Preeclampsia (PE) is a unique complication of pregnancy that affects the health of the mother and the infant. Intestinal flora plays an important regulatory role in human body's metabolism and immunity and is associated with many diseases. Studies have shown that the development and progression of PE can lead to alterations in intestinal flora in the mother and are even closely associated with the colonization and development of intestinal flora in the offspring. This article reviews related studies on the effect of PE on maternal-infant intestinal flora, so as to provide new ideas for the prevention and treatment of maternal and infant complications associated with PE.
YANG Yue.
Recent research on the effect of preeclampsia on maternal-infant intestinal flora interactions[J]. Chinese Journal of Contemporary Pediatrics. 2022, 24(1): 102-107 https://doi.org/10.7499/j.issn.1008-8830.2110034
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参考文献
1 Mol BWJ, Roberts CT, Thangaratinam S, et al. Pre-eclampsia[J]. Lancet, 2016, 387(10022): 999-1011. PMID: 26342729. DOI: 10.1016/S0140-6736(15)00070-7. 2 von Ehr J, von Versen-H?ynck F. Implications of maternal conditions and pregnancy course on offspring's medical problems in adult life[J]. Arch Gynecol Obstet, 2016, 294(4): 673-679. PMID: 27522600. DOI: 10.1007/s00404-016-4178-7. 3 Bokslag A, van Weissenbruch M, Mol BW, et al. Preeclampsia; short and long-term consequences for mother and neonate[J]. Early Hum Dev, 2016, 102: 47-50. PMID: 27659865. DOI: 10.1016/j.earlhumdev.2016.09.007. 4 Phipps EA, Thadhani R, Benzing T, et al. Pre-eclampsia: pathogenesis, novel diagnostics and therapies[J]. Nat Rev Nephrol, 2019, 15(5): 275-289. PMID: 30792480. PMCID: PMC6472952. DOI: 10.1038/s41581-019-0119-6. 5 Sarkar A, Yoo JY, Valeria Ozorio Dutra S, et al. The association between early-life gut microbiota and long-term health and diseases[J]. J Clin Med, 2021, 10(3): 459. PMID: 33504109. PMCID: PMC7865818. DOI: 10.3390/jcm10030459. 6 Morrison DJ, Preston T. Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism[J]. Gut Microbes, 2016, 7(3): 189-200. PMID: 26963409. PMCID: PMC4939913. DOI: 10.1080/19490976.2015.1134082. 7 Yang Y, Palm NW. Immunoglobulin A and the microbiome[J]. Curr Opin Microbiol, 2020, 56: 89-96. PMID: 32889295. DOI: 10.1016/j.mib.2020.08.003. 8 Chen ZF, Ruan JS, Li DH, et al. The role of intestinal bacteria and gut-brain axis in hepatic encephalopathy[J]. Front Cell Infect Microbiol, 2020, 10: 595759. PMID: 33553004. PMCID: PMC7859631. DOI: 10.3389/fcimb.2020.595759. 9 Yang XY, Lu D, Zhuo JY, et al. The gut-liver axis in immune remodeling: new insight into liver diseases[J]. Int J Biol Sci, 2020, 16(13): 2357-2366. PMID: 32760203. PMCID: PMC7378637. DOI: 10.7150/ijbs.46405. 10 Smid MC, Ricks NM, Panzer A, et al. Maternal gut microbiome biodiversity in pregnancy[J]. Am J Perinatol, 2018, 35(1): 24-30. PMID: 28750469. PMCID: PMC6102712. DOI: 10.1055/s-0037-1604412. 11 Koren O, Goodrich JK, Cullender TC, et al. Host remodeling of the gut microbiome and metabolic changes during pregnancy[J]. Cell, 2012, 150(3): 470-480. PMID: 22863002. PMCID: PMC3505857. DOI: 10.1016/j.cell.2012.07.008. 