青少年抑郁障碍与基因多态性的研究进展

姚珂珂; 董强利; 叶兰仙

doi:10.7499/j.issn.1008-8830.2208178

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中国当代儿科杂志 ›› 2023, Vol. 25 ›› Issue (3) : 328-332. DOI: 10.7499/j.issn.1008-8830.2208178

综述

青少年抑郁障碍与基因多态性的研究进展

姚珂珂, 董强利, 叶兰仙

作者信息 +

Recent research on the association between depressive disorder and gene polymorphisms in adolescents

YAO Ke-Ke, DONG Qiang-Li, YE Lan-Xian

Author information +

文章历史 +

摘要

生物遗传学在青少年抑郁障碍发病过程中发挥重要作用，基因多态性研究更新了对青少年抑郁障碍的理解。然而，在基因-环境相互作用及青少年发育年龄因素的影响下，基因多态性对青少年抑郁障碍的影响错综复杂。研究并阐明抑郁相关基因多态性与青少年抑郁障碍的关系有助于抑郁障碍发病机制的研究，为青少年时期抑郁障碍的预防和治疗提供新的线索。该文围绕青少年抑郁障碍的相关基因多态性进行了综述。

Abstract

Biogenetics plays an important role in the pathogenesis of depressive disorder in adolescents. Various genetic polymorphism studies have updated the understanding of adolescent depressive disorder. However, due to the influence of gene-environment interaction and age of puberty, the influence of gene polymorphisms on adolescent depressive disorder is complicated to clarify. Investigating and clarifying the relationship between gene polymorphisms and adolescent depressive disorder will promote the research on the pathogenesis of this disorder and provide a reference for the prevention and treatment of this disorder. This article reviews the genetic polymorphisms related to adolescent depressive disorder.

导出引用

姚珂珂, 董强利, 叶兰仙. 青少年抑郁障碍与基因多态性的研究进展[J]. 中国当代儿科杂志. 2023, 25(3): 328-332 https://doi.org/10.7499/j.issn.1008-8830.2208178

YAO Ke-Ke, DONG Qiang-Li, YE Lan-Xian. Recent research on the association between depressive disorder and gene polymorphisms in adolescents[J]. Chinese Journal of Contemporary Pediatrics. 2023, 25(3): 328-332 https://doi.org/10.7499/j.issn.1008-8830.2208178

