Abstract：Objective To explore the changes in T helper lymphocytes and their subsets in children with tic disorders (TD) and their clinical signifcance.Methods Flow cytometry was used to measure the percentages of T helper lymphocytes and their subsets in the peripheral blood of children with TD and healthy children (controls).Results The percentage of T helper lymphocytes was signifcantly lower in the TD group than in the control group (P < 0.001). The abnormal rate of T helper lymphocytes in the TD group was signifcantly higher than that in the control group (68.7% vs 18.8%; P < 0.001). The percentage of T helper lymphocytes was negatively correlated with Yale Global Tic Severity Scale score (r=-0.3945, P < 0.001). As for the subsets of T helper lymphocytes, the TD group had a signifcantly higher percentage of Th1 cells and a signifcantly lower percentage of Th2 cells compared with the control group (P < 0.001).Conclusions The abnormality of T helper lymphocytes and the imbalance of their subsets may be associated with the pathogenesis of TD in children. The percentage of T helper lymphocytes can be used as an indicator for assessing the severity of TD.
HOU Xiao-Jun,LIN Shan,LIN Xiang-Quan et al. Changes in T helper lymphocytes and their subsets in children with tic disorders[J]. CJCP, 2018, 20(7): 519-523.
Leckman JF, Riddle MA, Hardin MT, et al. The Yale Global Tic Severity Scale:initial testing of a clinician-rated of tic severity[J]. J Am Acad Child Adolesc Psychiatry, 1989, 28(4):566-573.
[4]
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV)[M]. Washington DC:American Psychiatric Association, 1994:100-105.
[5]
Georgitsi M, Willsey AJ, Mathews CA, et al. The genetic etiology of Tourette syndrome:large-scale collaborative efforts on the precipice of discovery[J]. Front Neurosci, 2016, 10:351.
[6]
Moya PR, Wendland JR, Rubenstein LM, et al. Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette's disorder[J]. Mov Disord, 2013, 28(9):1263-1270.
Martino D, Zis P, Buttiglione M. The role of immune mechanisms in Tourette syndrome[J]. Brain Res, 2015, 1617:126-143.
[10]
Spinello C, Laviola G, Macrì S. Pediatric autoimmune disorders associated with streptococcal infections and Tourette's syndrome in preclinical studies[J]. Front Neurosci, 2016, 10:310.
