早产儿校正24月龄内生长轨迹研究

宋绮莹, 赵晓丽, 郭玉琴, 丁碧蓝, 彭琼玲, 马丽亚

中国当代儿科杂志 ›› 2021, Vol. 23 ›› Issue (12) : 1200-1207.

PDF(1600 KB)
HTML
PDF(1600 KB)
HTML
中国当代儿科杂志 ›› 2021, Vol. 23 ›› Issue (12) : 1200-1207. DOI: 10.7499/j.issn.1008-8830.2108129
论著·临床研究

早产儿校正24月龄内生长轨迹研究

  • 宋绮莹1,2, 赵晓丽3, 郭玉琴3, 丁碧蓝3, 彭琼玲3, 马丽亚3
作者信息 +

Assessment of growth pattern of preterm infants up to a corrected age of 24 months

  • SONG Qi-Ying, ZHAO Xiao-Li, GUO Yu-Qin, DING Bi-Lan, PENG Qiong-Ling, MA Li-Ya
Author information +
文章历史 +

摘要

目的 分析早产儿校正24月龄内生长轨迹,以了解早产儿的生长趋势和规律。 方法 基于互联网+随访系统建立早产儿随访数据库,纳入2018年4月至2021年4月3 188例早产儿,收集其出生及校正1、3、6、12、18、24月龄时的身长、体重、头围数据。按不同的围生期因素分组,绘制生长曲线,并与21世纪国际胎儿和新生儿生长联合会(International Fetal and Newborn Growth Consortium for the 21st Century,INTERGROWTH-21st)标准和世界卫生组织(World Health Organization,WHO)标准进行比较。 结果 按不同的围生期因素分组的各组早产儿体重、身长、头围曲线均在校正6月龄内快速上升,校正6月龄后增长速度减缓。按实际月龄比较,各出生胎龄组早产儿(<28周、28~31+6周、32~33+6周、34~36+6周)身长曲线在实际9月龄后逐渐与WHO曲线重合(P=0.082),<32周早产儿的体重和头围则一直落后于WHO曲线(P<0.001)。校正月龄后,不同出生胎龄组早产儿(<28周、28~31+6周、32~33+6周、34~36+6周)的体格生长曲线基本重合(P>0.05)。超低出生体重儿和小于胎龄儿的身长、体重、头围曲线均低于INTERGROWTH-21st标准和WHO标准(P<0.05)。 结论 早产儿在校正6月龄内体格增长速度较快,校正6月龄后增长速度减缓。胎龄越小,体重和头围追赶的时间越长。应重点关注超早产儿、超低出生体重儿和小于胎龄儿的体格生长。

Abstract

Objective To assess the growth of preterm infants up to a corrected age of 24 months, and to understand the growth trend and pattern of preterm infants. Methods A preterm infant follow-up database was established based on the Internet Plus follow-up system. A total of 3 188 preterm infants who were born from April 2018 to April 2021 were enrolled. Their length, weight, and head circumference were recorded at birth and at the corrected ages of 1, 3, 6, 12, 18, and 24 months. The preterm infants were grouped by perinatal factors. The growth curves of these infants were plotted and compared with the International Fetal and Newborn Growth Consortium for the 21st Century (INTERGROWTH-21st) standard and World Health Organization (WHO) standard. Results The weight, length, and head circumference curves of each group of preterm infants grouped by various perinatal factors all rose rapidly within the corrected age of 6 months, but the growth rate slowed down after the corrected age of 6 months. Based on the actual age for the groups of preterm infants with different gestational ages (<28 weeks, 28-31+6 weeks, 32-33+6 weeks, and 34-36+6 weeks), the length curve gradually coincided with the WHO curve after the actual age of 9 months (P=0.082), while for the preterm infants with a gestational age of <32 weeks, the weight and head circumference curves were significantly lower than the WHO curves (P<0.001). Based on the corrected age, the physical growth curve of preterm infants with different gestational ages (<28 weeks, 28-31+6 weeks, 32-33+6 weeks, and 34-36+6 weeks) basically coincided with each other (P>0.05). For the infants with extremely low birth weight and the small-for-gestational-age infants, the length, weight, and head circumference curves were significantly lower than those of the INTERGROWTH-21st standard and the WHO standard (P<0.05). Conclusions The physical growth rate of preterm infants is faster within the corrected age of 6 months, and the growth rate slows down after the corrected age of 6 months. Preterm infants with a smaller gestational age need longer time to catch up in weight and head circumference. More attention should be paid to the physical growth of extremely preterm infants, extremely low birth weight infants, and small-for-gestational-age infants.