12 Aatsinki AK, Uusitupa HM, Munukka E, et al. Gut microbiota composition in mid-pregnancy is associated with gestational weight gain but not prepregnancy body mass index[J]. J Womens Health (Larchmt), 2018, 27(10): 1293-1301. PMID: 29757063. PMCID: PMC6205042. DOI: 10.1089/jwh.2017.6488. 13 DiGiulio DB, Callahan BJ, McMurdie PJ, et al. Temporal and spatial variation of the human microbiota during pregnancy[J]. Proc Natl Acad Sci U S A, 2015, 112(35): 11060-11065. PMID: 26283357. PMCID: PMC4568272. DOI: 10.1073/pnas.1502875112. 14 Lima VJD, Andrade CRD, Ruschi GE, et al. Serum lipid levels in pregnancies complicated by preeclampsia[J]. Sao Paulo Med J, 2011, 129(2): 73-76. PMID: 21603783. DOI: 10.1590/s1516-31802011000200004. 15 Liu J, Yang H, Yin Z, et al. Remodeling of the gut microbiota and structural shifts in preeclampsia patients in South China[J]. Eur J Clin Microbiol Infect Dis, 2017, 36(4): 713-719. PMID: 27988814. DOI: 10.1007/s10096-016-2853-z. 16 Lv LJ, Li SH, Li SC, et al. Early-onset preeclampsia is associated with gut microbial alterations in antepartum and postpartum women[J]. Front Cell Infect Microbiol, 2019, 9: 224. PMID: 31297341. PMCID: PMC6608563. DOI: 10.3389/fcimb.2019.00224. 17 Chen X, Li P, Liu M, et al. Gut dysbiosis induces the development of pre-eclampsia through bacterial translocation[J]. Gut, 2020, 69(3): 513-522. PMID: 31900289. DOI: 10.1136/gutjnl-2019-319101. 18 Gomez-Arango LF, Barrett HL, McIntyre HD, et al. Increased systolic and diastolic blood pressure is associated with altered gut microbiota composition and butyrate production in early pregnancy[J]. Hypertension, 2016, 68(4): 974-981. PMID: 27528065. DOI: 10.1161/HYPERTENSIONAHA.116.07910. 19 Ahmadian E, Rahbar Saadat Y, Hosseiniyan Khatibi SM, et al. Pre-eclampsia: microbiota possibly playing a role[J]. Pharmacol Res, 2020, 155: 104692. PMID: 32070720. DOI: 10.1016/j.phrs.2020.104692. 20 Richards EM, Pepine CJ, Raizada MK, et al. The gut, its microbiome, and hypertension[J]. Curr Hypertens Rep, 2017, 19(4): 36. PMID: 28444579. PMCID: PMC5846192. DOI: 10.1007/s11906-017-0734-1. 21 Xie F, Turvey SE, Williams MA, et al. Toll-like receptor signaling and pre-eclampsia[J]. Am J Reprod Immunol, 2010, 63(1): 7-16. PMID: 20059464. DOI: 10.1111/j.1600-0897.2009.00745.x. 22 Eghbal-Fard S, Yousefi M, Heydarlou H, et al. The imbalance of Th17/Treg axis involved in the pathogenesis of preeclampsia[J]. J Cell Physiol, 2019, 234(4): 5106-5116. PMID: 30277561. DOI: 10.1002/jcp.27315. 23 Janeiro MH, Ramírez MJ, Milagro FI, et al. Implication of trimethylamine N-oxide (TMAO) in disease: potential biomarker or new therapeutic target[J]. Nutrients, 2018, 10(10): 1398. PMID: 30275434. PMCID: PMC6213249. DOI: 10.3390/nu10101398. 24 Kim S, Rigatto K, Gazzana MB, et al. Altered gut microbiome profile in patients with pulmonary arterial hypertension[J]. Hypertension, 2020, 75(4): 1063-1071. PMID: 32088998. PMCID: PMC7067661. DOI: 10.1161/HYPERTENSIONAHA.119.14294. 