Endoscopy is a common tool for the diagnosis and treatment of gastrointestinal disorders in children. The presence of bubbles in the gastrointestinal tract is one of the important factors affecting the clarity of endoscopic visual field, and the application of defoamers can significantly reduce bubbles in the gastrointestinal tract, improve the quality of gastrointestinal preparation, and further increase disease detection rate. Various studies have been conducted on gastrointestinal preparation before endoscopy in children, but there still lacks a uniform protocol for the application of defoamers. This article summarizes the use of defoamers in children before digestive endoscopy and related research advances and points out that existing studies on defoamers have a small sample size and that there are still controversies over the selection and timing of administration, so as to provide a reference for in-depth research on defoamers in the future.
GAO Jie-Xia, LIU Hai-Feng.
Recent research on the application of defoamers in children undergoing digestive endoscopy[J]. Chinese Journal of Contemporary Pediatrics. 2023, 25(5): 541-545 https://doi.org/10.7499/j.issn.1008-8830.2301074
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参考文献
1 Feng SM, Zhao Y, Xu Q, et al. Development and characterization of a new dimethicone nanoemulsion and its application for electronic gastroscopy examination[J]. Int J Nanomedicine, 2020, 15: 5405-5416. PMID: 32801696. PMCID: PMC7401323. DOI: 10.2147/IJN.S251113. 2 中华医学会消化内镜学分会儿科协作组, 中国医师协会内镜医师分会儿科消化内镜专业委员会. 中国儿童消化内镜诊疗相关肠道准备快速指南(2020)[J]. 中华消化内镜杂志, 2021, 38(2): 85-97. DOI: 10.3760/cma.j.cn321463-20201214-00970. 3 雷曙光, 田翠翠, 罗永煌, 等. 西甲硅油与二甲硅油消泡性能对比研究[J]. 药物分析杂志, 2012, 32(2): 296-300. DOI: 10.16155/j.0254-1793.2012.02.004. 4 王小丽, 张广友, 张宁, 等. 564例儿童无痛胃镜结果分析及安全性评估[J]. 现代医学与健康研究电子杂志, 2019, 3(22): 105-108. 5 查健忠, 戴星. 445例儿童慢性胃炎临床及内镜分析[J]. 中国医师进修杂志, 2016, 39(z1): 48-50. DOI: 10.3760/cma.j.issn.1673-4904.2016.z1.018. 6 Chen HW, Hsu HC, Hsieh TY, et al. Pre-medication to improve esophagogastroduodenoscopic visibility: a meta-analysis and systemic review[J]. Hepatogastroenterology, 2014, 61(134): 1642-1648. PMID: 25436356. 7 欧阳红娟, 徐斌, 赵红梅, 等. 西甲硅油在儿童电子胃镜胃体胃底观察中的价值[J]. 中国医师杂志, 2017, 19(5): 757-758. DOI: 10.3760/cma.j.issn.1008-1372.2017.05.035. 8 吴婕, 王胜楠, 丁俊杰, 等. 儿童胃镜检查前不同时点口服或不口服西甲硅油胃镜视野清晰度的随机平行对照试验[J]. 中国循证儿科杂志, 2015, 10(4): 245-249. DOI: 10.3969/j.issn.1673-5501.2015.04.002. 9 Woo JG, Kim TO, Kim HJ, et al. Determination of the optimal time for premedication with pronase, dimethylpolysiloxane, and sodium bicarbonate for upper gastrointestinal endoscopy[J]. J Clin Gastroenterol, 2013, 47(5): 389-392. PMID: 23442831. DOI: 10.1097/MCG.0b013e3182758944. 