormal neural networks of cognitive impairment in epilepsy and can explore the pathogenesis of cognitive impairment in epilepsy at the level of brain structure and function by analyzing the imaging features of brain structure and function. This article reviews the research advances in multimodal magnetic resonance for cognitive impairment in children with BECT.
儿童良性癫痫伴中央颞区棘波 / 认知障碍 / 多模态磁共振 / 儿童
Benign childhood epilepsy with centrotemporal spikes / Cognitive impairment / Multimodal magnetic resonance imaging / Child
[1] 刘晓燕. 临床脑电图学[M]. 北京:人民卫生出版社, 2006:326-327.
[2] Ma Y, Chen G, Wang Y, et al. Language dysfunction is associated with age of onset of benign epilepsy with centrotemporal spikes in children[J]. Eur Neurol, 2015, 73(3-4):179-183.
[3] Cheng D, Yan X, Gao Z, et al. Common and distinctive patterns of cognitive dysfunction in children with benign epilepsy syndromes[J]. Pediatr Neurol, 2017, 72:36-41.e1.
[4] Pal DK, Ferrie C, Addis L, et al. Idiopathic focal epilepsies:the "lost tribe"[J]. Epileptic Disord, 2016, 18(3):252-288.
[5] Vannest J, Tenney JR, Altaye M, et al. Impact of frequency and lateralization of interictal discharges on neuropsychological and fine motor status in children with benign epilepsy with centrotemporal spikes[J]. Epilepsia, 2016, 57(8):e161-e167.
[6] Eom S, Lee MK, Park JH, et al. The impact of a 35-week long-term exercise therapy on psychosocial health of children with benign epilepsy[J]. J Child Neurol, 2016, 31(8):985-990.
[7] Lima EM, Rzezak P, Guimarães CA, et al. The executive profile of children with benign epilepsy of childhood with centrotemporal spikes and temporal lobe epilepsy[J]. Epilepsy Behav, 2017, 72:173-177.
[8] Törnhage M, Sandberg EN, Lundberg S. Oromotor, word retrieval, and dichotic listening performance in young adults with previous Rolandic epilepsy[J]. Eur J Paediatr Neurol, 2020, 25:139-144.
[9] 刘啸莳, 陈涛, 张鹏, 等. 认知综合复杂性:评估方法及相关研究[J].心理研究, 2020, 13(1):8-15.
[10] Wilson SJ, Baxendale S, Barr W, et al. Indications and expectations for neuropsychological assessment in routine epilepsy care:report of the ILAE Neuropsychology Task Force, Diagnostic Methods Commission, 2013-2017[J]. Epilepsia, 2015, 56(5):674-681.
[11] Calamia M, Markon K, Tranel D. The robust reliability of neuropsychological measures:meta-analyses of test-retest correlations[J]. Clin Neuropsychol, 2013, 27(7):1077-1105.
[12] Hermann B, Loring DW, Wilson S. Paradigm shifts in the neuropsychology of epilepsy[J]. J Int Neuropsychol Soc, 2017, 23(9-10):791-805.
[13] Baxendale S, Thompson P. Beyond localization:the role of traditional neuropsychological tests in an age of imaging[J]. Epilepsia, 2010, 51(11):2225-2230.
[14] Hur YJ. Guideline for advanced neuroimaging in pediatric epilepsy[J]. Clin Exp Pediatr, 2020, 63(3):100-101.
[15] Whelan CD, Altmann A, Botía JA, et al. Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study[J]. Brain, 2018, 141(2):391-408.
[16] Bao Y, He R, Zeng Q, et al. Investigation of microstructural abnormalities in white and gray matter around hippocampus with diffusion tensor imaging (DTI) in temporal lobe epilepsy (TLE)[J]. Epilepsy Behav, 2018, 83:44-49.
[17] Ashraf-Ganjouei A, Rahmani F, Aarabi MH, et al. White matter correlates of disease duration in patients with temporal lobe epilepsy:updated review of literature[J]. Neurol Sci, 2019, 40(6):1209-1216.