参考文献

1 Lu J, Xu X, Huang Y, et al. Prevalence of depressive disorders and treatment in China: a cross-sectional epidemiological study[J]. Lancet Psychiatry, 2021, 8(11): 981-990. PMID: 34559991. DOI: 10.1016/S2215-0366(21)00251-0.
2 GBD 2019 Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the global burden of disease study 2019[J]. Lancet, 2020, 396(10258): 1204-1222. PMID: 33069326. PMCID: PMC7567026. DOI: 10.1016/S0140-6736(20)30925-9.
3 徐伏莲, 黄奕祥. 青少年抑郁症状研究进展[J]. 中国学校卫生, 2013, 34(2): 255-256. DOI: 10.16835/j.cnki.1000-9817.2013.02.051.
4 杨春, 张瑞. 抑郁障碍青少年自伤行为影响因素分析[J]. 中国学校卫生, 2021, 42(6): 879-882. DOI: 10.16835/j.cnki.1000-9817.2021.06.019.
5 Xia L, Yao S. The involvement of genes in adolescent depression: a systematic review[J]. Front Behav Neurosci, 2015, 9: 329. PMID: 26733829. PMCID: PMC4685064. DOI: 10.3389/fnbeh.2015.00329.
6 左文博, 李淑英, 吕培培, 等. 5-HTTLPR基因多态性与首发青少年重性抑郁障碍临床特征及认知功能的相关性[J]. 中华行为医学与脑科学杂志, 2016, 25(12): 1081-1086. DOI: 10.3760/cma.j.issn.1674-6554.2016.12.005.
7 田相娟. 5-HTTLPR基因、BDNF基因与母亲教养行为对青少年早期抑郁的影响[D]. 济南: 山东师范大学, 2017.
8 Palma-Gudiel H, Fa?anás L. An integrative review of methylation at the serotonin transporter gene and its dialogue with environmental risk factors, psychopathology and 5-HTTLPR[J]. Neurosci Biobehav Rev, 2017, 72: 190-209. PMID: 27880876. DOI: 10.1016/j.neubiorev.2016.11.011.
9 闵文蛟, 周波, 马敏, 等. 5-羟色胺转运蛋白基因多态性与抑郁症临床表型的关联性[J]. 中华行为医学与脑科学杂志, 2016, 25(9): 797-802. DOI: 10.3760/cma.j.issn.1674-6554.2016.09.006.
10 于跃, 刘祥, 杨振兴, 等. 5-羟色胺转运体基因多态性与青少年暴力犯罪行为的相关性研究[J]. 中华医学遗传学杂志, 2012, 29(4): 468-473. PMID: 22875509. DOI: 10.3760/cma.j.issn.1003-9406.2012.04.020.
11 Fratelli C, Siqueira J, Silva C, et al. 5HTTLPR genetic variant and major depressive disorder: a review[J]. Genes (Basel), 2020, 11(11): 1260. PMID: 33114535. PMCID: PMC7692865. DOI: 10.3390/genes11111260.
12 Culverhouse RC, Saccone NL, Horton AC, et al. Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression[J]. Mol Psychiatry, 2018, 23(1): 133-142. PMID: 28373689. PMCID: PMC5628077. DOI: 10.1038/mp.2017.44.
13 Sarmiento-Hernández EI, Ulloa-Flores RE, Camarena-Medellín B, et al. Association between 5-HTTLPR polymorphism, suicide attempt and comorbidity in Mexican adolescents with major depressive disorder[J]. Actas Esp Psiquiatr, 2019, 47(1): 1-6. PMID: 30724325.
14 Ran L, Ai M, Wang W, et al. Rare variants in SLC6A4 cause susceptibility to major depressive disorder with suicidal ideation in Han Chinese adolescents and young adults[J]. Gene, 2020, 726: 144147. PMID: 31629822. DOI: 10.1016/j.gene.2019.144147.
15 Norkeviciene A, Gocentiene R, Sestokaite A, et al. A systematic review of candidate genes for major depression[J]. Medicina (Kaunas), 2022, 58(2): 285. PMID: 35208605. PMCID: PMC8875554. DOI: 10.3390/medicina58020285.
16 Rocha TB, Hutz MH, Salatino-Oliveira A, et al. Gene-environment interaction in youth depression: replication of the 5-HTTLPR moderation in a diverse setting[J]. Am J Psychiatry, 2015, 172(10): 978-985. PMID: 26315979. DOI: 10.1176/appi.ajp.2015.14070896.
17 Bleys D, Luyten P, Soenens B, et al. Gene-environment interactions between stress and 5-HTTLPR in depression: a meta-analytic update[J]. J Affect Disord, 2018, 226: 339-345. PMID: 29031184. DOI: 10.1016/j.jad.2017.09.050.
18 Zwolińska W, Dmitrzak-W?glarz M, S?opień A. Biomarkers in child and adolescent depression[J]. Child Psychiatry Hum Dev, 2023, 54(1): 266-281. PMID: 34590201. DOI: 10.1007/s10578-021-01246-y.
19 van Dalfsen JH, Markus CR. The involvement of sleep in the relationship between the serotonin transporter gene-linked polymorphic region (5-HTTLPR) and depression: a systematic review[J]. J Affect Disord, 2019, 256: 205-212. PMID: 31181376. DOI: 10.1016/j.jad.2019.05.047.
20 Carniel BP, da Rocha NS. Brain-derived neurotrophic factor (BDNF) and inflammatory markers: perspectives for the management of depression[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2021, 108: 110151. PMID: 33096156. DOI: 10.1016/j.pnpbp.2020.110151.
21 Wang M, Tian X, Zhang W. Interactions between the combined genotypes of 5-HTTLPR and BDNF Val66Met polymorphisms and parenting on adolescent depressive symptoms: a three-year longitudinal study[J]. J Affect Disord, 2020, 265: 104-111. PMID: 32090731. DOI: 10.1016/j.jad.2020.01.064.
22 Terracciano A, Piras MG, Lobina M, et al. Genetics of serum BDNF: meta-analysis of the Val66Met and genome-wide association study[J]. World J Biol Psychiatry, 2013, 14(8): 583-589. PMID: 22047184. PMCID: PMC3288597. DOI: 10.3109/15622975.2011.616533.