25 Sun BM, Meng L, Liu H, et al. Changes in intestinal flora in preeclampsia rats and effects of probiotics on their inflammation and blood pressure[J]. Eur Rev Med Pharmacol Sci, 2020, 24(19): 10155-10161. PMID: 33090423. DOI: 10.26355/eurrev_202010_23235. 26 Brantsaeter AL, Myhre R, Haugen M, et al. Intake of probiotic food and risk of preeclampsia in primiparous women: the Norwegian mother and child cohort study[J]. Am J Epidemiol, 2011, 174(7): 807-815. PMID: 21821542. PMCID: PMC3203379. DOI: 10.1093/aje/kwr168. 27 Nordqvist M, Jacobsson B, Brants?ter AL, et al. Timing of probiotic milk consumption during pregnancy and effects on the incidence of preeclampsia and preterm delivery: a prospective observational cohort study in Norway[J]. BMJ Open, 2018, 8(1): e018021. PMID: 29362253. PMCID: PMC5780685. DOI: 10.1136/bmjopen-2017-018021. 28 DiGiulio DB, Romero R, Amogan HP, et al. Microbial prevalence, diversity and abundance in amniotic fluid during preterm labor: a molecular and culture-based investigation[J]. PLoS One, 2008, 3(8): e3056. PMID: 18725970. PMCID: PMC2516597. DOI: 10.1371/journal.pone.0003056. 29 Aagaard K, Ma J, Antony KM, et al. The placenta harbors a unique microbiome[J]. Sci Transl Med, 2014, 6(237): 237ra65. PMID: 24848255. PMCID: PMC4929217. DOI: 10.1126/scitranslmed.3008599. 30 Milani C, Duranti S, Bottacini F, et al. The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota[J]. Microbiol Mol Biol Rev, 2017, 81(4): e00036-17. PMID: 29118049. PMCID: PMC5706746. DOI: 10.1128/MMBR.00036-17. 31 Biasucci G, Rubini M, Riboni S, et al. Mode of delivery affects the bacterial community in the newborn gut[J]. Early Hum Dev, 2010, 86(Suppl 1): 13-15. PMID: 20133091. DOI: 10.1016/j.earlhumdev.2010.01.004. 32 Ficara M, Pietrella E, Spada C, et al. Changes of intestinal microbiota in early life[J]. J Matern Fetal Neonatal Med, 2020, 33(6): 1036-1043. PMID: 30058404. DOI: 10.1080/14767058.2018.1506760. 33 Arboleya S, Sánchez B, Solís G, et al. Impact of prematurity and perinatal antibiotics on the developing intestinal microbiota: a functional inference study[J]. Int J Mol Sci, 2016, 17(5): 649. PMID: 27136545. PMCID: PMC4881475. DOI: 10.3390/ijms17050649. 34 Pannaraj PS, Li F, Cerini C, et al. Association between breast milk bacterial communities and establishment and development of the infant gut microbiome[J]. JAMA Pediatr, 2017, 171(7): 647-654. PMID: 28492938. PMCID: PMC5710346. DOI: 10.1001/jamapediatrics.2017.0378. 35 Ma JR, Li ZH, Zhang WJ, et al. Comparison of gut microbiota in exclusively breast-fed and formula-fed babies: a study of 91 term infants[J]. Sci Rep, 2020, 10(1): 15792. PMID: 32978424. PMCID: PMC7519658. DOI: 10.1038/s41598-020-72635-x. 36 Vandenplas Y, Carnielli VP, Ksiazyk J, et al. Factors affecting early-life intestinal microbiota development[J]. Nutrition, 2020, 78: 110812. PMID: 32464473. DOI: 10.1016/j.nut.2020.110812. 37 Collado MC, Isolauri E, Laitinen K, et al. Effect of mother's weight on infant's microbiota acquisition, composition, and activity during early infancy: a prospective follow-up study initiated in early pregnancy[J]. Am J Clin Nutr, 2010, 92(5): 1023-1030. PMID: 20844065. DOI: 10.3945/ajcn.2010.29877. 