[18] Berg AT, Berkovic SF, Brodie MJ, et al. Revised terminology and concepts for organization of seizures and epilepsies:report of the ILAE Commission on Classification and Terminology, 2005-2009[J]. Epilepsia, 2010, 51(4):676-685.
[19] Tóth K, Hofer KT, Kandrács Á, et al. Hyperexcitability of the network contributes to synchronization processes in the human epileptic neocortex[J]. J Physiol, 2018, 596(2):317-342.
[20] Eixarch E, Muñoz-Moreno E, Bargallo N, et al. Motor and cortico-striatal-thalamic connectivity alterations in intrauterine growth restriction[J]. Am J Obstet Gynecol, 2016, 214(6):725. e1-e9.
[21] Skelin I, Kilianski S, McNaughton BL. Hippocampal coupling with cortical and subcortical structures in the context of memory consolidation[J]. Neurobiol Learn Mem, 2019, 160:21-31.
[22] 胡家玮. 颞叶联合皮层参与听觉和视觉工作记忆的神经机制[D].上海:华东师范大学, 2019.
[23] 张斌,张杰文,张淑玲,等. 正常人汉字工作记忆功能磁共振脑激活区改变的研究[J]. 中国实用神经疾病杂志, 2017, 20(19):5-9.
[24] Rogdaki M, Gudbrandsen M, McCutcheon RA, et al. Magnitude and heterogeneity of brain structural abnormalities in 22q11.2 deletion syndrome:a meta-analysis[J]. Mol Psychiatry, 2020. doi:10.1038/s41380-019-0638-3. Epub ahead of print.
[25] Duret P, Samson F, Pinsard B, et al. Gyrification changes are related to cognitive strengths in autism[J]. Neuroimage Clin, 2018, 20:415-423.
[26] Karalok ZS, Öztürk Z, Gunes A. Cortical thinning in benign epilepsy with centrotemporal spikes (BECTS) with or without attention-deficit/hyperactivity (ADHD)[J]. J Clin Neurosci, 2019, 68:123-127.
[27] Kanemura H, Hata S, Aoyagi K, et al. Serial changes of prefrontal lobe growth in the patients with benign childhood epilepsy with centrotemporal spikes presenting with cognitive impairments/behavioral problems[J]. Brain Dev, 2011, 33(2):106-113.
[28] Garcia-Ramos C, Jackson DC, Lin JJ, et al. Cognition and brain development in children with benign epilepsy with centrotemporal spikes[J]. Epilepsia, 2015, 56(10):1615-1622.
[29] Shakeri M, Datta AN, Malfait D, et al. Sub-cortical brain morphometry and its relationship with cognition in rolandic epilepsy[J]. Epilepsy Res, 2017, 138:39-45.
[30] 杨伟明. 儿童良性癫痫伴中央颞区棘波全脑白质磁共振扩散张量成像研究[D]. 武汉:江汉大学, 2019.
[31] Kim SE, Lee JH, Chung HK, et al. Alterations in white matter microstructures and cognitive dysfunctions in benign childhood epilepsy with centrotemporal spikes[J]. Eur J Neurol, 2014, 21(5):708-717.
[32] Ciumas C, Saignavongs M, Ilski F, et al. White matter development in children with benign childhood epilepsy with centro-temporal spikes[J]. Brain, 2014, 137(Pt 4):1095-1106.
[33] Gauthier CJ, Fan AP. BOLD signal physiology:models and applications[J]. Neuroimage, 2019, 187:116-127.
[34] Raichle ME. The brain's default mode network[J]. Annu Rev Neurosci, 2015, 38:433-447.
[35] Mohan A, Roberto AJ, Mohan A, et al. The significance of the Default Mode Network (DMN) in neurological and neuropsychiatric disorders:a review[J]. Yale J Biol Med, 2016, 89(1):49-57.
