儿童艰难梭菌感染的治疗进展

甘宇; 吴志鸿; 李前龙; 卢朝霞; 陈琳琳

doi:10.7499/j.issn.1008-8830.2405055

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中国当代儿科杂志 ›› 2024, Vol. 26 ›› Issue (9) : 995-1001. DOI: 10.7499/j.issn.1008-8830.2405055

综述

儿童艰难梭菌感染的治疗进展

甘宇¹, 吴志鸿¹, 李前龙², 卢朝霞³, 陈琳琳^1,2

作者信息 +

Advances in the treatment of Clostridium difficile infection in children

GAN Yu¹, WU Zhi-Hong¹, LI Qian-Long², LU Zhao-Xia³, CHEN Lin-Lin^1,2

Author information +

文章历史 +

摘要

儿童艰难梭菌感染（Clostridium difficile infection, CDI）是医院获得性胃肠道感染的主要原因。目前对儿童CDI的治疗主要是抗菌药物，然而部分儿童在抗生素治疗后出现复发，甚至首次复发的儿童使用抗生素治疗后仍有再复发可能，此时对治疗方案的选择需要慎重，粪菌移植治疗被证明可用于复发性CDI且安全性较高。该文就国内外儿童CDI发病机制、危险因素、诊断及治疗的最新研究进展作一综述，并对粪菌移植治疗作重点概述。

Abstract

Clostridium difficile infection (CDI) is a major cause of hospital-acquired gastrointestinal infections in children. Current treatment for pediatric CDI primarily involves antibiotics; however, some children experience recurrence after antibiotic treatment, and those with initial recurrence remain at risk for further recurrences following subsequent antibiotic therapy. In such cases, careful consideration of treatment options is necessary. Fecal microbiota transplantation has been shown to be effective for recurrent CDI and has a high safety profile. This article reviews the latest research on the pathogenesis, risk factors, diagnosis, and treatment of pediatric CDI domestically and internationally, with a particular focus on fecal microbiota transplantation therapy.

导出引用

甘宇, 吴志鸿, 李前龙, 卢朝霞, 陈琳琳. 儿童艰难梭菌感染的治疗进展[J]. 中国当代儿科杂志. 2024, 26(9): 995-1001 https://doi.org/10.7499/j.issn.1008-8830.2405055

GAN Yu, WU Zhi-Hong, LI Qian-Long, LU Zhao-Xia, CHEN Lin-Lin. Advances in the treatment of Clostridium difficile infection in children[J]. Chinese Journal of Contemporary Pediatrics. 2024, 26(9): 995-1001 https://doi.org/10.7499/j.issn.1008-8830.2405055

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