宏基因组二代测序诊断儿童造血干细胞移植后毛霉菌病3例

李越; 周小辉; 王晓东; 王春静; 曹科; 刘四喜

doi:10.7499/j.issn.1008-8830.2408034

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中国当代儿科杂志 ›› 2025, Vol. 27 ›› Issue (2) : 219-224. DOI: 10.7499/j.issn.1008-8830.2408034

临床经验

宏基因组二代测序诊断儿童造血干细胞移植后毛霉菌病3例

李越¹, 周小辉¹, 王晓东¹, 王春静¹, 曹科², 刘四喜¹

作者信息 +

Diagnosis of mucormycosis in three children following hematopoietic stem cell transplantation using metagenomic next-generation sequencing

LI Yue, ZHOU Xiao-Hui, WANG Xiao-Dong, WANG Chun-Jing, CAO Ke, LIU Si-Xi

Author information +

文章历史 +

摘要

该文报道3例儿童造血干细胞移植术后合并毛霉菌病的临床特点和诊治经过并对相关文献进行复习。3例患儿以胸痛为首发症状，均经宏基因组二代测序早期明确为毛霉菌感染，2例治疗后痊愈，1例因播散性感染死亡。宏基因组二代测序推动了毛霉菌病的早期诊断和治疗，降低病死率，联合手术治疗是改善预后的重要手段。

Abstract

This article reports the clinical characteristics and treatment processes of three cases of mucormycosis occurring after hematopoietic stem cell transplantation in children, along with a review of relevant literature. All three patients presented with chest pain as the initial symptom, and metagenomic next-generation sequencing (mNGS) confirmed the mucycete infection early in all cases. Two patients recovered after treatment, while one succumbed to disseminated infection. mNGS has facilitated early diagnosis and treatment, reducing mortality rates. Additionally, surgical intervention is an important strategy for improving the prognosis of this condition.

导出引用

李越, 周小辉, 王晓东, 王春静, 曹科, 刘四喜. 宏基因组二代测序诊断儿童造血干细胞移植后毛霉菌病3例[J]. 中国当代儿科杂志. 2025, 27(2): 219-224 https://doi.org/10.7499/j.issn.1008-8830.2408034

LI Yue, ZHOU Xiao-Hui, WANG Xiao-Dong, WANG Chun-Jing, CAO Ke, LIU Si-Xi. Diagnosis of mucormycosis in three children following hematopoietic stem cell transplantation using metagenomic next-generation sequencing[J]. Chinese Journal of Contemporary Pediatrics. 2025, 27(2): 219-224 https://doi.org/10.7499/j.issn.1008-8830.2408034

参考文献

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