cGAS-STING信号通路在儿童免疫介导炎症性疾病中的研究进展

魏新悦; 龚小娟; 冀红

doi:10.7499/j.issn.1008-8830.2412098

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中国当代儿科杂志 ›› 2025, Vol. 27 ›› Issue (7) : 881-887. DOI: 10.7499/j.issn.1008-8830.2412098

综述

cGAS-STING信号通路在儿童免疫介导炎症性疾病中的研究进展

魏新悦 ,
龚小娟 (综述) ,
冀红 (审校)

作者信息 +

Research progress on the cGAS-STING signaling pathway in immune-mediated inflammatory diseases in children

Author information +

文章历史 +

摘要

环鸟苷酸-腺苷酸合成酶（cyclic GMP-AMP synthase, cGAS）-干扰素基因刺激因子（stimulator of interferon gene, STING）信号通路是免疫系统的重要组成部分，其通过识别细胞质中异常双链DNA，促进Ⅰ型干扰素等炎症因子表达，保护机体免受病原体感染。儿童免疫系统发育未成熟或存在基因突变时，易出现免疫紊乱，增加自身免疫性疾病（autoimmune disease, AID）和自身炎症性疾病的发病风险。近年研究表明，cGAS-STING信号通路异常激活与儿童AID和自身炎症性疾病发生相关。该文对cGAS-STING信号通路在儿童AID及自身炎症性疾病中的研究进展进行综述，以期为临床诊疗提供新方向。

Abstract

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon gene (STING) signaling pathway is a crucial component of the immune system. It detects abnormal cytosolic double-stranded DNA and promotes the expression of type I interferons and other inflammatory factors, thereby protecting the body from pathogenic infections. In children, an immature immune system or genetic mutations can lead to immune dysregulation, increasing the risk of autoimmune diseases (AID) and autoinflammatory diseases. Recent studies have shown that aberrant activation of the cGAS-STING signaling pathway is associated with the development of AID and autoinflammatory diseases in children. This review summarizes the research progress on the cGAS-STING signaling pathway in childhood AID and autoinflammatory diseases, aiming to provide new directions for clinical diagnosis and treatment.

导出引用

魏新悦, 龚小娟, 冀红. cGAS-STING信号通路在儿童免疫介导炎症性疾病中的研究进展[J]. 中国当代儿科杂志. 2025, 27(7): 881-887 https://doi.org/10.7499/j.issn.1008-8830.2412098

Xin-Yue WEI, Xiao-Juan GONG, Hong JI. Research progress on the cGAS-STING signaling pathway in immune-mediated inflammatory diseases in children[J]. Chinese Journal of Contemporary Pediatrics. 2025, 27(7): 881-887 https://doi.org/10.7499/j.issn.1008-8830.2412098

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