PDF(970 KB)
PDF(970 KB)
PDF(970 KB)
川崎病——儿童COVID-19的一种新的表现形式
Kawasaki disease-a new manifestation of COVID-19 in children
欧美国家发现，2019冠状病毒病（COVID-19）流行以来，川崎病的发生率明显上升，引发儿科医师与家长的担忧。COVID-19会引起全身多个器官出现炎症反应，与川崎病的全身系统血管炎性改变类似，甚至COVID-19也会造成四肢末端的皮肤红疹，这也与川崎病类似。川崎病的病因目前尚不明确，现在也不能除外COVID-19与川崎病的发病率增加有关。因此，在COVID-19流行期间，如果患儿出现类似于川崎病样症状，应尽早使用静脉注射免疫球蛋白治疗，降低冠状动脉损害的发生。
Since the outbreak of coronavirus disease 2019 (COVID-19) in Europe and America, the incidence of Kawasaki disease has significantly increased, which has aroused concern among pediatricians and parents. COVID-19 can cause inflammation reactions of multiple organs, which is similar to the systemic vasculitis of Kawasaki disease, and even COVID-19 can cause skin rash on the extremities of the limbs, which is also similar to Kawasaki disease. The cause of Kawasaki disease is currently unclear, and it cannot be ruled out that COVID-19 is associated with an increased incidence of Kawasaki disease. Therefore, during the epidemic of COVID-19, if children have symptoms similar to Kawasaki disease, intravenous immunoglobulin is recommended as early as possible to reduce the incidence of coronary artery lesions.
[1] 焦富勇. 川崎病[M]. 北京:人民卫生出版社, 2014:14.
[2] Jiao F, Yan X, Wu X. The Xi'an experience of Kawasaki disease-lessons learnt over 5 years[J]. Indian J Pediatr, 2016, 83(10):1195-1196.
[3] Elakabawi K, Lin J, Jiao F, et al. Kawasaki disease:global burden and genetic background[J]. Cardiol Res, 2020, 11(1):9-14.
[4] McCrindle BW, Rowley AH, Newburger JW, et al. Diagnosis, treatment, and long-term management of Kawasaki disease:a scientific statement for health professionals from the American Heart Association[J]. Circulation, 2017, 135(17):e927-e999.
[5] Kuo HC, Li SC, Guo MM, et al. Genome-wide association study identifies novel susceptibility genes associated with coronary artery aneurysm formation in Kawasaki disease[J]. PLoS One, 2016, 11(5):e0154943.
[6] Guo MM, Tseng WN, Ko CH, et al. Th17-and Treg-related cytokine and mRNA expression are associated with acute and resolving Kawasaki disease[J]. Allergy, 2015, 70(3):310-318.
[7] Shi Z, Hu Z. A review of studies on animal reservoirs of the SARS coronavirus[J]. Virus Res, 2008, 133(1):74-87.
[8] Woodyatt A, Howard J. Coronavirus could be tied to a rare but serious illness in children, UK doctors say[EB/OL]. (2020-04-27)[2020-05-16]. https:/edition.cnn.com/2020/04/27/health/children-covid-19-illness-intl-scli-gbr.
[9] Odom John AR. New York announces deaths of children from illness linked to COVID-19[EB/OL]. (2020-05-11)[2020-05-16]. https://www.healio.com/news/pediatrics/20200511/new-york-announces-deaths-of-children-from-illness-linked-to-covid19.
[10] Riphagen S, Gomez X, Gonzalez-Martinez C, et al. Hyperinflammatory shock in children during COVID-19 pandemic[J]. Lancet, 2020, 395(10237):1607-1608.