10 温必盛, 杨维忠, 崔光锐, 等. 不同剂量西甲硅油对患者胃镜检查效果的影响[J]. 中国内镜杂志, 2019, 25(8): 53-57. DOI: 10.3969/j.issn.1007-1989.2019.08.011. 11 马娟, 曾志刚, 邓卫平, 等. 胃镜检查前口服不同剂量西甲硅油的临床价值比较[J]. 中国全科医学, 2018, 21(6): 707-711. DOI: 10.3969/j.issn.1007-9572.2018.00.010. 12 汪伟. 不同祛泡剂在胃镜检查前处置中应用效果比较[J]. 吉林医学, 2018, 39(8): 1494-1497. DOI: 10.3969/j.issn.1004-0412.2018.08.038. 13 王洋, 孙梅. 357例儿童结肠镜检查回顾性研究[J]. 中国实用儿科杂志, 2022, 37(1): 55-58. DOI: 10.19538/j.ek2022010612. 14 中国医师协会内镜医师分会消化内镜专业委员会, 中国抗癌协会肿瘤内镜学专业委员会. 中国消化内镜诊疗相关肠道准备指南(2019, 上海)[J]. 中华内科杂志, 2019, 58(7): 485-495. PMID: 31269564. DOI: 10.3760/cma.j.issn.0578-1426.2019.07.002. 15 Wu L, Cao Y, Liao C, et al. Systematic review and meta-analysis of randomized controlled trials of simethicone for gastrointestinal endoscopic visibility[J]. Scand J Gastroenterol, 2011, 46(2): 227-235. PMID: 20977386. DOI: 10.3109/00365521.2010.525714. 16 串俊兰, 吕晶. 西甲硅油应用于肠道准备的有效性及安全性的系统评价[J]. 实用医院临床杂志, 2015, 12(6): 144-147. DOI: 10.3969/j.issn.1672-6170.2015.06.053. 17 Zhang S, Zheng D, Wang J, et al. Simethicone improves bowel cleansing with low-volume polyethylene glycol: a multicenter randomized trial[J]. Endoscopy, 2018, 50(4): 412-422. PMID: 29132175. DOI: 10.1055/s-0043-121337. 18 王洋, 黎晓琴, 史思文, 等. 聚乙二醇联合西甲硅油对结肠镜检查患者Boston肠道准备量表评分及耐受度的影响[J]. 中国综合临床, 2021, 37(5): 411-415. DOI: 10.3760/cma.j.cn101721-20201117-00050. 19 纪晨光, 张伟娟, 马会会, 等. 不同时间点服用西甲硅油在结肠镜检查前肠道准备中的作用[J]. 中华消化内镜杂志, 2019, 36(2): 131-133. DOI: 10.3760/cma.j.issn.1007-5232.2019.02.010. 20 Wu ZW, Zhan SG, Yang MF, et al. Optimal timing of simethicone supplement for bowel preparation: a prospective randomized controlled trial[J]. Can J Gastroenterol Hepatol, 2021, 2021: 4032285. PMID: 34746040. PMCID: PMC8566047. DOI: 10.1155/2021/4032285. 21 Li DF, Luo MH, Du QQ, et al. Efficacy of low-dose versus high-dose simethicone with polyethylene glycol for bowel preparation: a prospective randomized controlled trial[J]. J Gastroenterol Hepatol, 2020, 35(9): 1488-1494. PMID: 32128877. DOI: 10.1111/jgh.15022. 22 杨孝孝, 戴夫, 彭琼, 等. 不同时间口服二甲硅油对结肠镜检查效果的影响[J]. 胃肠病学和肝病学杂志, 2018, 27(7): 756-759. DOI: 10.3969/j.issn.1006-5709.2018.07.009. 23 邱萍, 付云辉, 刘书娜. 术中按需喷洒与术前口服二甲硅油在肠镜检查中的作用研究[J]. 深圳中西医结合杂志, 2021, 31(20): 26-28. DOI:10.16458/j.cnki.1007-0893.2021.20.009. 24 Gu Z, Wang Y, Lin K, et al. Magnetically controlled capsule endoscopy in children: a single-center, retrospective cohort study[J]. J Pediatr Gastroenterol Nutr, 2019, 69(1): 13-17. PMID: 30747810. DOI: 10.1097/MPG.0000000000002292. 