Abstract：Objective To investigate the relationship of cerebrospinal fluid and serum levels of soluble interleukin-2 receptor (SIL-2R), endothelial nitric oxide synthase (eNOS), and cluster of differentiation 93 (CD93) with the progression and prognosis of viral encephalitis (VE) in children. Methods Prospectively, 102 children with VE admitted from January 2021 to January 2024 were selected as the VE group. The patients were divided into a mild subgroup (64 patients) and a severe subgroup (38 patients) according to disease progression. The patients were also divided into a good prognosis subgroup (29 patients) and a poor prognosis subgroup (73 patients) according to prognosis. A control group of 102 children with central nervous system diseases who were examined and found not to have VE during the same period was selected. The factors contributing to the poor prognosis of children with VE and the predictive value of SIL-2R, eNOS, and CD93 in cerebrospinal fluid and serum for the poor prognosis of children with VE were evaluated. Results Cerebrospinal fluid and serum SIL-2R, eNOS, and CD93 levels were significantly increased in the VE group, severe subgroup, and poor prognosis subgroup (P<0.05). Multivariate logistic regression analysis showed that high SIL-2R, eNOS, and CD93 levels in cerebrospinal fluid and serum were risk factors for poor prognosis in children with VE (P<0.05). Receiver operating characteristic curve analysis showed that the combination of cerebrospinal fluid SIL-2R, eNOS, and CD93 was superior to these individual indicators in prediction of poor prognosis in children with VE (P<0.05). Similarly, the combination of serum SIL-2R, eNOS, and CD93 was superior to these individual indicators in prediction of poor prognosis in children with VE (P<0.05). Conclusions The cerebrospinal fluid and serum levels of SIL-2R, eNOS, and CD93 are significantly elevated in children with VE, and they are associated with VE progression and prognosis.
SONG Jie,WANG Yi-Lin,CHU Jia-Qi. Relationship of cerebrospinal fluid and serum levels of SIL-2R, eNOS, and CD93 with the progression and prognosis of viral encephalitis in children[J]. CJCP, 2024, 26(10): 1072-1077.
van Westrhenen A, Smidt LCA, Seute T, et al. Diagnostic markers for CNS lymphoma in blood and cerebrospinal fluid: a systematic review[J]. Br J Haematol, 2018, 182(3): 384-403. PMID: 29808930. PMCID: PMC6099264. DOI: 10.1111/bjh.15410.
An L, Shen Y, Chopp M, et al. Deficiency of endothelial nitric oxide synthase (eNOS) exacerbates brain damage and cognitive deficit in a mouse model of vascular dementia[J]. Aging Dis, 2021, 12(3): 732-746. PMID: 34094639. PMCID: PMC8139201. DOI: 10.14336/AD.2020.0523.
Naymagon L, Tremblay D, Troy K, et al. Soluble interleukin-2 receptor (sIL-2r) level is a limited test for the diagnosis of adult secondary hemophagocytic lymphohistiocytosis[J]. Eur J Haematol, 2020, 105(3): 255-261. PMID: 32353917. DOI: 10.1111/ejh.13433.
Yu H, Yu W, Zhu M, et al. Changes in NSE and S-100β during the perioperative period and effects on brain injury in infants with biliary atresia undergoing parent donor liver transplantation[J]. Exp Ther Med, 2021, 22(1): 724. PMID: 34007333. PMCID: PMC8120510. DOI: 10.3892/etm.2021.10156.
Lee M, Park HS, Choi MY, et al. Significance of soluble CD93 in type 2 diabetes as a biomarker for diabetic nephropathy: integrated results from human and rodent studies[J]. J Clin Med, 2020, 9(5): 1394. PMID: 32397261. PMCID: PMC7290306. DOI: 10.3390/jcm9051394.
Nativel B, Ramin-Mangata S, Mevizou R, et al. CD93 is a cell surface lectin receptor involved in the control of the inflammatory response stimulated by exogenous DNA[J]. Immunology, 2019, 158(2): 85-93. PMID: 31335975. PMCID: PMC6742780. DOI: 10.1111/imm.13100.
Qiao N, Zhang J, Zhang Y, et al. Crosstalk between CD93, C1q and GIPC in the regulation of pneumococcal meningitis inflammation[J]. Ann Clin Lab Sci, 2022, 52(4): 634-641. PMID: 36197773.
