托法替尼在儿童风湿性疾病中的研究进展

周仕海; 熊亚群; 陈雅

doi:10.7499/j.issn.1008-8830.2201081

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中国当代儿科杂志 ›› 2022, Vol. 24 ›› Issue (4) : 447-453. DOI: 10.7499/j.issn.1008-8830.2201081

综述

托法替尼在儿童风湿性疾病中的研究进展

周仕海^1,2, 熊亚群^1,3, 陈雅^1,2

作者信息 +

Recent research on tofacitinib in the treatment of pediatric rheumatic diseases

ZHOU Shi-Hai, XIONG Ya-Qun, CHEN Ya

Author information +

文章历史 +

摘要

托法替尼是一种Janus激酶抑制剂，能够阻断Janus激酶和相关的信号转导及转录激活因子信号转导通路，减少多种细胞因子的生成与释放，具有治疗多种风湿病的潜力，其优点是起效快、能减少对糖皮质激素的依赖和相关不良事件。托法替尼在成人患者中的治疗作用已被证实，近年来已越来越多应用于儿童患者中，该文就托法替尼在儿童风湿病中的临床应用作一综述。

Abstract

Tofacitinib is a Janus kinase inhibitor and can block the Janus kinase-signal transducer and activator of transcription signal transduction pathway and reduce the production and release of a variety of cytokines. It has great potential in the treatment of various rheumatic diseases with a rapid onset of action and can reduce corticosteroid dependence and related adverse events. The therapeutic effect of tofacitinib in adult patients has been confirmed, and it has been increasingly used in pediatric patients in recent years. This article reviews the clinical application of tofacitinib in the treatment of pediatric autoimmune diseases.

导出引用

周仕海, 熊亚群, 陈雅. 托法替尼在儿童风湿性疾病中的研究进展[J]. 中国当代儿科杂志. 2022, 24(4): 447-453 https://doi.org/10.7499/j.issn.1008-8830.2201081

ZHOU Shi-Hai, XIONG Ya-Qun, CHEN Ya. Recent research on tofacitinib in the treatment of pediatric rheumatic diseases[J]. Chinese Journal of Contemporary Pediatrics. 2022, 24(4): 447-453 https://doi.org/10.7499/j.issn.1008-8830.2201081

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