中国地中海贫血祛铁治疗指南（2025年）

doi:10.7499/j.issn.1008-8830.2411001

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中国当代儿科杂志 ›› 2025, Vol. 27 ›› Issue (4) : 377-388. DOI: 10.7499/j.issn.1008-8830.2411001

标准·方案·指南

中国地中海贫血祛铁治疗指南（2025年）

中国妇幼保健协会地中海贫血防治专业委员会；中华医学会儿科学分会血液学组；全国地中海贫血防控协作网；《中国当代儿科杂志》编辑委员会

作者信息 +

Guidelines for iron chelation therapy in thalassemia in China (2025)

Committee of Thalassemia Prevention and Treatment, China Maternal and Child Health Association; Subspecialty Group of Hematology, Society of Pediatrics, Chinese Medical Association; China Thalassemia Prevention and Control Collaboration Network; Editorial Board of Chinese Journal

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摘要

铁过载是地中海贫血的主要并发症，临床表现为心力衰竭、肝硬化、糖尿病、生长发育迟缓、性发育延迟等，严重者导致死亡。规范的祛铁治疗才能保证患者长期和高质量生存。该指南对铁过载的检测方法、祛铁治疗的启动时机、输血依赖型地中海贫血和非输血依赖型地中海贫血祛铁治疗策略、特殊情况下的祛铁治疗策略等提出了推荐意见，为地中海贫血祛铁治疗提供参考。

Abstract

Iron overload is a major complication of thalassemia, clinically manifested as heart failure, liver cirrhosis, diabetes, growth and development retardation, and delayed sexual development, with severe cases leading to death. Standardized iron chelation therapy is essential to ensure long-term and high-quality survival for patients. This guideline provides recommendations on methods for detecting iron overload, the timing for initiating iron chelation therapy, treatment strategies for transfusion-dependent and non-transfusion-dependent thalassemia, and special circumstances regarding iron chelation therapy, serving as a reference for iron chelation treatment in thalassemia.

导出引用

中国妇幼保健协会地中海贫血防治专业委员会；中华医学会儿科学分会血液学组；全国地中海贫血防控协作网；《中国当代儿科杂志》编辑委员会. 中国地中海贫血祛铁治疗指南（2025年）[J]. 中国当代儿科杂志. 2025, 27(4): 377-388 https://doi.org/10.7499/j.issn.1008-8830.2411001

Committee of Thalassemia Prevention and Treatment, China Maternal and Child Health Association; Subspecialty Group of Hematology, Society of Pediatrics, Chinese Medical Association; China Thalassemia Prevention and Control Collaboration Network; Editorial Board of Chinese Journal. Guidelines for iron chelation therapy in thalassemia in China (2025)[J]. Chinese Journal of Contemporary Pediatrics. 2025, 27(4): 377-388 https://doi.org/10.7499/j.issn.1008-8830.2411001

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