目的　探讨重度肥胖对血液粘度产生的影响。方法　检测27例单纯性重度肥胖儿童和20例健康儿童的血液粘度的变化，并进行相关分析。结果　肥胖组儿童的低、中、高切变率下的全血粘度、血浆粘度、全血还原粘度、红细胞聚集指数（ARBC）红细胞变形指数（TK） 均明显高于对照组；血浆粘度与胆固醇、纤维蛋白原的增高呈显著正相关；高切变率下的全血粘度与血浆粘度、胆固醇及纤维蛋白原呈显著正相关；低切变率下的全血粘度与血浆粘度、纤维蛋白原呈显著正相关。结论　重度肥胖能够引起血液高凝状态，成为心、脑血管疾病发生的高危因素。

Objective To study the effect of severe obesity on blood viscosity. Methods Blood viscosity and its major determinants were checked in 27 children with severe obesity and in 20 normal children. Results Plasma and whole blood viscosity were significantly increased in the obese group. The increase in low shear blood viscosity and aggregation index of RBC suggested an increased erythrocyte aggregation which can be explained mainly in terms of the effects of increased fibrinogen concentration and plasma viscosity, and the increase in high shear blood viscosity and TK (Deformability Index of RBC) indicated a decreased erythrocyte deformability which was associated with the levels of fibrinogen, cholesterol and plasma viscosity. Conclusions Severe obesity can cause blood hypercoagulation leading to a risk factor of cardiovascular and cerebrovascular diseases.