印度尼西亚儿童牛奶摄入与乳糖吸收不良之间的关系

MunadzilahSyarimonitha; HegarBadriul; SekartiniRini; VandenplasYvan

doi:10.7499/j.issn.1008-8830.2105030

PDF(428 KB)

HTML

中国当代儿科杂志 ›› 2021, Vol. 23 ›› Issue (10) : 975-980. DOI: 10.7499/j.issn.1008-8830.2105030

国外儿科研究动态

印度尼西亚儿童牛奶摄入与乳糖吸收不良之间的关系

MunadzilahSyarimonitha, HegarBadriul, SekartiniRini, VandenplasYvan

作者信息 +

Association between milk consumption and lactose malabsorption in Indonesian children

Munadzilah Syarimonitha, Hegar Badriul, Sekartini Rini, Vandenplas Yvan

Author information +

文章历史 +

摘要

目的探讨3~12岁印度尼西亚儿童牛奶摄入与乳糖吸收不良之间的关系。方法该研究为横断面研究。研究对象为在印度尼西亚雅加达中部随机选取的营养状况良好的174名3~12岁健康儿童，包括72名3~5岁儿童和102名6~12岁儿童。结果 3~5岁儿童乳糖吸收不良患病率为20.8%（15/72），6~12岁儿童乳糖吸收不良患病率为35.3%（36/102）。牛奶或乳制品摄入与乳糖吸收不良之间无显著关联性（P>0.05）。在氢呼气试验中，51例乳糖吸收不良儿童主要表现为腹泻（62%）、腹痛（52%）和恶心（5%）。结论 3~12岁印度尼西亚儿童牛奶摄入和乳糖吸收不良无关联，这提示遗传易感性可能比乳糖摄入的适应机制更重要。

Abstract

Objective To study the association between milk consumption and lactose malabsorption in Indonesian children aged 3-12 years. Methods This cross sectional study was conducted in randomly selected presumed healthy children with good nutritional status aged 3-12 years in Central Jakarta, Indonesia (n=174), including 72 children aged 3-5 years and 102 children aged 6-12 years. Results The prevalence of lactose malabsorption in children aged 3-5 years and children aged 6-12 years was 20.8% (15/72) and 35.3% (36/102), respectively. There was no association between milk or milk product consumption and lactose malabsorption (P>0.05). In the 51 children with lactose malabsorption, the predominant clinical symptoms were diarrhea (62%), abdominal pain (52%), and nausea (5%) during the hydrogen breath test. Conclusions There is no association between milk consumption and lactose malabsorption in Indonesian children aged 3-12 years, suggesting that genetic predisposition may be more important than adaptive mechanisms to lactose consumption.

导出引用

MunadzilahSyarimonitha, HegarBadriul, SekartiniRini, VandenplasYvan. 印度尼西亚儿童牛奶摄入与乳糖吸收不良之间的关系[J]. 中国当代儿科杂志. 2021, 23(10): 975-980 https://doi.org/10.7499/j.issn.1008-8830.2105030

Munadzilah Syarimonitha, Hegar Badriul, Sekartini Rini, Vandenplas Yvan. Association between milk consumption and lactose malabsorption in Indonesian children[J]. Chinese Journal of Contemporary Pediatrics. 2021, 23(10): 975-980 https://doi.org/10.7499/j.issn.1008-8830.2105030