[36] Ofer I, Jacobs J, Jaiser N, et al. Cognitive and behavioral comorbidities in Rolandic epilepsy and their relation with default mode network's functional connectivity and organization[J]. Epilepsy Behav, 2018, 78:179-186.
[37] 曲冰倩, 毓青, 燕鑫鑫, 等. 应用基于局部一致性、低频振幅、低频振幅分数的静息态功能磁共振成像对伴中央颞区棘波的儿童良性癫痫认知功能的研究[J]. 癫痫杂志, 2018, 4(6):473-479.
[38] Corbetta M, Shulman GL. Spatial neglect and attention networks[J]. Annu Rev Neurosci, 2011, 34:569-599.
[39] Li R, Ji GJ, Yu Y, et al. Epileptic discharge related functional connectivity within and between networks in benign epilepsy with centrotemporal spikes[J]. Int J Neural Syst, 2017, 27(7):1750018.
[40] Xiao F, Li L, An D, et al. Altered attention networks in benign childhood epilepsy with centrotemporal spikes (BECTS):a resting-state fMRI study[J]. Epilepsy Behav, 2015, 45:234-241.
[41] 燕鑫鑫, 毓青, 郜玉婷, 等. 长程视频脑电结合静息态功能磁共振成像在儿童良性癫痫伴中央颞区棘波患者认知功能检测中的应用[J]. 中华医学杂志, 2017, 97(19):1474-1478.
[42] Chen S, Fang J, An D, et al. The focal alteration and causal connectivity in children with new-onset benign epilepsy with centrotemporal spikes[J]. Sci Rep, 2018, 8(1):5689.
[43] Kim HJ, Lee JH, Park CH, et al. Role of language-related functional connectivity in patients with benign childhood epilepsy with centrotemporal spikes[J]. J Clin Neurol, 2018, 14(1):48-57.
[44] McGinnity CJ, Smith AB, Yaakub SN, et al. Decreased functional connectivity within a language subnetwork in benign epilepsy with centrotemporal spikes[J]. Epilepsia Open, 2017, 2(2):214-225.
[45] Piccirilli M, D'Alessandro P, Tiacci C, et al. Language lateralization in children with benign partial epilepsy[J]. Epilepsia, 1988, 29(1):19-25.
[46] Oser N, Hubacher M, Specht K, et al. Default mode network alterations during language task performance in children with benign epilepsy with centrotemporal spikes (BECTS)[J]. Epilepsy Behav, 2014, 33:12-17.
[47] Malfait D, Tucholka A, Mendizabal S, et al. fMRI brain response during sentence reading comprehension in children with benign epilepsy with centro-temporal spikes[J]. Epilepsy Res, 2015, 117:42-51.
[48] Ciumas C, Laurent A, Saignavongs M, et al. Behavioral and fMRI responses to fearful faces are altered in benign childhood epilepsy with centrotemporal spikes (BCECTS)[J]. Epilepsia, 2017, 58(10):1716-1727.
[49] Alper J. EEG + MRI:a sum greater than the parts[J]. Science, 1993, 261(5121):559.
[50] Lengler U, Kafadar I, Neubauer BA, et al. fMRI correlates of interictal epileptic activity in patients with idiopathic benign focal epilepsy of childhood. A simultaneous EEG-functional MRI study[J]. Epilepsy Res, 2007, 75(1):29-38.
[51] Bear JJ, Chapman KE, Tregellas JR. The epileptic network and cognition:what functional connectivity is teaching us about the childhood epilepsies[J]. Epilepsia, 2019, 60(8):1491-1507.
[52] Xiao F, An D, Lei D, et al. Real-time effects of centrotemporal spikes on cognition in rolandic epilepsy:an EEG-fMRI study[J]. Neurology, 2016, 86(6):544-551.
[53] 马翠花. 认知行为干预对癫痫患儿适应行为及自尊水平的影响[J]. 临床护理杂志, 2019, 18(6):41-43.