23 Zhang C, Ran L, Ai M, et al. Targeted sequencing of the BDNF gene in young Chinese Han people with major depressive disorder[J]. Mol Genet Genomic Med, 2020, 8(10): e1484. PMID: 32869548. PMCID: PMC7549566. DOI: 10.1002/mgg3.1484.
24 Egan MF, Kojima M, Callicott JH, et al. The BDNF val66Met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function[J]. Cell, 2003, 112(2): 257-269. PMID: 12553913. DOI: 10.1016/s0092-8674(03)00035-7.
25 Youssef MM, Underwood MD, Huang YY, et al. Association of BDNF val66Met polymorphism and brain BDNF levels with major depression and suicide[J]. Int J Neuropsychopharmacol, 2018, 21(6): 528-538. PMID: 29432620. PMCID: PMC6007393. DOI: 10.1093/ijnp/pyy008.
26 Wheeler AL, Felsky D, Viviano JD, et al. BDNF-dependent effects on amygdala-cortical circuitry and depression risk in children and youth[J]. Cereb Cortex, 2018, 28(5): 1760-1770. PMID: 28387866. PMCID: PMC5907350. DOI: 10.1093/cercor/bhx086.
27 Jiang Y, Ming Q, Gao Y, et al. Effects of BDNF Val66Met polymorphisms on brain structures and behaviors in adolescents with conduct disorder[J]. Eur Child Adolesc Psychiatry, 2020, 29(4): 479-488. PMID: 31264106. DOI: 10.1007/s00787-019-01363-z.
28 Hilt LM, Sander LC, Nolen-Hoeksema S, et al. The BDNF Val66Met polymorphism predicts rumination and depression differently in young adolescent girls and their mothers[J]. Neurosci Lett, 2007, 429(1): 12-16. PMID: 17959306. DOI: 10.1016/j.neulet.2007.09.053.
29 Kishi T, Yoshimura R, Ikuta T, et al. Brain-derived neurotrophic factor and major depressive disorder: evidence from meta-analyses[J]. Front Psychiatry, 2017, 8: 308. PMID: 29387021. PMCID: PMC5776079. DOI: 10.3389/fpsyt.2017.00308.
30 Koss KJ, Cummings EM, Davies PT, et al. Harsh parenting and serotonin transporter and BDNF Val66Met polymorphisms as predictors of adolescent depressive symptoms[J]. J Clin Child Adolesc Psychol, 2018, 47(sup1): S205-S218. PMID: 27736236. PMCID: PMC5391309. DOI: 10.1080/15374416.2016.1220311.
31 Zhao M, Chen L, Yang J, et al. BDNF Val66Met polymorphism, life stress and depression: a meta-analysis of gene-environment interaction[J]. J Affect Disord, 2018, 227: 226-235. PMID: 29102837. DOI: 10.1016/j.jad.2017.10.024.
32 Na KS, Won E, Kang J, et al. Differential effect of COMT gene methylation on the prefrontal connectivity in subjects with depression versus healthy subjects[J]. Neuropharmacology, 2018, 137: 59-70. PMID: 29723539. DOI: 10.1016/j.neuropharm.2018.04.030.
33 陈玄玄, 刘寒, 严文佳, 等. 多巴胺D4受体和COMT基因多态性在精神分裂症患者攻击行为中的交互作用[J]. 中国健康心理学杂志, 2021, 29(12): 1769-1773. DOI: 10.13342/j.cnki.cjhp.2021.12.003.
34 Hygen BW, Belsky J, Stenseng F, et al. Child exposure to serious life events, COMT, and aggression: testing differential susceptibility theory[J]. Dev Psychol, 2015, 51(8): 1098-1104. PMID: 26053146. DOI: 10.1037/dev0000020.
35 Abraham E, Scott MA, Blair C. Catechol-O-methyltransferase Val158Met genotype and early-life family adversity interactively affect attention-deficit hyperactivity symptoms across childhood[J]. Front Genet, 2020, 11: 724. PMID: 32765586. PMCID: PMC7381281. DOI: 10.3389/fgene.2020.00724.
36 Cao Y, Chen G, Ji L, et al. Inhibitory control mediates the associations between parenting practices and depressive symptoms in adolescents: the moderating role of catechol-O-methyltransferase (COMT) gene[J]. J Youth Adolesc, 2021, 50(10): 2079-2095. PMID: 34259955. DOI: 10.1007/s10964-021-01466-4.
37 Kant T, Koyama E, Zai CC, et al. COMT Val/MET and psychopathic traits in children and adolescents: a systematic review and new evidence of a developmental trajectory toward psychopathy[J]. Int J Mol Sci, 2022, 23(3): 1782. PMID: 35163702. PMCID: PMC8836546. DOI: 10.3390/ijms23031782.
38 Zhao B, Fan Q, Liu J, et al. Identification of key modules and genes associated with major depressive disorder in adolescents[J]. Genes (Basel), 2022, 13(3): 464. PMID: 35328018. PMCID: PMC8949287. DOI: 10.3390/genes13030464.
39 Kohlhoff J, Cibralic S, Hawes DJ, et al. Oxytocin receptor gene (OXTR) polymorphisms and social, emotional and behavioral functioning in children and adolescents: a systematic narrative review[J]. Neurosci Biobehav Rev, 2022, 135: 104573. PMID: 35149102. DOI: 10.1016/j.neubiorev.2022.104573.
40 Zhang W, Cao Y, Wang M, et al. The dopamine D2 receptor polymorphism (DRD2 TaqIA) interacts with maternal parenting in predicting early adolescent depressive symptoms: evidence of differential susceptibility and age differences[J]. J Youth Adolesc, 2015, 44(7): 1428-1440. PMID: 25941120. DOI: 10.1007/s10964-015-0297-x.
41 曹衍淼, 王美萍, 曹丛, 等. DRD2基因TaqIA多态性与同伴侵害对青少年早期抑郁的交互作用[J]. 心理学报, 2017, 49(1): 28-39. DOI: 10.3724/SP.J.1041.2017.00028.