参考文献

1 CatanzaroR, SciutoM, MarottaF. Lactose intolerance: an update on its pathogenesis, diagnosis, and treatment[J]. Nutr Res, 2021, 89: 23-34. PMID: 33887513. DOI: 10.1016/j.nutres.2021.02.003.
2 TishkoffSA, ReedFA, RanciaroA, et al. Convergent adaptation of human lactase persistence in Africa and Europe[J]. Nat Genet, 2007, 39(1): 31-40. PMID: 17159977. PMCID: PMC2672153.DOI: 10.1038/ng1946.
3 DzialanskiZ, BaranyM, EngfeldtP, et al. Lactase persistence versus lactose intolerance: is there an intermediate phenotype?[J]. Clin Biochem, 2016, 49(3): 248-252. PMID: 26601570. DOI: 10.1016/j.clinbiochem.2015.11.001.
4 HeymanMB, Committee on Nutrition. Lactose intolerance in infants, children, and adolescents[J]. Pediatrics, 2006, 118(3): 1279-1286. PMID: 16951027. DOI: 10.1542/peds.2006-1721.
5 Ministry of Agriculture. Outlook for dairy, commoditiesagricultural, sub-sectorlivestock, data center and agricultural information systems, Secretariat General of the Ministry of Agriculture, Jakarta. 2016[EB/OL]. [April 10, 2021]. https://docplayer.info/46230584-Outlook-komoditas-pertanian-subsektor-peternakan-susu.html.
6 Suharjono, Sunoto, BudiarsoA, et al. Lactose malabsorption in "healthy" Indonesian pre-school children[J]. Paediatr Indones, 1971, 11(6): 251-254. PMID: 5154768.
7 HegarB, FirmansyahA, BoediarsoA. The activity of the enzyme lactase in toddlers[J]. Majalah Kesehatan Masyarakat Indonesia, 1997, 2(5): 135-137.
8 HegarB, PritayatiN, FirmansyahA. Lactase activity in elementary school children[J]. Maj Kedokt Indon, 2001, 51(5): 154-157.
9 BaadkarSV, MukherjeeMS, LeleSS. Study on influence of age, gender and genetic variants on lactose intolerance and its impact on milk intake in adult Asian Indians[J]. Ann Hum Biol, 2014, 41(6): 548-553. PMID: 24734931. DOI: 10.3109/03014460.2014.902992.
10 PerinoA, CabrasS, ObinuD, et al. Lactose intolerance: a non-allergic disorder often managed by allergologists[J]. Eur Ann Allergy Clin Immunol, 2009, 41(1): 3-16. PMID: 19496347.
11 YangY, HeM, CuiH, et al. The prevalence of lactase deficiency and lactose intolerance in Chinese children of different ages[J]. Chin Med J (Engl), 2000, 113(12): 1129-1132. PMID:11776151.
12 BarlingPM. Lactose tolerance and intolerance in Malaysians[J]. Int J Sci Educ, 2012, 6(Suppl 1): S12-S23.
13 BaylessTM, BrownE, PaigeDM. Lactase non-persistence and lactose intolerance[J]. Curr Gastroenterol Rep, 2017, 19(5): 23. PMID: 28421381. DOI: 10.1007/s11894-017-0558-9.
14 BudiarsoAD, SofiaD, HadinegoroSR, et al. Lactose malabsorption in junior high school children[J]. Paediat Indones, 2003, 42(3): 46-50.
15 VandenplasY. Lactose intolerance[J]. Asia Pac J Clin Nutr, 2015, 24(Suppl 1): S9-S13. PMID: 26715083. DOI: 10.6133/apjcn.2015.24.s1.02.
16 HarveyL, LudwigT, HouAQ, et al. Prevalence, cause and diagnosis of lactose intolerance in children aged 1-5 years: a systematic review of 1995-2015 literature[J]. Asia Pac J Clin Nutr, 2018, 27(1): 29-46. PMID: 29222879. DOI: 10.6133/apjcn.022017.05.
17 BaadkarSV, MukherjeeMS, LeleSS. A study on genetic test of lactase persistence in relation to milk consumption in regional groups of India[J]. Genet Test Mol Biomarkers, 2012, 16(12): 1413-1418. PMID: 23030683. DOI: 10.1089/gtmb.2012.0191.
18 DuX, GrayP. Evolution of lactase persistence[J]. Western Undergraduate Research Journal: Health and Natural Sciences, 2017, 8(1): 18-28.
19 SilanikoveN, LeitnerG, MerinU. The interrelationships between lactose intolerance and the modern dairy industry: global perspectives in evolutional and historical backgrounds[J]. Nutrients, 2015, 7(9): 7312-7331. PMID: 26404364. PMCID: PMC4586535. DOI: 10.3390/nu7095340.
20 PermanJA, ModlerS, BarrRG, et al. Fasting breath hydrogen concentration: normal values and clinical application[J]. Gastroenterology, 1984, 87(6): 1358-1363. PMID: 6489700.
21 GardinerAJ, TarlowMJ, SutherlandIT, et al. Lactose malabsorption during gastroenteritis, assessed by the hydrogen breath test[J]. Arch Dis Child, 1981, 56(5): 364-367. PMID: 7259257. PMCID: PMC1627444. DOI: 10.1136/adc.56.5.364.
22 MisselwitzB, ButterM, VerbekeK, et al. Update on lactose malabsorption and intolerance: pathogenesis, diagnosis and clinical management[J]. Gut, 2019, 68(11): 2080-2091. PMID: 31427404. PMCID: PMC6839734. DOI: 10.1136/gutjnl-2019-318404.