血小板-白细胞聚集体及其在川崎病发病中的研究进展

高立超; 龚方戚

doi:10.7499/j.issn.1008-8830.2302066

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中国当代儿科杂志 ›› 2023, Vol. 25 ›› Issue (6) : 587-594. DOI: 10.7499/j.issn.1008-8830.2302066

川崎病专栏

血小板-白细胞聚集体及其在川崎病发病中的研究进展

高立超, 龚方戚

作者信息 +

Recent research on platelet-leukocyte aggregates and their role in the pathogenesis of Kawasaki disease

GAO Li-Chao, GONG Fang-Qi

Author information +

文章历史 +

摘要

活化的血小板会与单核细胞、中性粒细胞、树突状细胞和淋巴细胞等各类白细胞相互作用，触发细胞间信号转导，从而导致血栓形成和炎症介质的大量合成。已在多种血栓性疾病和炎症性疾病中发现血液中血小板-白细胞聚集体水平升高，该文综述了最新文献，探讨血小板-白细胞聚集体形成机制、作用、检测方法及其在川崎病发病中的相关作用，为川崎病发病机制的研究提供了新思路。

Abstract

Activated platelets may interact with various types of leukocytes such as monocytes, neutrophils, dendritic cells, and lymphocytes, trigger intercellular signal transduction, and thus lead to thrombosis and synthesis of massive inflammatory mediators. Elevated levels of circulating platelet-leukocyte aggregates have been found in patients with thrombotic or inflammatory diseases. This article reviews the latest research on the formation, function, and detection methods of platelet-leukocyte aggregates and their role in the onset of Kawasaki disease, so as to provide new ideas for studying the pathogenesis of Kawasaki disease.

导出引用

高立超, 龚方戚. 血小板-白细胞聚集体及其在川崎病发病中的研究进展[J]. 中国当代儿科杂志. 2023, 25(6): 587-594 https://doi.org/10.7499/j.issn.1008-8830.2302066

GAO Li-Chao, GONG Fang-Qi. Recent research on platelet-leukocyte aggregates and their role in the pathogenesis of Kawasaki disease[J]. Chinese Journal of Contemporary Pediatrics. 2023, 25(6): 587-594 https://doi.org/10.7499/j.issn.1008-8830.2302066

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