培门冬酶治疗儿童白血病研究进展

刘丽; 谢晓恬

doi:10.7499/j.issn.1008-8830.2014.02.012

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中国当代儿科杂志 ›› 2014, Vol. 16 ›› Issue (2) : 155-160. DOI: 10.7499/j.issn.1008-8830.2014.02.012

血液肿瘤专题

培门冬酶治疗儿童白血病研究进展

刘丽, 谢晓恬

作者信息 +

Advances on the role of pegaspargase in the treatment of childhood leukemia

LIU Li, XIE Xiao-Tian

Author information +

文章历史 +

摘要

左旋门冬酰胺酶（L-asparaginase，L-asp）作为治疗急性淋巴细胞白血病（ALL）化疗药物重要组成已超过30 年，可明显改善儿童ALL 的远期疗效。然而，L-asp 的高不良反应发生率促使了培门冬酶（pegaspargase，PEG-asp）的发展，已有大量研究证明，PEG-asp 在保留了L-asp 的抗肿瘤活性的基础上，半衰期较L-asp 明显延长，且存在降低不良反应发生率的潜在优势。该文概述L-asp 的研究与临床应用历史、PEGasp的发展进程，归纳文献资料评估不同种类L-asp 的药理学潜力与临床疗效，以及PEG-asp 临床应用情况与不良反应实际发生率。该文收集了所有网上已发表的、可供分析的PEG-asp 临床资料，希望能为临床提供参考。

Abstract

The chemotherapy agent L-asparaginase (L-asp) has been an important part of acute lymphoblastic leukemia therapy for over 30 years. It is evident that L-asp has a long-term curative effect. However, L-asp is associated with high incidence of adverse reactions. This has prompted the development of pegylated asparaginase (PEG-asp), which has undergone extensive testing. Apparently, PEG-asp has a prolonged half-life with a better tolerance profile while retaining the antileukemic effect. In this review, we attempt to outline the history of clinical application of L-asp, the pharmacological and clinical potential of various preparations of L-asp, the development of PEG-asp, and the clinical application and adverse events of PEG-asp. The literatures reviewed in this article is collected through online search of the major databases both in English and Chinese.

导出引用

刘丽, 谢晓恬. 培门冬酶治疗儿童白血病研究进展[J]. 中国当代儿科杂志. 2014, 16(2): 155-160 https://doi.org/10.7499/j.issn.1008-8830.2014.02.012

LIU Li, XIE Xiao-Tian. Advances on the role of pegaspargase in the treatment of childhood leukemia[J]. Chinese Journal of Contemporary Pediatrics. 2014, 16(2): 155-160 https://doi.org/10.7499/j.issn.1008-8830.2014.02.012

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