高海拔地区健康足月新生儿脑氧代谢及脑电活动差异的多中心临床研究方案

泽碧; 高瑾; 赵晓芬; 李杨方; 张铁松; 刘晓梅; 毛辉; 秦明彩; 张奕; 杨永礼; 和春叶; 赵燕; 杜琨; 刘玲; 周文浩; 中国高原新生儿医学联盟

doi:10.7499/j.issn.1008-8830.2310102

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中国当代儿科杂志 ›› 2024, Vol. 26 ›› Issue (4) : 403-409. DOI: 10.7499/j.issn.1008-8830.2310102

研究方案

高海拔地区健康足月新生儿脑氧代谢及脑电活动差异的多中心临床研究方案

泽碧¹, 高瑾², 赵晓芬², 李杨方², 张铁松³, 刘晓梅³, 毛辉⁴, 秦明彩⁵, 张奕⁶, 杨永礼⁷, 和春叶⁸, 赵燕⁹, 杜琨², 刘玲², 周文浩^1,10,中国高原新生儿医学联盟

作者信息 +

Cerebral oxygen metabolism and brain electrical activity of healthy full-term neonates in high-altitude areas: a multicenter clinical research protocol

ZE Bi¹, GAO Jin², ZHAO Xiao-Fen², LI Yang-Fang², ZHANG Tie-Song³, LIU Xiao-Mei³, MAO Hui⁴, QIN Ming-Cai⁵, ZHANG Yi⁶, YANG Yong-Li⁷, HE Chun-Ye⁸, ZHAO Yan⁹, DU Kun², LIU Lin², ZHOU Wen-Hao^1,10，Chinese High Altitude Neonatal Medicine Alliance CASE REPORT

Author information +

文章历史 +

摘要

高原环境对新生儿神经功能的影响仍需进一步证据积累。通过无创脑近红外光谱技术和振幅整合脑电图检测技术可提供脑氧饱和度及脑电活动数据。该研究通过对不同海拔梯度健康足月新生儿生后3 d内不同时间点进行多次近红外光谱技术、振幅整合脑电图监测，将测得的脑氧饱和度、脑电活动数据在不同海拔间进行比较，并建立相应的参考值范围。该研究包括6家中国高原新生儿医学联盟参与单位，根据所在地海拔分为4个海拔梯度，分别是800 m、1 900 m、2 400 m和3 500 m，每个海拔梯度预计样本量170人。该多中心前瞻性队列研究将为高原环境对新生儿早期脑功能及代谢的影响提供证据支持。

Abstract

Further evidence is needed to explore the impact of high-altitude environments on the neurologic function of neonates. Non-invasive techniques such as cerebral near-infrared spectroscopy and amplitude-integrated electroencephalography can provide data on cerebral oxygenation and brain electrical activity. This study will conduct multiple cerebral near-infrared spectroscopy and amplitude-integrated electroencephalography monitoring sessions at various time points within the first 3 days postpartum for healthy full-term neonates at different altitudes. The obtained data on cerebral oxygenation and brain electrical activity will be compared between different altitudes, and corresponding reference ranges will be established. The study involves 6 participating centers in the Chinese High Altitude Neonatal Medicine Alliance, with altitude gradients divided into 4 categories: 800 m, 1 900 m, 2 400 m, and 3 500 m, with an anticipated sample size of 170 neonates per altitude gradient. This multicenter prospective cohort study aims to provide evidence supporting the impact of high-altitude environments on early brain function and metabolism in neonates.

导出引用

泽碧, 高瑾, 赵晓芬, 李杨方, 张铁松, 刘晓梅, 毛辉, 秦明彩, 张奕, 杨永礼, 和春叶, 赵燕, 杜琨, 刘玲, 周文浩，中国高原新生儿医学联盟. 高海拔地区健康足月新生儿脑氧代谢及脑电活动差异的多中心临床研究方案[J]. 中国当代儿科杂志. 2024, 26(4): 403-409 https://doi.org/10.7499/j.issn.1008-8830.2310102

ZE Bi, GAO Jin, ZHAO Xiao-Fen, LI Yang-Fang, ZHANG Tie-Song, LIU Xiao-Mei, MAO Hui, QIN Ming-Cai, ZHANG Yi, YANG Yong-Li, HE Chun-Ye, ZHAO Yan, DU Kun, LIU Lin, ZHOU Wen-Hao，Chinese High Altitude Neon. Cerebral oxygen metabolism and brain electrical activity of healthy full-term neonates in high-altitude areas: a multicenter clinical research protocol[J]. Chinese Journal of Contemporary Pediatrics. 2024, 26(4): 403-409 https://doi.org/10.7499/j.issn.1008-8830.2310102

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