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原发性遗尿症儿童工作记忆缺陷的事件相关电位研究
朱洁, 董选, 赵方乔, 顾晓艳, 董谕, 丁立
中国当代儿科杂志 ›› 2018, Vol. 20 ›› Issue (12) : 1040-1043.
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PDF(1281 KB)
原发性遗尿症儿童工作记忆缺陷的事件相关电位研究
Event-related potentials of working memory impairment in children with primary nocturnal enuresis
目的 通过事件相关电位（ERP）探讨原发性遗尿症儿童工作记忆障碍的认知神经机制。方法 纳入原发性遗尿症（遗尿症组）与正常儿童（对照组）各14例，采用学习-再认任务测试，对两组儿童识别旧图（学习过的）及新图（未学习过的）时Fz导联ERP成分P2、N2、P3进行比较分析。结果 遗尿症组识别旧图时P2、N2波幅明显低于对照组（P < 0.05）；而两组识别旧图时P2、N2、P3潜伏期及P3波幅差异均无统计学意义。遗尿症组识别新图时P2潜伏期较对照组明显延长（P < 0.05），N2波幅明显低于对照组（P < 0.05）；而两组识别新图时P2、P3波幅及N2、P3潜伏期差异均无统计学意义。结论 原发性遗尿症儿童比正常儿童记忆分类信息提取能力下降及反应时延长，记忆容量负荷减少、记忆巩固减弱及冲突监测能力下降，导致工作记忆障碍。
Objective To study the cognitive neural mechanism of working memory impairment in children with primary nocturnal enuresis using event-related potential (ERP).Methods A total of 14 children with primary nocturnal enuresis were enrolled as enuresis group, and 14 normal children were enrolled as control group. The learning-recognition task test was applied, and the ERP components (P2, N2, and P3) at Fz lead while identifying old pictures (learned) and new ones (unlearned) were measured and compared between the two groups.Results While identifying the old pictures, the enuresis group had a lower amplitude of P2 and N2 than the control group (P < 0.05). There were no significant differences between the two groups in the latency of P2, N2, and P3 and the amplitude of P3. While identifying the new pictures, the enuresis group had a longer latency of P2 and a significantly lower amplitude of N2 than the control group (P < 0.05). There were no significant differences between the two groups in the amplitude of P2 and P3 and the latency of N2 and P3.Conclusions Compared with normal children, the children with primary nocturnal enuresis have reduced abilities of classified information extraction, a prolonged reaction time, and reductions in memory capacity, memory consolidation, and conflict monitoring, which causes working memory impairment.
Enuresis / Working memory impairment / Event-related potential / Child
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常州市科技计划项目（CJ20160014）。