25 Geropoulos G, Aquilina J, Kakos C, et al. Magnetically controlled capsule endoscopy versus conventional gastroscopy: a systematic review and meta-analysis[J]. J Clin Gastroenterol, 2021, 55(7): 577-585. PMID: 33883514. DOI: 10.1097/MCG.0000000000001540. 26 Liao Z, Hou X, Lin-Hu EQ, et al. Accuracy of magnetically controlled capsule endoscopy, compared with conventional gastroscopy, in detection of gastric diseases[J]. Clin Gastroenterol Hepatol, 2016, 14(9): 1266-1273.e1. PMID: 27211503. DOI: 10.1016/j.cgh.2016.05.013. 27 国家消化系统疾病临床医学研究中心(上海), 国家消化内镜质控中心, 中华医学会消化内镜学分会胶囊内镜协作组, 等. 中国磁控胶囊胃镜临床应用指南(精简版, 2021年, 上海)[J]. 中华消化杂志, 2021, 41(9): 582-587. DOI: 10.3760/cma.j.cn311367-20210522-00296. 28 Chen X, Dai N, Deng Y, et al. Premedication with reformulated simethicone and sodium bicarbonate improves mucosal visibility during upper gastrointestinal endoscopy: a double-blind, multicenter, randomized controlled trial[J]. BMC Gastroenterol, 2021, 21(1): 124. PMID: 33736601. PMCID: PMC7977252. DOI: 10.1186/s12876-021-01623-w. 29 丁一村, 金磊, 徐小青, 等. 西甲硅油在磁控胶囊胃镜胃内检查术前准备中的应用探讨[J]. 中华消化内镜杂志, 2018, 35(2): 137-138. DOI: 10.3760/cma.j.issn.1007-5232.2018.02.013. 30 年媛媛, 孟宪梅, 陈洪锁, 等. 磁控胶囊内镜通过时间影响因素及胃排空延迟的最佳干预时间分析[J]. 中华消化内镜杂志, 2020, 37(10): 746-749. DOI:10.3760/cma.j.cn321463-20191010-00109. 31 程伟伟, 顾竹珺, 汪星, 等. 磁控胶囊内镜在儿童再发性腹痛中的诊断价值[J]. 中国内镜杂志, 2023, 29(1): 71-76. 32 Wang YC, Pan J, Jiang X, et al. Repetitive position change improves gastric cleanliness for magnetically controlled capsule gastroscopy[J]. Dig Dis Sci, 2019, 64(5): 1297-1304. PMID: 30560329. DOI: 10.1007/s10620-018-5415-7. 33 国家消化系统疾病临床医学研究中心(上海), 国家消化内镜质控中心, 中华医学会消化内镜学分会胶囊内镜协作组, 等. 中国小肠胶囊内镜临床应用指南(2021, 上海)[J]. 中华消化内镜杂志, 2021, 38(8): 589-614. DOI: 10.3760/cma.j.cn321463-20210507-00298. 34 Rondonotti E, Spada C, Adler S, et al. Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) technical review[J]. Endoscopy, 2018, 50(4): 423-446. PMID: 29539652. DOI: 10.1055/a-0576-0566. 35 蒋立学, 白杨, 邓涛, 等. 小肠胶囊内镜肠道准备的二甲硅油散推荐剂量: 一项多中心随机对照研究[J]. 第三军医大学学报, 2021, 43(4): 311-317. DOI: 10.16016/j.1000-5404.202009008. 36 钟艺华, 韩杨, 唐显军. 二甲硅油的不同配伍方案在胶囊内镜肠道准备中的随机对照研究[J]. 中国内镜杂志, 2021, 27(11): 25-30. DOI: 10.12235/E20210150. 37 Spada C, Riccioni ME, Familiari P, et al. Polyethylene glycol plus simethicone in small-bowel preparation for capsule endoscopy[J]. Dig Liver Dis, 2010, 42(5): 365-370. PMID: 19736051. DOI: 10.1016/j.dld.2009.07.017. 38 张志宏, 邱春华, 李良平. 比较西甲硅油不同使用方法在胶囊内镜肠道准备中的效果[J]. 中华消化内镜杂志, 2016, 33(7): 473-475. DOI: 10.3760/cma.j.issn.1007-5232.2016.07.012. 39 陈川铁, 杨伟昂, 曾锻, 等. 二甲硅油散在小肠胶囊内镜肠道准备中的服用时间及剂量研究[J]. 现代消化及介入诊疗, 2021, 26(12): 1538-1541. DOI: 10.3969/j.issn.1672-2159.2021.12.013.
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