38 Su ML, Nie YY, Shao RC, et al. Diversified gut microbiota in newborns of mothers with gestational diabetes mellitus[J]. PLoS One, 2018, 13(10): e0205695. PMID: 30332459. PMCID: PMC6192631. DOI: 10.1371/journal.pone.0205695. 39 Wan Y, Jiang JJ, Lu MQ, et al. Human milk microbiota development during lactation and its relation to maternal geographic location and gestational hypertensive status[J]. Gut Microbes, 2020, 11(5): 1438-1449. PMID: 32543266. PMCID: PMC7524296. DOI: 10.1080/19490976.2020.1760711. 40 Wang JF, Zheng JY, Shi WY, et al. Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus[J]. Gut, 2018, 67(9): 1614-1625. PMID: 29760169. PMCID: PMC6109274. DOI: 10.1136/gutjnl-2018-315988. 41 Jiménez E, Marín ML, Martín R, et al. Is meconium from healthy newborns actually sterile?[J]. Res Microbiol, 2008, 159(3): 187-193. PMID: 18281199. DOI: 10.1016/j.resmic.2007.12.007. 42 Yin CH, Chen JR, Wu XN, et al. Preterm birth is correlated with increased oral originated microbiome in the gut[J]. Front Cell Infect Microbiol, 2021, 11: 579766. PMID: 34222033. PMCID: PMC8248533. DOI: 10.3389/fcimb.2021.579766. 43 Han YW. Fusobacterium nucleatum: a commensal-turned pathogen[J]. Curr Opin Microbiol, 2015, 23: 141-147. PMID: 25576662. PMCID: PMC4323942. DOI: 10.1016/j.mib.2014.11.013. 44 Liu HQ, Redline RW, Han YW. Fusobacterium nucleatum induces fetal death in mice via stimulation of TLR4-mediated placental inflammatory response[J]. J Immunol, 2007, 179(4): 2501-2508. PMID: 17675512. DOI: 10.4049/jimmunol.179.4.2501. 45 Seki D, Mayer M, Hausmann B, et al. Aberrant gut-microbiota-immune-brain axis development in premature neonates with brain damage[J]. Cell Host Microbe, 2021, 29(10): 1558-1572.e6. PMID: 34480872. PMCID: PMC8525911. DOI: 10.1016/j.chom.2021.08.004. 46 Amarasekara R, Jayasekara RW, Senanayake H, et al. Microbiome of the placenta in pre-eclampsia supports the role of bacteria in the multifactorial cause of pre-eclampsia[J]. J Obstet Gynaecol Res, 2015, 41(5): 662-669. PMID: 25492799. DOI: 10.1111/jog.12619. 47 Kaduma J, Seni J, Chuma C, et al. Urinary tract infections and preeclampsia among pregnant women attending two hospitals in Mwanza city, Tanzania: a 1:2 matched case-control study[J]. Biomed Res Int, 2019, 2019: 3937812. PMID: 31032344. PMCID: PMC6457296. DOI: 10.1155/2019/3937812. 48 Chang YL, Chen YY, Zhou Q, et al. Short-chain fatty acids accompanying changes in the gut microbiome contribute to the development of hypertension in patients with preeclampsia[J]. Clin Sci (Lond), 2020, 134(2): 289-302. PMID: 31961431. DOI: 10.1042/CS20191253. 49 Ni?o DF, Sodhi CP, Hackam DJ. Necrotizing enterocolitis: new insights into pathogenesis and mechanisms[J]. Nat Rev Gastroenterol Hepatol, 2016, 13(10): 590-600. PMID: 27534694. PMCID: PMC5124124. DOI: 10.1038/nrgastro.2016.119. 50 Zhang W, Ma C, Xie P, et al. Gut microbiota of newborn piglets with intrauterine growth restriction have lower diversity and different taxonomic abundances[J]. J Appl Microbiol, 2019, 127(2): 354-369. PMID: 31077497. PMCID: PMC6916403. DOI: 10.1111/jam.14304.