关键词

体格生长 / 生长曲线 / 早产儿

Key words

Physical growth / Growth curve / Preterm infant

引用本文

导出引用
宋绮莹, 赵晓丽, 郭玉琴, 丁碧蓝, 彭琼玲, 马丽亚. 早产儿校正24月龄内生长轨迹研究[J]. 中国当代儿科杂志. 2021, 23(12): 1200-1207 https://doi.org/10.7499/j.issn.1008-8830.2108129
SONG Qi-Ying, ZHAO Xiao-Li, GUO Yu-Qin, DING Bi-Lan, PENG Qiong-Ling, MA Li-Ya. Assessment of growth pattern of preterm infants up to a corrected age of 24 months[J]. Chinese Journal of Contemporary Pediatrics. 2021, 23(12): 1200-1207 https://doi.org/10.7499/j.issn.1008-8830.2108129

参考文献

1 Chawanpaiboon S, Vogel JP, Moller AB, et al. Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis[J]. Lancet Glob Health, 2019, 7(1): e37-e46. PMID: 30389451. PMCID: PMC6293055. DOI: 10.1016/S2214-109X(18)30451-0.
2 World Health Organization. WHO child growth standards: growth velocity based on weight, length and head circumference: methods and development[EB/OL]. (2009-11-12)[2021-06-09]. https://www.who.int/publications/i/item/9789241547635.
3 Villar J, Giuliani F, Bhutta ZA, et al. Postnatal growth standards for preterm infants: the Preterm Postnatal Follow-up Study of the INTERGROWTH-21st Project[J]. Lancet Glob Health, 2015, 3(11): e681-e691. PMID: 26475015. DOI: 10.1016/S2214-109X(15)00163-1.
4 INTERGROWTH-21st. Postnatal growth of preterm infants[EB/OL]. [2021-06-09]. https://intergrowth21.tghn.org/postnatal-growth-preterm-infants/.
5 彭琼玲, 赵晓丽, 丁建英, 等. 早产儿矫正5~7月龄的体格和神经心理发育水平研究[J]. 中国妇幼卫生杂志, 2020, 11(4): 30-33. DOI: 10.19757/j.cnki.issn1674-7763.2020.04.007.
6 陈荣华, 赵正言, 刘湘云. 儿童保健学[M]. 南京: 江苏凤凰科学技术出版社, 2017: 12-13.
7 朱丽, 张蓉, 张淑莲, 等. 中国不同胎龄新生儿出生体重曲线研制[J]. 中华儿科杂志, 2015, 53(2): 97-103. PMID: 25876683. DOI: 10.3760/cma.j.issn.0578-1310.2015.02.007.
8 熊菲, 毛萌. 早产儿生后体格生长评价[J]. 中华儿科杂志, 2019, 57(4): 318-320. PMID: 30934212. DOI: 10.3760/cma.j.issn.0578-1310.2019.04.021.
9 屈小莉, 杨玉兰, 刘世新, 等. 超早产儿校正月龄24月龄内体格生长分析[J]. 中华儿科杂志, 2020, 58(12): 982-988. PMID: 33256320. DOI: 10.3760/cma.j.cn112140-20200628-00670.
10 张莉. 早产儿出生后早期的生长水平和模式及其影响因素分析[D]. 济南: 山东大学, 2019.
11 van Dommelen P, de Gunst M, van der Vaart A, et al. Growth references for height, weight and body mass index of twins aged 0-2.5 years[J]. Acta Paediatr, 2008, 97(8): 1099-1104. PMID: 18460042. DOI: 10.1111/j.1651-2227.2008.00853.x.

基金

深圳市科技创新委员会(JCYJ201908809183601667);中国疾病预防控制中心妇幼保健中心合生元母婴营养与健康研究项目(2018FYH015);深圳市宝安区妇幼保健院科研基金(BAFY 2021001)。


PDF(1600 KB)
HTML

Accesses

Citation

Detail

段落导航
相关文章

/