注意缺陷多动障碍患儿血清25羟基维生素D水平的检测

上官莉莉; 赵亚茹

doi:10.7499/j.issn.1008-8830.2015.08.015

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中国当代儿科杂志 ›› 2015, Vol. 17 ›› Issue (8) : 837-840. DOI: 10.7499/j.issn.1008-8830.2015.08.015

论著·临床研究

注意缺陷多动障碍患儿血清25羟基维生素D水平的检测

上官莉莉, 赵亚茹

作者信息 +

Serum levels of 25-hydroxyvitamin D in children with attention deficit hyperactivity disorder

SHANG-GUAN Li-Li, ZHAO Ya-Ru

Author information +

文章历史 +

摘要

目的了解注意缺陷多动障碍(ADHD)患儿维生素D的营养状况,探讨维生素D与ADHD的关系。方法选取2014年 1月至2015年 1月符合美国精神障碍诊断与统计手册第五版(DSM-V)中ADHD诊断、分型标准的97例ADHD患儿为病例组,其中注意缺陷为主型(ADHD-I型)46例,多动冲动为主型(ADHD-HI型)10例,混合型(ADHD-C型)41例,以同期同年龄行健康体检儿童97例作为对照组。采用电化学发光法对ADHD组和对照组儿童血清中25羟基维生素D[25(OH)D]水平进行检测,比较两组儿童25(OH)D水平的差异。结果 ADHD组患儿血清25(OH)D水平(17±7 ng/mL)明显低于对照组(23±8 ng/mL)(P< 0.01);且各亚型ADHD患儿25(OH)D水平均明显低于对照组(P< 0.05)。ADHD组患儿25(OH)D水平正常、不足及缺乏的比例分布情况与对照组比较差异有统计学意义(P< 0.01);且各亚型ADHD患儿25(OH)D水平的分布情况与对照组比较差异均有统计学意义(P< 0.05)。结论 ADHD患儿25(OH)D水平明显低于健康儿童,25(OH)D水平与ADHD可能存在一定的相关性。

Abstract

Objective To examine serum 25-hydroxyvitamin D levels in children with attention deficit hyperactivity disorder (ADHD) and to explore the relationship between vitamin D level and ADHD. Methods Ninety-seven children with ADHD who were diagnosed according to DSM-V were selected as the ADHD group, including 46 cases of ADHD-I, 10 cases of ADHD-HI, and 41 cases of ADHD-C. Ninety-seven healthy children served as the control group. Serum levels of 25-hydroxyvitamin D were measured using electrochemiluminescence immunoassay. Results Mean serum levels of 25-hydroxyvitamin D in the ADHD group (17±7 ng/mL) were significantly lower than in the control group (23±8 ng/mL; P< 0.01). The serum levels of 25-hydroxyvitamin D in the three subtypes groups of ADHD (ADHD-I, ADHD-HI, and ADHD-C) were all lower than in the control group (P< 0.05). The rates of vitamin D insufficiency, deficiency or normal in the ADHD group were different from the control group (P< 0.01). The distributions of vitamin D levels in the three subtypes groups of ADHD were all different from the control group (P< 0.05). Conclusions Serum levels of 25-hydroxyvitamin D in children with ADHD are lower than in healthy children, suggesting vitamin D level might be related to ADHD.

导出引用

上官莉莉, 赵亚茹. 注意缺陷多动障碍患儿血清25羟基维生素D水平的检测[J]. 中国当代儿科杂志. 2015, 17(8): 837-840 https://doi.org/10.7499/j.issn.1008-8830.2015.08.015

SHANG-GUAN Li-Li, ZHAO Ya-Ru. Serum levels of 25-hydroxyvitamin D in children with attention deficit hyperactivity disorder[J]. Chinese Journal of Contemporary Pediatrics. 2015, 17(8): 837-840 https://doi.org/10.7499/j.issn.1008-8830.2015.08.015

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